protein

BCHEPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BCHEPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Butyrylcholinesterase (Buche) Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	BCHEPROTEIN
Aliases	Pseudocholinesterase, Serum cholinesterase, BuChE, BChE
Protein Family	Cholinesterase family, Serpentine superfamily
Protein Type	Enzyme
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	the brain, particularly in glial cells, where it plays important roles in cholinergic signaling and has been implicated in neurodegenerative diseases
Subcellular Localization	Plasma, Liver, Brain (astrocytes, microglia)
Molecular Weight	~68 kDa (tetrameric glycoprotein)
Amino Acids	574 amino acids
GeneCards	BCHEPROTEIN
Human Protein Atlas	BCHEPROTEIN
Gene [@buche2013] BCHE [@plasma2013] [@buche2016] UniProt	P06276
PDB Structures	1XUU, 2J4C, 4W2N
Length	574 amino acids
Associated Diseases	Alzheimer, Alzheimer'S Disease, Anxiety, Dementia, Depression
Known Drugs/Compounds	antidementia drugs
Interactions	BACE1, CHRFAM7A, CNTN1, ESR1, GABRB3, MAPT
KG Connections	156 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Butyrylcholinesterase (BuChE) Protein

protein · 1022 words

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Pathway Diagram

graph TD
    BCHEPROTEIN["BCHEPROTEIN"]
    neurodegeneration["neurodegeneration"]
    BCHEPROTEIN -->|"implicated_in"| neurodegeneration
    style BCHEPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity