protein

VPS34

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VPS34: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

181Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for VPS34 Protein

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🔬 Protein Info

Gene Symbol	VPS34
Function	Vps34 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Subcellular Localization	\| Endosome, Autophagosome ! Protein Family \| PI3K class III </div> ## Overview
Molecular Weight	100.7 kDa
Pathways	PI3K
GeneCards	VPS34
Human Protein Atlas	VPS34
Associated Diseases	Alzheimer
Known Drugs/Compounds	rapamycin
Interactions	WIPI2, IFNG, MAPK, KAT2B, PARKINSON, AMPK
KG Connections	180 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    VPS34["<b>VPS34</b>"]
    ULK1["ULK1"]
    ULK1 -->|"activates"| VPS34
    RUBCN["RUBCN"]
    RUBCN -->|"interacts with"| VPS34
    AUTOPHAGY["AUTOPHAGY"]
    VPS34 -->|"participates in"| AUTOPHAGY
    IFNG["IFNG"]
    VPS34 -->|"activates"| IFNG
    cancer["cancer"]
    VPS34 -->|"activates"| cancer
    MAPK["MAPK"]
    VPS34 -->|"activates"| MAPK
    OXIDATIVE_PHOSPHORYLATION["OXIDATIVE PHOSPHORYLATION"]
    VPS34 -->|"activates"| OXIDATIVE_PHOSPHORYLATION
    MTORC1["MTORC1"]
    VPS34 -->|"activates"| MTORC1
    Stem_Cell["Stem Cell"]
    VPS34 -->|"activates"| Stem_Cell
    Epithelial_Cell["Epithelial Cell"]
    VPS34 -->|"activates"| Epithelial_Cell
    disease["disease"]
    VPS34 -->|"activates"| disease
    Dendritic_Cell["Dendritic Cell"]
    VPS34 -->|"activates"| Dendritic_Cell
    CYP1A1["CYP1A1"]
    VPS34 -->|"activates"| CYP1A1
    DNA_DAMAGE["DNA DAMAGE"]
    VPS34 -->|"activates"| DNA_DAMAGE
    COLORECTAL_CANCER["COLORECTAL CANCER"]
    VPS34 -->|"activates"| COLORECTAL_CANCER
    Microrna["Microrna"]
    VPS34 -->|"activates"| Microrna
    Inflammatory_Bowel_Disease["Inflammatory Bowel Disease"]
    VPS34 -->|"activates"| Inflammatory_Bowel_Disease
    Reactive_Oxygen_Species["Reactive Oxygen Species"]
    VPS34 -->|"activates"| Reactive_Oxygen_Species
    RAPAMYCIN["RAPAMYCIN"]
    VPS34 -->|"activates"| RAPAMYCIN
    NUCLEUS["NUCLEUS"]
    VPS34 -->|"activates"| NUCLEUS
    ENDOPLASMIC_RETICULUM["ENDOPLASMIC RETICULUM"]
    VPS34 -->|"activates"| ENDOPLASMIC_RETICULUM
    PEROXISOME["PEROXISOME"]
    VPS34 -->|"activates"| PEROXISOME
    KAT2B["KAT2B"]
    VPS34 -->|"activates"| KAT2B
    TUMOR["TUMOR"]
    VPS34 -->|"activates"| TUMOR
    PARKINSON["PARKINSON"]
    VPS34 -->|"activates"| PARKINSON
    apoptosis["apoptosis"]
    VPS34 -->|"activates"| apoptosis
    AMPK["AMPK"]
    VPS34 -->|"activates"| AMPK
    MAP1LC3["MAP1LC3"]
    VPS34 -->|"activates"| MAP1LC3
    CELL_CYCLE["CELL CYCLE"]
    VPS34 -->|"activates"| CELL_CYCLE
    ACETYL_COA["ACETYL-COA"]
    VPS34 -->|"activates"| ACETYL_COA

Outgoing (53)

