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C9orf72 Repeat Expansion in ALS

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-diseases-c9orf72-repeat-expansion-a
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slugdiseases-c9orf72-repeat-expansion-als
entity_typedisease
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Linked Artifacts (168)
mentions🔬What are the mechanisms underlying tdp-43 phase separation t60%
mentions🔬What are the mechanisms underlying rna binding protein dysre60%
mentions🔬CRISPR-based therapeutic approaches for neurodegenerative di60%
mentions🔬Analyze the spectrum of microglial activation states (DAM, h60%
mentions🔬CRISPR-based therapeutic approaches for neurodegenerative di60%
mentions🔬RNA binding protein dysregulation across ALS FTD AD60%
mentions🔬TDP-43 undergoes liquid-liquid phase separation that becomes60%
mentions🔬RNA binding protein dysregulation across ALS FTD and AD60%
related🧫s:** - Single-cell RNA-seq to measure editing efficiency acr60%
related🧫Metabolic Pathway-Targeted Therapy in ALS60%
related🧫ALS Progression Rate Heterogeneity — mechanism and biomarker60%
related🧫ALS Regional Onset and Spread: Network-Level Staging Model60%
related🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk60%
related🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri60%
related🧫Blood Biomarker vs Tau PET for Treatment Monitoring60%
related🧫Brainstem Circuit Modulation for PSP60%
related🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT60%
related🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study60%
related🧫Environmental Exposure Causal Attribution in ALS — Experimen60%
related🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio60%
related🧫Microbiome-Gut Barrier Signatures in ALS — Experiment Design60%
related🧫N-of-1 Clinical Trial Design for CBS/PSP60%
related🧫Pre-Symptomatic Tau Detection in MAPT Mutation Carriers60%
related🧫Pre-Symptomatic Detection and Intervention Timing in Genetic60%
related🧫Progranulin Replacement Therapy for FTD — Vector Development60%
related🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD60%
related🧫PSP and CBS Biomarker Validation Study60%
related🧫Sleep and Respiratory Network Interaction in ALS — Experimen60%
related🧫TDP-43 PET Ligand Development for FTD and ALS60%
related🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des60%
mentions🧫s:** - Single-cell RNA-seq to measure editing efficiency acr55%
mentions🧫Metabolic Pathway-Targeted Therapy in ALS55%
mentions🧫ALS Progression Rate Heterogeneity — mechanism and biomarker55%
mentions🧫ALS Regional Onset and Spread: Network-Level Staging Model55%
mentions🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk55%
mentions🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri55%
mentions🧫Blood Biomarker vs Tau PET for Treatment Monitoring55%
mentions🧫Brainstem Circuit Modulation for PSP55%
mentions🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT55%
mentions🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study55%
mentions🧫Environmental Exposure Causal Attribution in ALS — Experimen55%
mentions🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio55%
mentions🧫Microbiome-Gut Barrier Signatures in ALS — Experiment Design55%
mentions🧫N-of-1 Clinical Trial Design for CBS/PSP55%
mentions🧫Pre-Symptomatic Tau Detection in MAPT Mutation Carriers55%
mentions🧫Pre-Symptomatic Detection and Intervention Timing in Genetic55%
mentions🧫Progranulin Replacement Therapy for FTD — Vector Development55%
mentions🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD55%
mentions🧫PSP and CBS Biomarker Validation Study55%
mentions🧫Sleep and Respiratory Network Interaction in ALS — Experimen55%
mentions🧫TDP-43 PET Ligand Development for FTD and ALS55%
mentions🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des55%
mentions🧪Mitochondrial-Lysosomal Contact Site Engineering55%
mentions🧪Circadian-Synchronized Proteostasis Enhancement55%
mentions🧪Selective HDAC3 Inhibition with Cognitive Enhancement55%
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mentions🧪Chaperone-Mediated APOE4 Refolding Enhancement55%
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mentions🧪Optogenetic Microglial Deactivation via Engineered Inhibitor55%
mentions🧪Senescence-Induced Lipid Peroxidation Spreading55%
mentions🧪Circadian-Synchronized LRP1 Pathway Activation55%
mentions🧪SASP-Driven Aquaporin-4 Dysregulation55%
mentions🧪Circadian-Gated Maresin Biosynthesis Amplification55%
mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna55%
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mentions🧪Digital Twin-Guided Metabolic Reprogramming55%
mentions🧪Lysosomal Enzyme Trafficking Correction55%
mentions🧪Circadian Clock-Autophagy Synchronization55%
mentions🧪Senescence-Activated NAD+ Depletion Rescue55%
mentions🧪TET2-Mediated Demethylation Rejuvenation Therapy55%
mentions🧪Serine/Arginine-Rich Protein Kinase Modulation55%
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related🔬What are the mechanisms underlying tdp-43 phase separation t54%
related🔬What are the mechanisms underlying rna binding protein dysre54%
related🔬CRISPR-based therapeutic approaches for neurodegenerative di54%
related🔬Analyze the spectrum of microglial activation states (DAM, h54%
related🔬CRISPR-based therapeutic approaches for neurodegenerative di54%
related🔬RNA binding protein dysregulation across ALS FTD AD54%
related🔬TDP-43 undergoes liquid-liquid phase separation that becomes54%
related🔬RNA binding protein dysregulation across ALS FTD and AD54%
related🧫s:** - Single-cell RNA-seq to measure editing efficiency acr54%
related🧫Metabolic Pathway-Targeted Therapy in ALS54%
related🧫ALS Progression Rate Heterogeneity — mechanism and biomarker54%
related🧫ALS Regional Onset and Spread: Network-Level Staging Model54%
related🧫Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk54%
related🧫Anti-Tau Therapy Failure Mechanism in PSP — Why Clinical Tri54%
related🧫Blood Biomarker vs Tau PET for Treatment Monitoring54%
related🧫Brainstem Circuit Modulation for PSP54%
related🧫Mechanism: C9orf72 Hexanucleotide Repeat Expansion in ALS/FT54%
related🧫C9orf72 Phenotype Divergence: ALS vs FTD Mechanism Study54%
related🧫Environmental Exposure Causal Attribution in ALS — Experimen54%
related🧫FXTAS Phenotypic Penetrance: Why Only 40% of FMR1 Premutatio54%
related🧫Microbiome-Gut Barrier Signatures in ALS — Experiment Design54%
related🧫N-of-1 Clinical Trial Design for CBS/PSP54%
related🧫Pre-Symptomatic Tau Detection in MAPT Mutation Carriers54%
related🧫Pre-Symptomatic Detection and Intervention Timing in Genetic54%
related🧫Progranulin Replacement Therapy for FTD — Vector Development54%
related🧫Mechanism: Progranulin Loss and TDP-43 Pathology in FTD54%
related🧫PSP and CBS Biomarker Validation Study54%
related🧫Sleep and Respiratory Network Interaction in ALS — Experimen54%
related🧫TDP-43 PET Ligand Development for FTD and ALS54%
related🧫Viral and Post-Infectious Mechanisms in ALS — Experiment Des54%
mentions🧪APOE-Dependent Autophagy Restoration50%
mentions🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding50%
mentions🧪Glycine-Rich Domain Competitive Inhibition50%
mentions🧪Cross-Seeding Prevention Strategy50%
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related🔬What are the mechanisms underlying perivascular spaces and g50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬How does metabolic reprogramming (glucose metabolism shifts,50%
related🧪Lysosomal Membrane Repair Enhancement50%
related🧪Lysosomal Calcium Channel Modulation Therapy50%
related🧪Axonal RNA Transport Reconstitution50%
related🧪Lysosomal Positioning Dynamics Modulation50%
related🧪Heat Shock Protein 70 Disaggregase Amplification50%
related🧪Nucleolar Stress Response Normalization50%
related🧪Multi-Modal Stress Response Harmonization50%
related🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation50%
mentions📖Massachusetts General Hospital40%
mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa40%
mentions🔬What are the mechanisms underlying protein aggregation cross40%
mentions🔬How does metabolic reprogramming (glucose metabolism shifts,40%
related🔬What are the mechanisms underlying tdp-43 phase separation t38%
related🔬What are the mechanisms underlying astrocyte reactivity subt38%
related🔬What are the mechanisms underlying blood-brain barrier trans38%
related🔬What are the mechanisms underlying microglia-astrocyte cross38%
related🔬What are the mechanisms underlying apoe4 structural biology 38%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa38%
related🔬What are the mechanisms underlying digital biomarkers and ai38%
related🔬What are the mechanisms underlying senolytic therapy for age38%
related🔬What are the mechanisms underlying neuroinflammation resolut38%
related🔬What are the mechanisms underlying what are the mechanisms b38%
related🔬Investigate how lipid raft composition (cholesterol metaboli38%
related🔬What are the mechanisms underlying sleep disruption as cause38%
related🔬What are the mechanisms underlying rna binding protein dysre38%
related🔬What are the mechanisms underlying synaptic pruning by micro38%
related🔬What are the mechanisms underlying mitochondrial transfer be38%
related🔬What are the mechanisms underlying epigenetic clocks and bio38%
related🔬What are the mechanisms underlying perivascular spaces and g38%
related🔬Analyze circuit-level changes in neurodegeneration using All38%
related🔬Epigenetic reprogramming in aging neurons38%
related🔬Investigate prion-like spreading of tau pathology through co38%
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