Neural Oscillation Dysfunction Validation in Parkinson's Disease

SUMMARY

# Neural Oscillation Dysfunction Validation in Parkinson's Disease ## Background and Rationale This validation study examines the Neural Oscillation Dysfunction Hypothesis in Parkinson's Disease, investigating whether abnormal brain oscillations represent core pathophysiological mechanisms that could serve as objective biomarkers for diagnosis, staging, and treatment monitoring. The hypothesis proposes that PD involves characteristic disruptions in neural oscillatory patterns, particularly exces

METHODOLOGY NOTES

**Phase 1: Participant Characterization and Baseline EEG (Weeks 1-6)** Recruit 80 participants: 40 PD patients (20 early stage I-II, 20 moderate stage III-IV) and 40 age-matched controls. Inclusion: clinically confirmed PD, stable dopaminergic medication ≥3 months, age 50-80. Exclusion: DBS implants, dementia (MoCA<24), psychiatric disorders, medications affecting EEG. Conduct comprehensive clinical assessment including UPDRS-III (ON/OFF states), Hoehn & Yahr staging, Montreal Cognitive Assessment, and detailed neuropsychological testing. Record high-density EEG (64-channel) during rest, simple motor tasks (finger tapping), and cognitive tasks (working memory, attention). **Phase 2: Advanced Neurophysiological Assessment (Weeks 7-10)** Perform simultaneous EEG-fMRI to examine neural oscillation-BOLD signal relationships. Record MEG for source localization of oscillatory activity in motor and cognitive networks. Conduct TMS-EEG to assess cortical reactivity and oscillatory responses