🧫
Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-als-spor
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.897417Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['CASP1/CGAS/CRH'], 'diseases': ['ALS']} |
| model_system | human |
| summary | # Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts ## Background and Rationale Sporadic amyotrophic lateral sclerosis (ALS) accounts for approximately 90% of cases, yet the biologi |
| replication_status | single_study |
| methodology_notes | # Sporadic ALS Initiation Biology: Deep Phenotyping Protocol ## Phase 1: Cohort Recruitment and Baseline Characterization (Months 1-12) **Participant Selection and Stratification**: Recruit 500 at-ri |
| primary_outcome | Identification of molecular signature predictive of ALS development within 2-3 years, combining genetic risk scores, biofluid biomarkers, and neurophysiological changes with >80% predictive accuracy. |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.897423'} |
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