🧫
Normal Aging to Alzheimer's Disease Transition Trigger — Identifying the Critical Switch Point
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-normal-a
🧫 Experiment Protocol
Validation
Metadata
| experiment_type | validation |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.906617Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['C1Q/C3/CD38'], 'diseases': ["Alzheimer's Disease"]} |
| model_system | human |
| summary | # Normal Aging to Alzheimer's Disease Transition Trigger — Identifying the Critical Switch Point ## Background and Rationale This longitudinal validation study investigates the critical transition poi |
| replication_status | single_study |
| methodology_notes | **Phase 1: Participant Recruitment and Baseline Assessment (Months 1-6)** • Recruit 2,000 cognitively normal participants aged 65-85 years through community health centers and memory clinics • Screen |
| primary_outcome | Identification of the temporal sequence and threshold values of biomarker changes that precede cognitive decline in individuals transitioning from normal aging to AD pathology over 5-year follow-up. |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.906622'} |
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