Get4 Protein (Guided Entry Of Tail Anchored Protein 4) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Overview
Structure
GET4 is a component of the guided entry of tail-anchored proteins (GET) pathway, which facilitates the post-translational targeting of tail-anchored proteins to membranes. The GET4 protein acts as a co-chaperone that captures newly synthesized tail-anchored proteins and delivers them to the GET3 ATPase for membrane insertion.
The protein contains characteristic domains relevant to its function:
transmembrane domains for membrane localization
functional domains specific to its protein family
potential regulatory regions
Normal Function
Cellular Roles
Membrane protein targeting and insertion
Protein quality control mechanisms
Lipid metabolism and homeostasis
Cellular stress response pathways
Brain Expression
This protein is expressed in various brain regions:
Cerebral [cortex](/brain-regions/cortex) ([neurons](/entities/neurons) and glia)
[Hippocampus](/brain-regions/hippocampus)
Basal ganglia
[Cerebellum](/brain-regions/cerebellum)
Role in Disease
Alzheimer's Disease
Alzheimer's Disease is associated with altered GET4 function through genetic variants and expression changes.
Disease Mechanisms
Altered protein localization or trafficking
Impaired cellular quality control
Dysregulated lipid or ion homeostasis
Therapeutic Targeting
Current Approaches
Research is ongoing to develop therapeutic strategies:
The study of Get4 Protein (Guided Entry Of Tail Anchored Protein 4) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Three-Dimensional Structure
The crystal structures of GET4 in complex with GET3 have revealed:
A deep groove for tail-anchored protein binding
[Interface](/technologies/blackrock)residues for GET3 interaction
Conformational changes upon complex formation
The PDB structures 5YOJ and 6R1P show GET4 forms a homodimer, with each monomer consisting of: