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C1QA Gene

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slug	genes-c1qa
entity_type	gene
kg_node_id	C1QA

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Linked Artifacts (367)

mentions🧪Complement C1q Mimetic Decoy Therapy90%

mentions🧪Complement C1q Subtype Switching90%

mentions🧪Complement-Mediated Synaptic Pruning Dysregulation90%

mentions🧪Complement C1QA Spatial Gradient in Cortical Layers90%

targets🧪Complement C1q Mimetic Decoy Therapy90%

targets🧪Complement C1q Subtype Switching90%

targets🧪Complement-Mediated Synaptic Pruning Dysregulation90%

targets🧪Complement C1QA Spatial Gradient in Cortical Layers90%

analysis_target🔬What are the mechanisms underlying 4r-tau strain-specific sp80%

analysis_target🔬What are the mechanisms underlying synaptic pruning by micro80%

analysis_target🔬What gene expression changes in the aging mouse brain predic80%

analysis_target🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas80%

mentions🧫C1q neutralization experiment80%

mentions🧫Sevoflurane-induced neurotoxicity (SIN) model in rats80%

mentions🧫Sevoflurane-induced neurotoxicity (SIN) rat model80%

mentions🧪Complement C1q Mimetic Decoy Therapy80%

mentions🧪Complement C1q Subtype Switching80%

related🧪Complement C1q Subtype Switching80%

related🧫C1q neutralization experiment72%

mentions🧪Complement-Mediated Synaptic Pruning Dysregulation70%

mentions🔬What are the mechanisms underlying 4r-tau strain-specific sp70%

mentions🔬What are the mechanisms underlying synaptic pruning by micro70%

mentions🧫s:** - Compare brain penetration in FcRn+/+ vs FcRn-/- mice 70%

mentions🧫Proposed experiment from debate on Synaptic pruning by micro70%

mentions🧫Experiment: Autoimmune Hypothesis Testing in AD70%

mentions🧪Complement C1QA Spatial Gradient in Cortical Layers70%

mentions🧫scRNA-seq analysis of human atherosclerotic plaques70%

mentions🧫Validation of hub genes in ox-LDL treated RAW264.7 macrophag70%

mentions🧫Gene expression validation in apoE-/- mice70%

mentions🧫ox-LDL treatment of RAW264.7 macrophages70%

mentions🧫Machine learning-based identification of C1Q hub genes70%

mentions🧫Validation of hub genes in apoE-/- atherosclerotic mice70%

mentions🧪SASP-Mediated Complement Cascade Amplification70%

see_also🧪Complement C1q Mimetic Decoy Therapy70%

see_also🧪Complement C1q Subtype Switching70%

see_also🧪Complement-Mediated Synaptic Pruning Dysregulation70%

see_also🧪Complement C1QA Spatial Gradient in Cortical Layers70%

mentions🔬What are the mechanisms underlying 4r-tau strain-specific sp63%

mentions🔬What are the mechanisms underlying synaptic pruning by micro63%

see_also📖Amyloid-Related Imaging Abnormalities (ARIA)60%

see_also📖C1QC60%

see_also📖C3AR1 Gene60%

see_also📖CCL20 Gene60%

see_also📖CD163 (Hemoglobin Scavenger Receptor)60%

see_also📖CD5560%

see_also📖SPP1 Gene60%

see_also📖Alzheimer Indonesia60%

see_also📖AIF1 Gene60%

see_also📖C1QB — Complement Component 1Q Beta60%

see_also📖CCL4 Gene60%

see_also📖CCR160%

see_also📖CYBB — Cytochrome b-245, Beta Polypeptide60%

see_also📖RAMP160%

see_also📖SLC40A1 Gene60%

see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%

see_also📖ITGAM Gene60%

see_also📖TMEM119 — Transmembrane Protein 11960%

see_also📖ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Member 460%

see_also📖C3 — Complement Component 360%

see_also📖EPHB4 Gene60%

see_also📖GNAL — Gαolf Subunit60%

see_also📖NLGN1 Gene60%

see_also📖NTN1 Gene - Netrin 160%

see_also📖syna60%

see_also📖Neuroligin-1 Protein60%

see_also📖CERS6 Gene60%

see_also📖Accelerating Medicines Partnership for Alzheimer's Dise60%

see_also📖slc17a7 Gene60%

see_also📖APBB160%

see_also📖c1r60%

see_also📖C1S Gene60%

see_also📖cst360%

see_also📖SIRPA Gene60%

see_also📖CLN3 Gene - Ceroid Lipofuscinosis, Neuronal 360%

see_also📖DRD1 Gene60%

mentions🔬What gene expression changes in the aging mouse brain predic50%

mentions🔬SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪Excitatory Neuron Vulnerability via SLC17A7 Downregulation50%

