Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuroinflammatory Cascade

**Background and Rationale** The gut-brain axis has emerged as a critical bidirectional communication pathway in neurodegeneration, with mounting evidence suggesting that intestinal dysfunction precedes and contributes to central nervous system pathology. Advanced glycation end-products (AGEs) represent a class of irreversibly modified proteins and lipids formed through non-enzymatic reactions between reducing sugars and amino groups. These compounds accumulate during aging and are elevated in ...