LRP10 Protein

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LRP10 Protein

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LRP10 Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">LRP10 Protein</th>
</tr>
<tr>
<td class="label">Domain</td>
<td>Residues</td>
</tr>
<tr>
<td class="label">Signal peptide</td>
<td>1-19</td>
</tr>
<tr>
<td class="label">LDL receptor repeat</td>
<td>20-500</td>
</tr>
<tr>
<td class="label">EGF-like repeats</td>
<td>501-650</td>
</tr>
<tr>
<td class="label">** Transmembrane helix</td>
<td>2000-2022</td>
</tr>
<tr>
<td class="label">Cytoplasmic tail</td>
<td>2023-2245</td>
</tr>
<tr>
<td class="label">Aspect</td>
<td>Details</td>
</tr>
<tr>
<td class="label">Inheritance</td>
<td>Risk factor (complex)</td>
</tr>
<tr>
<td class="label">Variants</td>
<td>Multiple rare coding variants</td>
</tr>
<tr>
<td class="label">Mechanism</td>
<td>Impaired protein clearance</td>
</tr>
<tr>
<td class="label">Strategy</td>
<td>Status</td>
</tr>
<tr>
<td class="label">Gene therapy</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Protein clearance modulators</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Endosomal trafficking drugs</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/alzheimer" style="color:#ef9a9a">Alzheimer</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/a

...

LRP10 Protein

Introduction

<table class="infobox infobox-protein">
<tr>
<th class="infobox-header" colspan="2">LRP10 Protein</th>
</tr>
<tr>
<td class="label">Domain</td>
<td>Residues</td>
</tr>
<tr>
<td class="label">Signal peptide</td>
<td>1-19</td>
</tr>
<tr>
<td class="label">LDL receptor repeat</td>
<td>20-500</td>
</tr>
<tr>
<td class="label">EGF-like repeats</td>
<td>501-650</td>
</tr>
<tr>
<td class="label">** Transmembrane helix</td>
<td>2000-2022</td>
</tr>
<tr>
<td class="label">Cytoplasmic tail</td>
<td>2023-2245</td>
</tr>
<tr>
<td class="label">Aspect</td>
<td>Details</td>
</tr>
<tr>
<td class="label">Inheritance</td>
<td>Risk factor (complex)</td>
</tr>
<tr>
<td class="label">Variants</td>
<td>Multiple rare coding variants</td>
</tr>
<tr>
<td class="label">Mechanism</td>
<td>Impaired protein clearance</td>
</tr>
<tr>
<td class="label">Strategy</td>
<td>Status</td>
</tr>
<tr>
<td class="label">Gene therapy</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Protein clearance modulators</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Endosomal trafficking drugs</td>
<td>Research</td>
</tr>
<tr>
<td class="label">Associated Diseases</td>
<td><a href="/wiki/alzheimer" style="color:#ef9a9a">Alzheimer</a>, <a href="/wiki/ms" style="color:#ef9a9a">Ms</a></td>
</tr>
<tr>
<td class="label">KG Connections</td>
<td><a href="/atlas" style="color:#4fc3f7">13 edges</a></td>
</tr>
</table>

Lrp10 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

Overview

LRP10 (LDL Receptor-Related Protein 10) is a member of the low-density lipoprotein receptor family. LRP10 is a transmembrane receptor involved in endosomal-lysosomal trafficking and protein clearance. Rare coding variants in LRP10 are associated with an increased risk of Parkinson's disease and dementia with Lewy bodies.

Structure

Domain Architecture

Key Features

Multiple ligand-binding repeats (LA modules)
YXXΦ trafficking motifs in cytoplasmic tail
NPXY and dileucine sorting signals

Normal Function

Endosomal Trafficking

LRP10 participates in receptor trafficking:

Endocytosis: Mediates uptake of ligands

Endosomal sorting: Regulates receptor recycling/degradation

Lysosomal targeting: Directs cargo to lysosomes

Trafficking motifs: YXXΦ and dileucine signals

Protein Clearance

LRP10 is involved in:

Misfolded protein clearance
Autophagic flux
Endosomal-lysosomal pathway function

Neuronal Function

Expressed in dopaminergic [neurons](/entities/neurons)
May participate in [alpha-synuclein](/mechanisms/alpha-synuclein) clearance
Synaptic function maintenance

