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Home
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Wiki
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Disease: Disease Rankings
disease
618 words
KG: RANKINGS
2026-03-24
kind:disease
section:diseases
state:published
Contents
Disease Rankings
Disease Info
Associated Genes
PIK3CA
KG Connections
25
knowledge graph edges
Databases
OMIM
Orphanet
ClinicalTrials
PubMed
Knowledge Graph
Related Hypotheses (2)
TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR
Score: 0.45
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
Related Analyses (16)
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · failed
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
TREM2 agonism vs antagonism in DAM microglia
neurodegeneration · archived
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
Is disrupted sleep a cause or consequence of neurodegenerati
neurodegeneration · failed
Immune atlas neuroinflammation analysis in neurodegeneration
Neuroinflammation · archived
Cell type vulnerability in Alzheimer's Disease (SEA-AD data)
neurodegeneration · failed
Cell type vulnerability in Alzheimer's Disease (SEA-AD data
neurodegeneration · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
TREM2 Therapeutic Strategy Post-INVOKE-2
neurodegeneration · completed
GBA-Synuclein Loop Therapeutics for PD
neurodegeneration · completed
Gut-Brain Axis Therapeutics for AD
neurodegeneration · completed
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · completed
Show 11 more
Related Experiments (2)
GPR109A receptor validation using knockout macrophages
exploratory · proposed · Score: 0.92
MAPK pathway inhibition by QTJD through butyrate mechanism
exploratory · proposed · Score: 0.90
See Also (15)
MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: interacts_with
Packard Center for ALS Research
institution · KG edge: interacts_with
TRAF2 Gene
gene · KG edge: interacts_with
TGFBR1 — TGF-beta Receptor 1
gene · KG edge: interacts_with
RHOA Gene — Ras Homolog Family Member A
gene · KG edge: interacts_with
RAF1 — RAF1 Proto-Oncogene, Serine/Threonine Kinase (c-
gene · KG edge: interacts_with
RAC1 Gene
gene · KG edge: interacts_with
PTEN Gene
gene · KG edge: associated_with
PIK3CA Gene
gene · KG edge: associated_with
PI3K — Phosphoinositide 3-Kinase
gene · KG edge: interacts_with
MAPK1 Gene
gene · KG edge: associated_with
CDC42 Gene
gene · KG edge: interacts_with
CBL Gene
gene · KG edge: associated_with
ACVR1 Gene
gene · KG edge: interacts_with
Show 10 more
Knowledge Graph (12 edges)
RANKINGS
interacts_with
RAC1
RANKINGS
associated_with
MAPK1
RANKINGS
interacts_with
PI3K
RANKINGS
associated_with
CBL
RANKINGS
interacts_with
AKT
RANKINGS
interacts_with
RHOA
RANKINGS
interacts_with
TRAF2
RANKINGS
interacts_with
TRAF6
RANKINGS
interacts_with
TGFBR1
RANKINGS
associated_with
PTEN