Target	Relation	Type	Str
AUTOPHAGY	participates_in	pathway	0.72
Alzheimer	associated_with	disease	0.60
MAPK signaling	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
WIPI2	activates	gene	0.60
Parkinson's disease	activates	disease	0.60
Wnt signaling	participates_in	pathway	0.60
apoptosis pathway	participates_in	pathway	0.60
epigenetic regulation	participates_in	pathway	0.60
traumatic brain injury	activates	disease	0.60
blood-brain barrier	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
unfolded protein response	participates_in	pathway	0.55
PI3K-AKT-mTOR signaling	participates_in	pathway	0.55
ubiquitin-proteasome	participates_in	pathway	0.55
autophagy pathway	participates_in	pathway	0.55
stem cells	expressed_in	cell_type	0.55
IFNG	activates	gene	0.50
cancer	activates	disease	0.50
MAPK	activates	gene	0.50
OXIDATIVE PHOSPHORYLATION	activates	pathway	0.50
MTORC1	activates	concept	0.50
Stem Cell	activates	cell_type	0.50
Epithelial Cell	activates	cell_type	0.50
disease	activates	disease	0.50
Dendritic Cell	activates	cell_type	0.50
CYP1A1	activates	concept	0.50
DNA DAMAGE	activates	concept	0.50
COLORECTAL CANCER	activates	disease	0.50
Microrna	activates	pathway	0.50
Inflammatory Bowel Disease	activates	disease	0.50
Reactive Oxygen Species	activates	process	0.50
RAPAMYCIN	activates	concept	0.50
NUCLEUS	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
PEROXISOME	activates	concept	0.50
KAT2B	activates	gene	0.50
TUMOR	activates	disease	0.50
PARKINSON	activates	gene	0.50
apoptosis	activates	process	0.50
AMPK	activates	protein	0.50
MAP1LC3	activates	gene	0.50
CELL CYCLE	activates	cell_type	0.50
ACETYL-COA	activates	concept	0.50
ACAT1	activates	concept	0.50
Chaperone	activates	pathway	0.50
Proteins	activates	protein	0.50
GSK3	activates	concept	0.50
CHAPERONE-MEDIATED AUTOPHAGY	activates	concept	0.50

Incoming (128)

Source	Relation	Type	Str
ULK1	activates	protein	0.90
RUBCN	interacts_with	protein	0.90
ATG5	activates	gene	0.70
CYP1A1	activates	gene	0.60
EGF	activates	gene	0.60
GCN2	activates	gene	0.60
IFN	activates	gene	0.60
IFNG	activates	gene	0.60
JNK	activates	gene	0.60
MAPK	activates	gene	0.60
MTOR	activates	gene	0.60
MTORC1	activates	gene	0.60
NLR	activates	gene	0.60
NRBF2	activates	gene	0.60
RB1	activates	gene	0.60
rapamycin	targets	drug	0.60
ACAT1	activates	gene	0.60
AMPK	activates	gene	0.60
ATG	activates	gene	0.60
CBP	activates	gene	0.60
GSK3	activates	gene	0.60
KAT2B	activates	gene	0.60
MAP1LC3	activates	gene	0.60
RUBCNL	activates	gene	0.60
USP13	activates	gene	0.60
DNA	activates	gene	0.60
ROS	activates	gene	0.60
ATG16L1	interacts_with	gene	0.60
ATG5	interacts_with	gene	0.60
PIK3C3	interacts_with	gene	0.60
RB1CC1	interacts_with	gene	0.60
BECN1	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
ATG14L	activates	gene	0.60
CAMK2	activates	gene	0.60
CASP3	activates	gene	0.60
DMPK	activates	gene	0.60
DMSO	activates	gene	0.60
GFAP	activates	gene	0.60
GFP	activates	gene	0.60
HIF	activates	gene	0.60
HIF1A	activates	gene	0.60
HMGCR	activates	gene	0.60
LAMP1	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
PLP1	activates	gene	0.60
PRKDC	activates	gene	0.60
SLC17A6	activates	gene	0.60
TRPM2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VPS34

Understanding Entity Pages

Summary

Wiki Pages (20)

Autophagy Mechanisms

Vesicle Trafficking Dysfunction in Corticobasal Syndrome

Gene-Mechanism-Therapy Causal Chains

Autophagy-Lysosomal Impairment Across Neurodegenerative Diseases

rapamycin-tauopathy

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

Chaperone-Mediated Autophagy in Neurodegeneration

ZFYVE26 Gene

Advanced Glycation End Products in Neurodegeneration

Autophagy Failure Comparison -- AD/PD/ALS/FTD/HD

ALS Pipeline

Autophagy-Lysosomal Pathway in Parkinson's Disease

autophagy-lysosome-dysfunction

Beclin-1 Protein

GLP-1 Signaling Pathway in Neurodegeneration

Lithium Continuation in ALS Trial

AMPK Signaling Pathway

MAP1LC3A Gene