Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BECLIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | BECLIN-1 |
| Chromosome | 17q21 |
| Protein Family | Atg6/Beclin family |
| Subcellular Localization | ER, mitochondria, trans-Golgi network, endosomes |
| Molecular Weight | ~52 kDa |
| Amino Acids | 450 |
| Exons | 12 |
| Pathways | PI3K |
| UniProt ID | Q14457 |
| GeneCards | BECLIN-1 |
| Human Protein Atlas | BECLIN-1 |
| Gene | BECN1 |
| Interactions | VPS34, SIRT-1, ATG5 |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
BECLIN_1["BECLIN-1"]
BECLIN_1 -->|"activates"| autophagy["autophagy"]
BECLIN_1 -->|"activates"| Autophagy["Autophagy"]
BECLIN_1 -->|"activates"| VPS34["VPS34"]
BECLIN_1 -->|"activates"| ST3GAL2["ST3GAL2"]
BECLIN_1 -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
BECLIN_1 -->|"references"| ULK1["ULK1"]
ginseng_root_extract["ginseng root extract"] -->|"contributes to"| BECLIN_1
AMPK["AMPK"] -->|"upstream_of"| BECLIN_1
autophagy -->|"regulates"| BECLIN_1
Autophagy -->|"interacts"| BECLIN_1
mTOR["mTOR"] -->|"activates"| BECLIN_1
ATG5["ATG5"] -->|"activates"| BECLIN_1Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||