protein

ATAXIN-2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ATAXIN-2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

18Outgoing

3Incoming

0Experiments

0Debates

Summary

Protein profile: Ataxin-2

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🔬 Protein Info

Gene Symbol	ATAXIN
Protein Family	Ataxin-2 family, RNA-binding proteins
Function	is a cytoplasmic RNA-binding protein encoded by the ATXN2 gene that plays critical roles in RNA metabolism, stress granule dynamics, and translational control
Subcellular Localization	Cytoplasm, stress granules, RNA processing bodies (P-bodies)
Molecular Weight	140 kDa
Amino Acids	1313 aa
Pathways	Tdp-43
UniProt ID	Q99700
GeneCards	ATAXIN
Human Protein Atlas	ATAXIN
Interactions	TDP-43
KG Connections	21 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: ATAXIN-2 — AlphaFold Q99700 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

flowchart TD
    N0["ATAXIN-2"]
    N1["Tdp-43"]
    N0 -->|"inhibits"| N1
    N0 -->|"activates"| N1
    N2["disease"]
    N0 -->|"inhibits"| N2
    N0 -->|"associated with"| N1
    N3["CENTRAL NERVOUS SYSTEM"]
    N0 -->|"associated with"| N3
    N0 -->|"causes"| N1
    N4["amyotrophic lateral sclerosis"]
    N0 -->|"regulates"| N4
    N5["PARKINSON"]
    N0 -->|"regulates"| N5
    N6["Parkinson's Disease"]
    N0 -->|"regulates"| N6
    N7["Ataxia"]
    N0 -->|"regulates"| N7
    N8["Neuron"]
    N0 -->|"regulates"| N8
    N0 -->|"regulates"| N2
    N9["Spinocerebellar Ataxia"]
    N0 -->|"regulates"| N9
    N10["FTLD"]
    N0 -->|"regulates"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 pathway
    class N2 disease
    class N4 gene
    class N5 gene
    class N6 disease
    class N7 disease
    class N9 disease

Outgoing (18)

Target	Relation	Type	Str
TDP-43 mice	therapeutic_reduction_of_extends_lifespan_and_reduces_pathology	animal_model	0.90
TDP-43	interacts_with	protein	0.85
amyotrophic lateral sclerosis	regulates	gene	0.50
Tdp-43	activates	pathway	0.50
disease	inhibits	disease	0.50
Tdp-43	associated_with	pathway	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
Tdp-43	causes	pathway	0.50
PARKINSON	regulates	gene	0.50
Parkinson's Disease	regulates	disease	0.50
Tdp-43	inhibits	pathway	0.50
Neuron	regulates	cell_type	0.50
disease	regulates	disease	0.50
Spinocerebellar Ataxia	regulates	disease	0.50
FTLD	regulates	concept	0.50
PARKINSON'S	regulates	concept	0.50
MOTOR NEURON	regulates	concept	0.50
Ataxia	regulates	disease	0.50

Incoming (3)

Source	Relation	Type	Str
TARDBP	associated_with	gene	0.50
ATXN2	regulates	gene	0.50
PINK1	associated_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity