gene

ANK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

1Hypotheses

0Analyses

5Outgoing

1Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ANK2 (Ankyrin-B)
Full Name	Ankyrin-2
Chromosome	4q22-q25
Protein Family	Ankyrin repeat proteins
Protein Type	Adaptor Protein
Primary Expression	Heart (cardiac myocytes), brain (cortex, hippocampus, cerebellum), skeletal muscle, retina
Subcellular Localization	the sarcoplasmic reticulum and T-tubules
Amino Acids	300 aa
UniProt ID	Q01484
NCBI Gene ID	287
Ensembl ID	ENSG00000145362
OMIM	106410
N-terminal Domain	Contains 24 ankyrin repeats that mediate protein-protein interactions with membrane proteins
Spectrin-Binding Domain	The central region binds to β-spectrin, linking membrane proteins to the cytoskeleton
C-terminal Regulatory Domain	Contains death domain homology regions involved in signaling
Associated Diseases	Long QT Syndrome 4, Cardiac Hypertrophy, Autism Spectrum Disorder, Intellectual Disability, Neurodevelopmental Delay
Interactions	COMPLEMENT, IGF2BP1, PTEN
SciDEX Hypotheses	Neuronal-specific domain stabilization
KG Connections	6 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: ANK2 — AlphaFold Q01484 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    ANK2["ANK2"]
    Als{"Als"}
    ANK2 -->|"interacts with"| Als
    Autism{"Autism"}
    ANK2 -->|"interacts with"| Autism
    COMPLEMENT["COMPLEMENT"]
    ANK2 -->|"interacts with"| COMPLEMENT
    PTEN["PTEN"]
    ANK2 -->|"interacts with"| PTEN
    Complement(["Complement"])
    ANK2 -->|"interacts with"| Complement
    neurodegeneration["neurodegeneration"]
    ANK2 -->|"implicated in"| neurodegeneration
    IGF2BP1["IGF2BP1"]
    IGF2BP1 -->|"interacts with"| ANK2
    style ANK2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (5)

Target	Relation	Type	Str
Als	interacts_with	disease	0.65
Autism	interacts_with	disease	0.65
COMPLEMENT	interacts_with	gene	0.60
Complement	interacts_with	pathway	0.60
PTEN	interacts_with	gene	0.60

Incoming (1)

Source	Relation	Type	Str
IGF2BP1	interacts_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Neuronal-specific domain stabilization	0.550	neurodegeneration	-

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ANK2 in their description or question text

No additional research found

ANK2

Understanding Entity Pages

Wiki Pages (6)

Gene Page: ANK2 (Ankyrin-2)

PROSAP1 - Proline-Rich Synaptic-Associated Protein 1 (SHANK2)

PANK2 — Pantothenate Kinase 2

SHANK2 Gene

PANK2 Protein (Pantothenate Kinase 2)

SHANK2 Gene — SH3 and Multiple Ankyrin Repeat Domains 2