disease

Spinocerebellar Ataxia

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Spinocerebellar Ataxia: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

245Connections

0Hypotheses

0Analyses

38Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	MTOR, P62, DNA, TPP1, PPP3, SOD1, TREH, PARKINSON
KG Connections	234 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Spinocerebellar_Ataxia["Spinocerebellar Ataxia"] -->|"associated"| Tdp_43["Tdp-43"]
    style Tdp_43 fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    Spinocerebellar_Ataxia["Spinocerebellar Ataxia"] -->|"associated"| Sod1["Sod1"]
    style Sod1 fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    Spinocerebellar_Ataxia["Spinocerebellar Ataxia"] -->|"associated"| Mtor["Mtor"]
    style Mtor fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    Spinocerebellar_Ataxia["Spinocerebellar Ataxia"] -->|"associated"| Autophagy["Autophagy"]
    style Autophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#e0e0e0
    Spinocerebellar_Ataxia["Spinocerebellar Ataxia"] -->|"associated"| Spinal_Cord["Spinal Cord"]
    style Spinal_Cord fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    TREHALOSE["TREHALOSE"] -->|"activates"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
    style TREHALOSE fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    MTOR["MTOR"] -->|"associated"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
    style MTOR fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    P62["P62"] -->|"associated"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
    style P62 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    DNA["DNA"] -->|"associated"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
    style DNA fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    TPP1["TPP1"] -->|"associated"| Spinocerebellar_Ataxia["Spinocerebellar Ataxia"]
    style TPP1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style Spinocerebellar_Ataxia fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (45)

Target	Relation	Type	Str
Tdp-43	associated_with	pathway	0.55
Sod1	associated_with	pathway	0.55
Mtor	associated_with	pathway	0.55
Autophagy	associated_with	pathway	0.55
Mtor	expressed_in	pathway	0.55
Autophagy	regulates	pathway	0.55
Apoptosis	regulates	pathway	0.55
Mtor	regulates	pathway	0.55
Blood-Brain Barrier	inhibits	pathway	0.55
Tdp-43	expressed_in	pathway	0.55
Spinal Cord	associated_with	brain_region	0.50
Ca1	associated_with	brain_region	0.50
Ca3	associated_with	brain_region	0.50
White Matter	associated_with	brain_region	0.50
Brainstem	associated_with	brain_region	0.50
Cerebellum	associated_with	brain_region	0.50
Cortex	associated_with	brain_region	0.50
FRONTOTEMPORAL	activates	concept	0.50
DNA DAMAGE	activates	concept	0.50
MOTOR NEURON	activates	concept	0.50
Dna Damage Response	activates	pathway	0.50
HOMOLOGOUS RECOMBINATION	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
FRONTOTEMPORAL	expressed_in	concept	0.50
FIBROBLASTS	expressed_in	concept	0.50
CENTRAL NERVOUS SYSTEM	expressed_in	concept	0.50
ALZHEIMER'S	expressed_in	concept	0.50
PARKINSON'S	expressed_in	concept	0.50
HUNTINGTON'S	expressed_in	concept	0.50
STAU1	expressed_in	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
HUNTINGTON'S	associated_with	concept	0.50
Proteins	associated_with	protein	0.50
OLIGODENDROCYTES	associated_with	concept	0.50
FTLD	regulates	concept	0.50
PARKINSON'S	regulates	concept	0.50
MOTOR NEURON	regulates	concept	0.50

Incoming (200)

Source	Relation	Type	Str
TREHALOSE	activates	gene	0.65
MTOR	associated_with	gene	0.65
P62	associated_with	gene	0.65
DNA	associated_with	gene	0.65
TPP1	associated_with	gene	0.65
PPP3	associated_with	gene	0.65
SOD1	associated_with	gene	0.65
TREH	associated_with	gene	0.65
PARKINSON	associated_with	gene	0.65
STUB1	associated_with	gene	0.65
ATG	associated_with	gene	0.65
STIP1	associated_with	gene	0.65
SQSTM1	associated_with	gene	0.65
NEURODEGENERATIVE DISEASES	associated_with	gene	0.65
GAPDH	associated_with	gene	0.65
ALS	associated_with	gene	0.65
CTSB	associated_with	gene	0.65
PPP3CB	associated_with	gene	0.65
NEURODEGENERATION	activates	gene	0.65
ATG10	activates	gene	0.65
HUNTINGTON	associated_with	gene	0.65
GLA	associated_with	gene	0.65
LAMP1	associated_with	gene	0.65
HSPA8	associated_with	gene	0.65
TARDBP	associated_with	gene	0.65
MAP1LC3B	associated_with	gene	0.65
LGALS3	associated_with	gene	0.65
ATG12	activates	gene	0.65
BECN1	associated_with	gene	0.65
HSPB8	associated_with	gene	0.65
LAMP2A	associated_with	gene	0.65
TFEB	associated_with	gene	0.65
PPARGC1A	associated_with	gene	0.65
BAG3	associated_with	gene	0.65
MCOLN1	associated_with	gene	0.65
CALCINEURIN	activates	gene	0.65
BCL2	associated_with	gene	0.65
GENES	activates	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.65
AUTOPHAGY	associated_with	gene	0.65
SMN1	associated_with	gene	0.65
LC3	associated_with	gene	0.65
MTORC1	associated_with	gene	0.65
NEURODEGENERATIVE DISORDERS	regulates	gene	0.65
WIPI2	associated_with	gene	0.65
HTT	associated_with	gene	0.65
NEURON	associated_with	gene	0.65
ACTB	associated_with	gene	0.65
ULK1	associated_with	gene	0.65
SETX	associated_with	gene	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Spinocerebellar Ataxia

Understanding Entity Pages

Wiki Pages (20)

Cerebellar Function

Niemann-Pick Disease Type C (NPC)

ZDHHC13 — Zinc Finger DHHC-Type Containing 13

CREB Signaling in Neurodegeneration

Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)

Experiment Prioritization Index — Neurodegeneration

UBE2L3 — Ubiquitin-Conjugating Enzyme E2 L3

O-GlcNAcase (OGA) Inhibitor Landscape — Programs, Mechanisms, Companies

Deep Cerebellar Nuclear Neurons

Kyoto University

Climbing Fiber Inputs

Trinucleotide Repeat Expansion Disorders

Calcium Signaling Pathway in Neurodegeneration