mentions🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro50%

mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%

mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%

mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%

mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%

mentions🧪Competitive APOE4 Domain Stabilization Peptides50%

mentions🧪Glymphatic System-Enhanced Antibody Clearance Reversal50%

mentions🧪SASP-Driven Aquaporin-4 Dysregulation50%

mentions🧪Metabolic Switch Targeting for A1→A2 Repolarization50%

mentions🧪Lysosomal Positioning Dynamics Modulation50%

mentions🧪LRP1-Dependent Tau Uptake Disruption50%

mentions🧪Trans-Synaptic Adhesion Molecule Modulation50%

mentions🧪Selective Acid Sphingomyelinase Modulation Therapy50%

mentions🧪TREM2-mediated microglial tau clearance enhancement50%

mentions🧪Age-Dependent Complement C4b Upregulation Drives Synaptic Vu50%

mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%

mentions🧪Excitatory Neuron Vulnerability via SLC17A7 Downregulation50%

mentions🧪CYP46A1 Overexpression Gene Therapy50%

mentions🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th50%

see_also📖Agitation in Alzheimer's Disease50%

see_also📖Alzheimer's Disease50%

see_also📖Alzheimer's Disease Genetic Variants50%

see_also📖Alzheimer's Disease vs Parkinson's Disease Compari50%

see_also📖APP Mutations in Alzheimer's Disease50%

see_also📖DLB, Parkinson's Disease, and Alzheimer's Disease:50%

see_also📖Early-Onset Alzheimer's Disease (EOAD)50%

see_also📖Investment Landscape: Alzheimer's Disease50%

see_also📖Preclinical Alzheimer's Disease50%

see_also📖Prodromal Alzheimer's Disease50%

see_also📖PSEN1 Mutations in Alzheimer's Disease50%

see_also📖PSEN2 Mutations in Alzheimer's Disease50%

see_also📖Sporadic vs Familial Alzheimer's Disease: Comprehensive50%

see_also📖TREM2 Variants in Alzheimer's Disease50%

see_also📖Cell-Free DNA Biomarkers in Neurodegeneration45%

see_also📖Exosomal Biomarkers in Neurodegeneration45%

see_also📖Exosomal miR-155 in Neurodegeneration45%

see_also📖IL-6 (Interleukin-6) in Neurodegeneration45%

see_also📖Liquid Biopsy in Neurodegeneration45%

see_also📖Metabolomic Biomarkers in Neurodegeneration45%

see_also📖Neuroimaging Biomarkers for Neurodegeneration45%

see_also📖Synaptic Biomarkers in Neurodegeneration45%

see_also📖BEACoN Study - Biomarker Exploration in Aging, Cognition and45%

see_also📖Olfactory Mucosa, Blood and Urine for Identification of Earl45%

see_also📖Swedish BioFINDER 2 Study: Biomarkers and Neurodegeneration 45%

see_also📖Beta-Propeller Protein-Associated Neurodegeneration (BPAN)45%

see_also📖China Neurodegeneration Epidemiology45%

see_also📖DALY Methodology — Neurodegeneration45%

see_also📖Disease Progression & Staging in Neurodegeneration45%

see_also📖Economic Burden — Neurodegeneration45%

see_also📖European Neurodegeneration Epidemiology45%

see_also📖Familial vs Sporadic Neurodegeneration Comparison45%

see_also📖Global Neurodegeneration Epidemiology45%

see_also📖India Neurodegeneration Epidemiology45%

see_also📖Japan Neurodegeneration Epidemiology45%

see_also📖Manganese-Related Neurodegeneration (Manganism)45%

see_also📖mitochondrial-dysfunction-neurodegeneration-comparison45%

see_also📖Mitochondrial Diseases and Neurodegeneration Comparison Matr45%

see_also📖Mitochondrial Membrane Protein-Associated Neurodegeneration 45%

see_also📖Neurodegeneration with Brain Iron Accumulation (NBIA)45%

see_also📖Potential Impact Measures — Neurodegeneration45%

see_also📖Pantothenate Kinase-Associated Neurodegeneration (PKAN)45%

see_also📖PLA2G6-Associated Neurodegeneration (PLAN)45%

see_also📖Sleep Disorders in Neurodegeneration45%

see_also📖US Neurodegeneration Epidemiology45%

see_also📖Extracellular Vesicle and Tunneling Nanotube-Mediated Spread45%

see_also📖acetylcholine-signaling-neurodegeneration45%

see_also📖Advanced Glycation End Products in Neurodegeneration45%

see_also📖Advanced In Vitro Models for Neurodegeneration — Organoids, 45%

see_also📖Amylin Signaling in Neurodegeneration45%

see_also📖Antibody Therapy in Neurodegeneration45%

see_also📖Antisense Oligonucleotide (ASO) Therapy in Neurodegeneration45%

see_also📖Autosis Pathway in Neurodegeneration45%

see_also📖Axon Guidance Pathways in Neurodegeneration45%

see_also📖Basal Ganglia Circuit Dysfunction in Neurodegeneration45%

see_also📖becn1-autophagy-initiation-neurodegeneration-causal-chain45%

see_also📖CaMKII Signaling Pathway in Neurodegeneration45%

see_also📖Carbonic Anhydrase Modulator Therapy in Neurodegeneration45%

see_also📖Cerebral Amyloid Angiopathy in Neurodegeneration45%

see_also📖Cerebral Amyloid Angiopathy Pathway in Neurodegeneration45%

see_also📖Cholinergic System Dysfunction in Neurodegeneration45%

see_also📖Chrononutrition and Time-Restricted Eating in Neurodegenerat45%

see_also📖Neural Circuits in Neurodegeneration45%

see_also📖Cognitive Reserve and Resilience in Neurodegeneration45%

see_also📖Computational Disease Models for Neurodegeneration45%

see_also📖Convergent Pathways in Neurodegeneration45%

see_also📖Copper Homeostasis in Neurodegeneration45%

see_also📖COVID-19 Neurodegeneration Mechanism45%

see_also📖Diffusion MRI (DTI) in Neurodegeneration45%

see_also📖Digital Phenotyping in Neurodegeneration45%

see_also📖Down Syndrome Neurodegeneration Pathway45%

see_also📖Dystrophic Neurites in Neurodegeneration45%

see_also📖Endocannabinoid System in Neurodegeneration45%

see_also📖Endosomal-Lysosomal Pathway in Neurodegeneration45%

see_also📖Endosomal Sorting Defects in Neurodegeneration45%

see_also📖Endothelin Signaling Pathway in Neurodegeneration45%

see_also📖epigenetics-neurodegeneration45%

see_also📖ESCRT-III Inhibition by Alpha-Synuclein in Neurodegeneration45%

see_also📖FA2H-Associated Neurodegeneration Pathway45%

see_also📖Farnesoid X Receptor (FXR) Signaling in Neurodegeneration45%

see_also📖Galectin-3 Mechanism in Neurodegeneration45%

see_also📖Gangliosides in Neurodegeneration45%

see_also📖GDF15/GDF11 Signaling in Neurodegeneration45%

see_also📖GDNF Signaling Pathway in Neurodegeneration45%

see_also📖Ghrelin Signaling Pathway in Neurodegeneration45%

see_also📖Glucocorticoid Signaling Pathway in Neurodegeneration45%

see_also📖Glycosylation in Neurodegeneration45%

see_also📖gp130/IL-6 Family Cytokine Signaling in Neurodegeneration45%

see_also📖Hippocampal Neurogenesis in Neurodegeneration45%

see_also📖Histone Modification Pathways in Neurodegeneration45%

see_also📖HMGB1 Signaling in Neurodegeneration45%

see_also📖Homocysteine Neurotoxicity and Neurodegeneration45%

see_also📖IGF-1 Signaling Pathway in Neurodegeneration45%

see_also📖IL-1 Signaling Pathway in Neurodegeneration45%

see_also📖Integrated Stress Response in Neurodegeneration45%

see_also📖interleukin-6-signaling-neurodegeneration45%

see_also📖Intrinsic Apoptosis Pathway in Neurodegeneration45%

see_also📖Ion Channel Dysfunction in Neurodegeneration: Cross-Disease 45%

see_also📖Kidney-Brain Neurodegeneration Axis45%

see_also📖Lipid Dysregulation in Neurodegeneration45%

see_also📖Lipid Metabolism Dysregulation in Neurodegeneration45%

see_also📖Lysosomal Calcium Dysregulation in Neurodegeneration45%

see_also📖Magnetic Resonance Spectroscopy in Neurodegeneration45%

see_also📖Metal Homeostasis Dysregulation in Neurodegeneration45%

see_also📖Metal Homeostasis in Neurodegeneration45%

see_also📖Microglial Priming Pathway in Neurodegeneration45%

see_also📖MicroRNA Dysfunction in Neurodegeneration45%

see_also📖Mineralocorticoid Receptor Signaling in Neurodegeneration45%

see_also📖Mitochondrial Dynamics Pathway in Neurodegeneration45%

see_also📖Mitochondrial Fusion in Neurodegeneration45%

see_also📖Molecular Chaperones in Neurodegeneration45%

see_also📖mTOR Signaling in Neurodegeneration45%

see_also📖mTOR Signaling Pathway in Neurodegeneration45%

see_also📖Neural Circuit Disruption in Neurodegeneration45%

see_also📖Neurexin/Neuroligin Synaptic Adhesion Modulator Therapy in N45%

