gene 530 words KG: FGF2 2026-03-21
kind:genesection:genesstate:published
Contents

FGF2 — Fibroblast Growth Factor 2

🧬 Gene Info
Gene SymbolFGF2
Full NameFibroblast Growth Factor 2
Chromosome4q28
FunctionFGF2 (basic FGF) encodes a member of the fibroblast growth factor family that binds to FGFR1-4 with varying affinities.
PathwaysAkt, Mapk, Pi3K, Pi3K/Akt
UniProt ID[P09038](https://www.uniprot.org/uniprot/P09038)
Ensembl IDENSG00000108639
OMIM134760
GeneCardsFGF2
Human Protein AtlasFGF2
Associated DiseasesALS, ANGIOGENESIS, Aging, CELL PROLIFERATION, Cancer, Carcinoma
InteractionsANGPT1, PDGFRB, VEGFB, BMP2, IL9, IL4
KG Connections490 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (21)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.48
Microbial Metabolite-Mediated α-Synuclein Disaggregation
Score: 0.45
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Pericyte Contractility Reset via Selective PDGFR-β Agonism
Score: 0.44

Related Analyses (10)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
APOE4 structural biology and therapeutic targeting strategie
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived

Related Experiments (5)

Irisin effects on angiogenesis in human endothelial cells
exploratory · proposed · Score: 0.90
Cytochrome Therapeutics
clinical · proposed · Score: 0.40
Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40
Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40
Multiscale Computational Modeling of Protein Aggregation Kin
validation · proposed · Score: 0.40

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: associated_with
Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
Wnt/β-Catenin Signaling Pathway in Neurodegeneration
mechanism · Pages share 3 hypotheses

Knowledge Graph (12 edges)

FGF2 activates ANGPT1
FGF2 activates PDGFRB
FGF2 activates VEGFB
FGF2 regulates CXCL10
FGF2 regulates HSPA1A
FGF2 regulates FGF8
FGF2 regulates TLR4
FGF2 regulates ISG15
FGF2 regulates STAT1
FGF2 regulates CSF2RA