gene 1,130 words KG: PANK2 2026-03-24
kind:genesection:genesstate:published
Contents

PANK2 — Pantothenate Kinase 2

🧬 Gene Info
Gene SymbolPANK2
Full NamePantothenate Kinase 2
Chromosome20p13
Protein TypeEnzyme
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionHigh in brain, especially basal ganglia
Subcellular Localizationthe mitochondrial matrix. It catalyzes the first and rate-limiting step in CoA biosynthesis, the phosphorylation of vita
Molecular Weight57 kDa
Amino Acids570 aa
UniProt IDQ9C0B0
NCBI Gene ID80025
Ensembl IDENSG00000125779
OMIM606157
GeneCardsPANK2
Human Protein AtlasPANK2
Associated DiseasesALS, Aging, Dystonia, Ms, Neurodegeneration
InteractionsPLA2G6, WDR45, ATP13A2, CP, DCAF17, FA2H
KG Connections41 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (3)

Bacterial Enzyme-Mediated Dopamine Precursor Synthesis
Score: 0.36
Senescence-Associated Myelin Lipid Remodeling
Score: 0.51
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (4)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Mitch A. Max
researcher · KG edge: therapeutic_target
Mitophagy Receptor Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
PLA2G6 — Phospholipase A2 Group VI
gene · KG edge: associated_with

Knowledge Graph (12 edges)

PANK2 associated_with PLA2G6
PANK2 therapeutic_target MAX
PANK2 therapeutic_target BID
PANK2 associated_with pantothenate kinase-associated neurodegeneration
PANK2 causes Pantothenate Kinase-Associated Neurodegeneration
PANK2 co_expressed_with PLA2G6
PANK2 co_expressed_with WDR45
PANK2 associated_with neurodegeneration
PANK2 interacts_with PLA2G6
PANK2 interacts_with WDR45