see_also📖Neurofilament Light Chain (NfL) Mechanism in Neurodegenerati45%

see_also📖Neuronal Hyperexcitability in Neurodegeneration45%

see_also📖Neuropil Threads in Neurodegeneration45%

see_also📖Neurotensin Signaling in Neurodegeneration45%

see_also📖Neurovascular Unit Dysfunction in Neurodegeneration45%

see_also📖NF-kB Signaling Pathway in Neurodegeneration45%

see_also📖Nitric Oxide Signaling in Neurodegeneration45%

see_also📖Noradrenergic Signaling Pathway in Neurodegeneration45%

see_also📖Neuropeptide Y Signaling in Neurodegeneration45%

see_also📖NRF2 Signaling Pathway in Neurodegeneration45%

see_also📖Nuclear Pore Complex Dysfunction in Neurodegeneration45%

see_also📖Orexin Signaling in Neurodegeneration45%

see_also📖OSK Reprogramming and Yamanaka Factors in Neurodegeneration45%

see_also📖P-Body (Processing Body) Pathway in Neurodegeneration45%

see_also📖Paranodal Dysfunction in Neurodegeneration45%

see_also📖Paraptosis in Neurodegeneration45%

see_also📖Parthanatos in Neurodegeneration45%

see_also📖Pericyte Loss in Neurodegeneration45%

see_also📖Peripheral Immune-Brain Crosstalk in Neurodegeneration45%

see_also📖PKR Pathway in Neurodegeneration45%

see_also📖PPAR Signaling Pathway in Neurodegeneration45%

see_also📖Prion Diseases in Neurodegeneration45%

see_also📖Prion-Like Spread in Neurodegeneration45%

see_also📖Prion Protein Metabolism in Neurodegeneration45%

see_also📖Progesterone Signaling Pathway in Neurodegeneration45%

see_also📖Prognostic Biomarkers in Neurodegeneration45%

see_also📖Protein Aggregation Comparison in Neurodegeneration45%

see_also📖Protein Aggregation Seeds in Neurodegeneration45%

see_also📖Protein O-GlcNAcylation Pathway in Neurodegeneration45%

see_also📖Cortical Involvement and Neurodegeneration in Progressive Su45%

see_also📖Purinergic Signaling in Neurodegeneration45%

see_also📖Quantum Biology and Coherent Energy Transfer in Neurodegener45%

see_also📖R-Loop Stress in Neurodegeneration45%

see_also📖RAN Translation in Neurodegeneration45%

see_also📖Retinal Degeneration Pathway in Neurodegeneration45%

see_also📖Ribosome Dysfunction in Neurodegeneration45%

see_also📖RNA Splicing in Neurodegeneration45%

see_also📖RNA-Targeted Therapies in Neurodegeneration45%

see_also📖Ribonuclease κ and Circular RNAs: A New Mechanism of Aging a45%

see_also📖S100 Protein Signaling Pathway in Neurodegeneration45%

see_also📖Senescent Cell Clearance in Neurodegeneration45%

see_also📖Serotonergic Dysfunction in Neurodegeneration45%

see_also📖Sex Differences in Neurodegeneration45%

see_also📖Short Chain Fatty Acids in Neurodegeneration45%

see_also📖Sigma-1 Receptor Signaling in Neurodegeneration45%

see_also📖Sirtuin-Mitochondrial Biogenesis Axis in Neurodegeneration45%

see_also📖Sleep Dysfunction in Neurodegeneration45%

see_also📖SUMOylation in Neurodegeneration45%

see_also📖synaptic-vesicle-cycling-neurodegeneration45%

see_also📖Synthetic Lethality and PARP Inhibition in Neurodegeneration45%

see_also📖T-Cell Dysfunction in Neurodegeneration45%

see_also📖Tau Kinase Signaling Cascade in Alzheimer's Disease45%

see_also📖Tertiary Lymphoid Organs in Neurodegeneration45%

see_also📖Therapeutic Targets in Neurodegeneration45%

see_also📖Transdiagnostic Proteomic Changes in Neurodegeneration45%

see_also📖ubiquitin-proteasome-dysfunction-neurodegeneration45%

see_also📖Ubiquitin-Proteasome System Dysfunction in Neurodegeneration45%

see_also📖Vagus Nerve Pathway in Neurodegeneration45%

see_also📖VEGF Signaling and Cerebral Angiogenesis in Neurodegeneratio45%

see_also📖vip-vasoactive-intestinal-peptide-signaling-neurodegeneratio45%

see_also📖WNK1-Bilirubin Signaling in Neuroinflammation and Neurodegen45%

see_also📖Wnt/β-Catenin Signaling Pathway in Neurodegeneration45%

mentions🔬Analyze circuit-level changes in neurodegeneration using All40%

related🧪Netrin-1 Gradient Restoration40%

related🧪Aquaporin-4 Polarization Rescue40%

mentions🔬What gene expression changes in the aging mouse brain predic35%