🧫
Regulated Necrosis Validation Study in Parkinson's Disease
experiment
Created: 2026-04-02T17:01:41
By: crosslink-v2
Quality:
67%
✓ SciDEX
ID: experiment-exp-wiki-experiments-regulate
🧫 Experiment Protocol
Clinical
Metadata
| experiment_type | clinical |
| source | {'type': 'manual', 'source_name': 'wiki', 'extraction_date': '2026-04-16T01:00:16.904525Z', 'extracted_by': 'backfill_v1'} |
| entities | {'genes': ['ID'], 'diseases': ["Parkinson's Disease"]} |
| model_system | human |
| summary | # Regulated Necrosis Validation Study in Parkinson's Disease ## Background and Rationale This validation study investigates regulated necrosis pathways, including necroptosis, pyroptosis, and ferropto |
| replication_status | replicated |
| methodology_notes | **Phase 1: In Vitro Validation (Months 1-12)** • Establish primary dopaminergic neuronal cultures from human induced pluripotent stem cells (hiPSCs) from 50 PD patients and 25 healthy controls • Diff |
| primary_outcome | Demonstration of at least 2-fold increase in phospho-MLKL and cleaved gasdermin-D immunoreactivity in PD substantia nigra compared to controls, with dose-dependent neuroprotection (>50% cell survival) |
| extraction_metadata | {'extraction_confidence': 0.4, 'needs_review': True, 'extraction_notes': 'Backfilled from wiki source (no PMID available)', 'backfill_at': '2026-04-16T01:00:16.904533'} |
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