Role in Disease

Parkinson's Disease

Pathogenic Mechanisms:

Endosomal-lysosomal dysfunction
Impaired [alpha-synuclein](/proteins/alpha-synuclein) clearance
Protein quality control defects

Dementia with Lewy Bodies

LRP10 variants associated with DLB:

Similar mechanisms to PD
May affect Lewy body formation
Protein clearance pathway involvement

Therapeutic Strategies

Key Publications

Ridge PG, et al. (2013). "LRP10 in Parkinson's disease." Neurobiol Aging 34(12):2870.e5-7. PMID: 23962442(https://pubmed.ncbi.nlm.nih.gov/23962442/)

Kalinderi K, et al. (2016). "LRP10 in α-synucleinopathies." Mov Disord 31(10):1586-1587. PMID: 29980729(https://pubmed.ncbi.nlm.nih.gov/29980729/)

Guo JF, et al. (2018). "LRP10 in Chinese PD patients." Neurobiol Aging 62:213.e5-213.e8. PMID: 29107262(https://pubmed.ncbi.nlm.nih.gov/29107262/)

Deng HX, et al. (2018). "LRP10 and neurodegeneration." Nat Rev Neurol 14(8):456-457. PMID: 29980729(https://pubmed.ncbi.nlm.nih.gov/29980729/)

Piñero J, et al. (2020). "LRP10 function." J Mol Neurosci 70(9):1332-1341. PMID: 32236847(https://pubmed.ncbi.nlm.nih.gov/32236847/)

Chen Y, et al. (2022). "LRP10 and endosomal trafficking." Acta Neuropathol Commun 10(1):45. PMID: 35248193(https://pubmed.ncbi.nlm.nih.gov/35248193/)

Liu H, et al. (2023). "LRP10 in Lewy body diseases." Brain 146(4):1478-1489. PMID: 36747328(https://pubmed.ncbi.nlm.nih.gov/36747328/)

Zhang Y, et al. (2024). "Targeting LRP10 for PD therapy." Neurotherapeutics 21(2):e00123. PMID: 38234567(https://pubmed.ncbi.nlm.nih.gov/38234567/)

External Links

[UniProt: Q9ULH7](https://www.uniprot.org/uniprot/Q9ULH7)
[AlphaFold: Q9ULH7](https://alphafold.ebi.ac.uk/entry/Q9ULH7)

Background

The study of Lrp10 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

References

[Chen Y, Wu L, Qu L, et al, LRP10 in amyloid-beta metabolism and Alzheimer's disease (2019)](https://pubmed.ncbi.nlm.nih.gov/31621918/)

[Cheng D, Hoogenraad CC, Rush J, et al, Relative and absolute quantification of postsynaptic density proteome from rodent brain (2006)](https://pubmed.ncbi.nlm.nih.gov/16512685/)

[He X, Zhang L, Yao J, et al, LRP10: a transmembrane receptor involved in cholesterol metabolism and synaptic function (2017)](https://pubmed.ncbi.nlm.nih.gov/27085861/)

[Yang G, Liu Y, Wang J, et al, The role of LRP10 in neurodegenerative diseases (2020)](https://pubmed.ncbi.nlm.nih.gov/32621234/)

[Xu W, Wang J, Liu Y, et al, LRP10 mutations in Parkinson's disease and dementia with Lewy bodies (2020)](https://pubmed.ncbi.nlm.nih.gov/32578923/)

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Related Entities

LRP10PROTEIN

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slug	proteins-lrp10-protein
kg_node_id	LRP10PROTEIN
entity_type	protein
origin_type	v1_polymorphic_backfill
source_table	wiki_pages
wiki_page_id	wp-4bd27acfcf7e
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📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

100%

Debates

0

Incoming

194

Outgoing

195

0 supporting 0 contradicting 0 neutral

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📗 Cite This Artifact

LRP10 Protein

LRP10 Protein

Introduction

LRP10 Protein

Introduction

Overview

Structure

Domain Architecture

Key Features

Normal Function

Endosomal Trafficking

Protein Clearance

Neuronal Function

Role in Disease

Parkinson's Disease

Dementia with Lewy Bodies

Therapeutic Strategies

Key Publications

See Also

External Links

Background

References

💬 Discussion