IGF2BP1

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF2BP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

IGF2BP1 (IMP1/CRD-BP) is an RNA-binding protein with six KH domains that regulates mRNA localization, stability, and translation in neurons. Implicated in ALS, PD, and AD through RNA metabolism and stress granule dynamics.

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graph TD
    IGF2BP1["IGF2BP1"]
    IGF2BP1 -->|"binds"| p38_MAPK["p38 MAPK"]
    IGF2BP1 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    IGF2BP1 -->|"target for"| Aging["Aging"]
    IGF2BP1 -->|"target for"| Ms["Ms"]
    IGF2BP1 -->|"target for"| Als["Als"]
    IGF2BP1 -->|"target for"| Cancer["Cancer"]
    IGF2BP1 -->|"activates"| Carcinoma["Carcinoma"]
    IGF2BP1 -->|"activates"| Tumor["Tumor"]
    ELAVL2["ELAVL2"] -->|"target for"| IGF2BP1
    C1Q["C1Q"] -->|"target for"| IGF2BP1
    MTOR["MTOR"] -->|"target for"| IGF2BP1
    CLPP["CLPP"] -->|"target for"| IGF2BP1
    RAB11["RAB11"] -->|"target for"| IGF2BP1
    STX17["STX17"] -->|"target for"| IGF2BP1
    RAB5["RAB5"] -->|"target for"| IGF2BP1
    SNAP29["SNAP29"] -->|"target for"| IGF2BP1
    HNRNPA2B1["HNRNPA2B1"] -->|"interacts"| IGF2BP1
    PI3K["PI3K"] -->|"target for"| IGF2BP1