gene

abin1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about abin1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
10Outgoing
4Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolABIN1
Full NameTNFAIP3 Interacting Protein 1
Chromosome5q33.1
Functionencodes a ubiquitin-binding protein that serves as a critical negative regulator of nuclear factor kappa B (NF-κB) signaling.
Molecular Weight79 kDa
Amino Acids647 aa
Exons13
PathwaysNF-κB, NF-κB signaling
UniProt IDQ9Y5J7
NCBI Gene ID10672
Ensembl IDENSG00000134250
OMIM607416
GeneCardsABIN1
Human Protein AtlasABIN1
Associated DiseasesAlzheimer's Disease
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: abin1 — AlphaFold Q9Y5J7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

TNFAIP3 — TNF Alpha Induced Protein 3 (A20)

gene · 2414 words

ABIN1 (TNIP1) Gene

gene · 1970 words

ABIN1 Protein

protein · 1054 words

Genes Overview

gene · 905 words

Proteins

index · 296 words

Pathway Diagram

flowchart TD
    N0["ABIN1"]
    N1["PI3K"]
    N0 -->|"regulates"| N1
    N2["AKT"]
    N0 -->|"regulates"| N2
    N3["depression"]
    N0 -->|"associated with"| N3
    N4["Inflammation"]
    N0 -->|"regulates"| N4
    N5["INFLAMMATION"]
    N0 -->|"regulates"| N5
    N6["NF-KappaB"]
    N0 -.->|"inhibits"| N6
    N7["AUTOPHAGY"]
    N0 -->|"regulates"| N7
    N8["Autophagy"]
    N0 -->|"regulates"| N8
    N9["Nf-Kappab"]
    N0 -.->|"inhibits"| N9
    N10["TOLLIP"]
    N10 -->|"regulates"| N0
    N11["NFKB"]
    N11 -.->|"inhibits"| N0
    N12["UBIQUITIN"]
    N12 -->|"regulates"| N0
    N13["neurodegeneration"]
    N0 -->|"implicated in"| N13

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 pathway
    class N2 protein
    class N3 disease
    class N4 disease
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 pathway
    class N9 pathway
    class N10 gene
    class N11 gene
    class N12 gene

Outgoing (10)

TargetRelationTypeStr
PI3Kregulatespathway0.70
AKTregulatesprotein0.70
depressionassociated_withdisease0.70
Inflammationregulatesdisease0.65
INFLAMMATIONregulatesgene0.60

Incoming (4)

SourceRelationTypeStr
TOLLIPregulatesgene0.60
UBIQUITINregulatesgene0.60
NFKBinhibitsgene0.60
benchmark_ot_ad_answer_key:ABIN1data_indataset_row0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found