Disease Rankings
Overview This page ranks neurodegenerative diseases by various criteria including research activity, clinical trial count, therapeutic development, and knowledge base coverage in NeuroWiki. [@geneprotein]
Rankings by Research Activity | Rank | Disease | Research Activity | Clinical Trials |
Rankings by Knowledge Base Coverage | Rank | Disease | Page Count | Content Depth |
Rankings by Therapeutic Development ...
Disease Rankings
Overview This page ranks neurodegenerative diseases by various criteria including research activity, clinical trial count, therapeutic development, and knowledge base coverage in NeuroWiki. [@geneprotein]
Rankings by Research Activity | Rank | Disease | Research Activity | Clinical Trials |ALS | High | 100+ |
Rankings by Knowledge Base Coverage | Rank | Disease | Page Count | Content Depth |FTD | 50+ | Detailed |
Rankings by Therapeutic Development | Rank | Disease | Approved Treatments | Pipeline Candidates |
Disease Categories
Tauopathies Diseases characterized by [tau protein](/proteins/tau) pathology:
[Alzheimer's Disease](/diseases/alzheimers-disease) — Most common cause of dementia
[Progressive Supranuclear Palsy](/diseases/progressive-supranuclear-palsy) — Tauopathy with vertical gaze palsy
[Corticobasal Degeneration](/diseases/corticobasal-degeneration) — Asymmetric cortical and basal ganglia syndrome
[Primary Age-Related Tauopathy](/diseases/primary-age-related-tauopathy) — Aging-associated tau pathology
Synucleinopathies Diseases characterized by [alpha-synuclein](/proteins/alpha-synuclein) pathology:
[Parkinson's Disease](/diseases/parkinsons-disease) — Movement disorder with Lewy bodies
[Lewy Body Dementia](/diseases/lewy-body-dementia) — Fluctuating cognition and visual hallucinations
[Multiple System Atrophy](/diseases/multiple-system-atrophy) — Autonomic failure with parkinsonism
TDP-43 Proteinopathies Diseases characterized by [TDP-43](/mechanisms/tdp-43-proteinopathy) pathology:
[ALS](/diseases/amyotrophic-lateral-sclerosis) — Motor neuron disease
[Frontotemporal Dementia](/diseases/frontotemporal-dementia) — Behavioral and language variants
Other Neurodegenerative Diseases
[Huntington's Disease](/diseases/huntingtons) — CAG repeat expansion disorder
[Vascular Dementia](/diseases/vascular-dementia) — Cognitive decline from cerebrovascular disease
Research Trends Alzheimer's Disease dominates research activity with over 200 active clinical trials and the largest therapeutic pipeline. The approval of [lecanemab](/entities/lecanemab) and [donanemab](/entities/donanemab) represents a milestone in disease-modifying therapy development.
Parkinson's Disease has the highest number of approved treatments (20+) but remains without disease-modifying therapies. Focus is on alpha-synuclein targeting and neuroprotection.
ALS has seen recent momentum with FDA approvals (AMX0035, tofersen) but remains critically undertreated. Genetic understanding ([C9orf72](/entities/c9orf72), SOD1, FUS) is driving targeted therapy development.
Coverage Gaps
Top Entries with Thin Coverage These ranked items have limited content and would benefit from expansion:
[Primary Age-Related Tauopathy](/diseases/primary-age-related-tauopathy) — 9,562 characters
[Progressive Supranuclear Palsy](/diseases/progressive-supranuclear-palsy) — 10,335 characters
[ALS](/diseases/amyotrophic-lateral-sclerosis) — 13,173 characters
[Lewy Body Dementia](/diseases/lewy-body-dementia) — 13,522 characters
External Links
[PubMed](https://pubmed.ncbi.nlm.nih.gov/)
[KEGG Pathways](https://www.genome.jp/kegg/pathway.html)
References
Unknown, Gene/Protein databases (n.d.)
See Also
[ACVR1 Gene](/wiki/genes-acvr1) — interacts_with
[Riluzole ALS Trials](/wiki/clinical-trials-riluzole-als) — interacts_with
[CBL Gene](/wiki/genes-cbl) — associated_with
[CDC42 Gene](/wiki/genes-cdc42) — interacts_with
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