protein

ANXA1 PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ANXA1 PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

0Debates

Summary

Page for ANXA1 Protein — Annexin A1

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🔬 Protein Info

Gene Symbol	ANXA1
Full Name	Annexin A1
Chromosome	9q21.13
Target Class	Signaling Protein
Function	is an important component in the neurobiology of neurodegenerative diseases.
Mechanism of Action	Calcium-dependent phospholipid binding protein modulator
Primary Expression	the nervous system:
Druggability	Low (0.41)
Clinical Stage	Approved
Molecular Weight	37 kDa
Amino Acids	346 aa
Exons	13
GeneCards	ANXA1
Human Protein Atlas	ANXA1
Associated Diseases	aging, ALS, Alzheimer, cancer
Known Drugs/Compounds	aducanumab, GW201, Tat-Nts, Tat-NTS, Tat-NTS peptide
Interactions	AKT, AMPK, AND, APOPTOSIS, AUTOPHAGY, BECN1
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	Synaptic Phosphatidylserine Masking via Annexin A1
KG Connections	508 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    A["Gene expression"] --> B["ANXA1 PROTEIN"]
    B --> C["Protein folding and
quality control"]
    B --> D["Cellular signaling"]
    C --> E["Proteostasis"]
    D --> F["Neurotoxicity"]
    E --> G["Disease outcome"]
    F --> G
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class B protein
    class G disease

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ANXA1 PROTEIN in their description or question text

No additional research found