Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about abin1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ABIN1 |
| Full Name | TNFAIP3 Interacting Protein 1 |
| Chromosome | 5q33.1 |
| Function | encodes a ubiquitin-binding protein that serves as a critical negative regulator of nuclear factor kappa B (NF-κB) signaling. |
| Molecular Weight | 79 kDa |
| Amino Acids | 647 aa |
| Exons | 13 |
| Pathways | NF-κB, NF-κB signaling |
| UniProt ID | Q9Y5J7 |
| NCBI Gene ID | 10672 |
| Ensembl ID | ENSG00000134250 |
| OMIM | 607416 |
| GeneCards | ABIN1 |
| Human Protein Atlas | ABIN1 |
| Associated Diseases | Alzheimer's Disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["ABIN1"]
N1["PI3K"]
N0 -->|"regulates"| N1
N2["AKT"]
N0 -->|"regulates"| N2
N3["depression"]
N0 -->|"associated with"| N3
N4["Inflammation"]
N0 -->|"regulates"| N4
N5["INFLAMMATION"]
N0 -->|"regulates"| N5
N6["NF-KappaB"]
N0 -.->|"inhibits"| N6
N7["AUTOPHAGY"]
N0 -->|"regulates"| N7
N8["Autophagy"]
N0 -->|"regulates"| N8
N9["Nf-Kappab"]
N0 -.->|"inhibits"| N9
N10["TOLLIP"]
N10 -->|"regulates"| N0
N11["NFKB"]
N11 -.->|"inhibits"| N0
N12["UBIQUITIN"]
N12 -->|"regulates"| N0
N13["neurodegeneration"]
N0 -->|"implicated in"| N13
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 pathway
class N2 protein
class N3 disease
class N4 disease
class N5 gene
class N6 gene
class N7 gene
class N8 pathway
class N9 pathway
class N10 gene
class N11 gene
class N12 gene| Target | Relation | Type | Str |
|---|---|---|---|
| PI3K | regulates | pathway | 0.70 |
| AKT | regulates | protein | 0.70 |
| depression | associated_with | disease | 0.70 |
| Inflammation | regulates | disease | 0.65 |
| INFLAMMATION | regulates | gene | 0.60 |
| NF-ΚB | inhibits | gene | 0.60 |
| AUTOPHAGY | regulates | gene | 0.60 |
| Autophagy | regulates | pathway | 0.60 |
| Nf-Κb | inhibits | pathway | 0.60 |
| benchmark_ot_ad_answer_key:ABIN1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TOLLIP | regulates | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| NFKB | inhibits | gene | 0.60 |
| benchmark_ot_ad_answer_key:ABIN1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||