Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflammatory Priming proposes targeting the Toll-like receptor 4 (TLR4) signaling axis as the critical bridge between intestinal barrier dysfunction and CNS neuroinflammation. Chronic low-grade endotoxemia — elevated circulating bacterial lipopolysaccharide (LPS) from a compromised gut barrier — primes microglia into a hyperresponsive state through repeated TLR4 activation, creating a "trained immunity" phenotype that amplifies neuroinflammat...