FGF2 — Fibroblast Growth Factor 2

FGF2 — Fibroblast Growth Factor 2

Pathway Diagram

```mermaid
flowchart TD
FGF2["FGF2<br/>Fibroblast Growth Factor 2"]
EGR1["EGR1<br/>Early Growth Response 1"]
ANGPT1["ANGPT1<br/>Angiopoietin 1"]
PDGFRB["PDGFRB<br/>Platelet Derived Growth<br/>Factor Receptor Beta"]
VEGFB["VEGFB<br/>Vascular Endothelial<br/>Growth Factor B"]
TLR4["TLR4<br/>Toll-like Receptor 4"]
HSPA1A["HSPA1A<br/>Heat Shock Protein<br/>Family A Member 1A"]

Angiogenesis["Angiogenesis<br/>Pathway"]
Fibroblast_Activation["Fibroblast<br/>Activation"]

ALS["ALS<br/>Amyotrophic Lateral<br/>Sclerosis"]
Alzheimer["Alzheimer's<br/>Disease"]
Neurodegeneration["Neurodegeneration"]
Neuroinflammation["Neuroinflammation"]
MS["Multiple<br/>Sclerosis"]

EGR1 -->|"regulates"| FGF2
FGF2 -->|"activates"| EGR1
FGF2 -->|"activates"| ANGPT1
FGF2 -->|"activates"| PDGFRB
FGF2 -->|"activates"| VEGFB
FGF2 -->|"regulates"| TLR4
FGF2 -->|"regulates"| HSPA1A

FGF2 -->|"promotes"| Angiogenesis
FGF2 -->|"causes"| Fibroblast_Activation

FGF2 -->|"biomarker_for"| ALS
FGF2 -->|"biomarker_for"| Alzheimer
FGF2 -->|"biomarker_for"| Neurodegeneration
FGF2 -->|"biomarker_for"| Neuroinflammation
FGF2 -->|"inhibits"| MS

ANGPT1 --> Angiogenesis
VEGFB --> Angiogenesis
TLR4 --> Neuroinflammation

style FGF2 fill:#006494
style EGR1 fill:#4a1a6b
style ANGPT1 fill:#4a1a6b
style PDGFRB fill:#4a1a6b
style VEGFB fill:#4a1a6b
style TLR4 fill:#4a1a6b
style HSPA1A fill:#1b5e

FGF2 — Fibroblast Growth Factor 2

Pathway Diagram

Overview

Fgf2 — Fibroblast Growth Factor 2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Introduction

Fgf2 — Fibroblast Growth Factor 2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. [@yang2020]

<div class="infobox infobox-gene"> [@fordperriss2001]
<table>
<tr><th colspan="2" style="background:#e8f4f8; text-align:center; font-size:1.1em;">Fibroblast Growth Factor 2</th></tr>
<tr><td><strong>Gene Symbol</strong></td><td>FGF2</td></tr>
<tr><td><strong>Full Name</strong></td><td>Fibroblast Growth Factor 2</td></tr>
<tr><td><strong>Chromosome</strong></td><td>4q28</td></tr>
<tr><td><strong>NCBI Gene ID</strong></td><td>[2246](https://www.ncbi.nlm.nih.gov/gene/2246)</td></tr>
<tr><td><strong>OMIM</strong></td><td>134760</td></tr>
<tr><td><strong>Ensembl ID</strong></td><td>ENSG00000108639</td></tr>
<tr><td><strong>UniProt ID</strong></td><td>[P09038](https://www.uniprot.org/uniprot/P09038)</td></tr>
<tr><td><strong>Associated Diseases</strong></td><td>Alzheimer's Disease, Parkinson's Disease, Stroke, Spinal Cord Injury</td></tr>
</table>
</div>

Function

FGF2 (basic FGF) encodes a member of the fibroblast growth factor family that binds to FGFR1-4 with varying affinities. FGF2 is a potent neurotrophic factor that promotes neuronal survival, proliferation, and differentiation. It plays critical roles in brain development, synaptic plasticity, and repair after injury. In the adult nervous system, FGF2 supports neurogenesis in the subventricular zone and [hippocampus](/brain-regions/hippocampus), promotes astrocyte reactivity after injury, and has neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and stroke. FGF2 also stimulates angiogenesis and glial proliferation, making it important for tissue repair.

Expression

FGF2 is expressed in:

• Brain (hippocampus, [cortex](/brain-regions/cortex), cerebellum)
• Spinal cord
• Retina
• Endothelial cells
• [Astrocytes](/entities/astrocytes) and [neurons](/entities/neurons)

Disease Associations

| Disease | Role | Mechanism |
|---------|------|-----------|
| Alzheimer's Disease | Risk/Progression | Various mechanisms depending on gene function |
| Parkinson's Disease | Risk/Progression | Various mechanisms depending on gene function |
| Amyotrophic Lateral Sclerosis | Risk/Progression | Various mechanisms depending on gene function |

Therapeutic Implications

Targeting FGF2 has therapeutic potential in neurodegenerative diseases through:

• Gene therapy approaches for loss-of-function variants
• Small molecule modulators of protein function
• Protein supplementation strategies

Key Publications

See Also

• [Autophagy](/mechanisms/autophagy)
• [Axonal Transport](/mechanisms/axonal-transport)
• [Amyotrophic Lateral Sclerosis](/diseases/amyotrophic-lateral-sclerosis)
• [Alzheimer's Disease](/diseases/alzheimers-disease)
• [Parkinson's Disease](/diseases/parkinsons-disease)

Overview

Fgf2 — Fibroblast Growth Factor 2 plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

Background

The study of Fgf2 — Fibroblast Growth Factor 2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.

Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.

External Links

• [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
• [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
• [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data

References

Pathway Diagram

The following diagram shows the key molecular relationships involving FGF2 — Fibroblast Growth Factor 2 discovered through SciDEX knowledge graph analysis: