HDAC1

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

HDAC1 is a protein involved in neurodegeneration research. Key relationships include: regulates, expressed in, activates. Associated with Aging, Alzheimer, Alzheimer's Disease. Connected to 111 entities in the SciDEX knowledge graph.

View on Wiki →

graph TD
    HDAC1["<b>HDAC1</b>"]
    p65["p65"]
    HDAC1 -->|"modifies"| p65
    Neurodegeneration{"Neurodegeneration"}
    HDAC1 -->|"contributes to"| Neurodegeneration
    Parkinson{"Parkinson"}
    HDAC1 -->|"regulates"| Parkinson
    Alzheimer{"Alzheimer"}
    HDAC1 -->|"regulates"| Alzheimer
    Neuroinflammation{"Neuroinflammation"}
    HDAC1 -->|"regulates"| Neuroinflammation
    Inflammation{"Inflammation"}
    HDAC1 -->|"regulates"| Inflammation
    Huntington{"Huntington"}
    HDAC1 -->|"regulates"| Huntington
    Ms{"Ms"}
    HDAC1 -->|"regulates"| Ms
    HDAC2["HDAC2"]
    HDAC1 -->|"associated with"| HDAC2
    HDAC3["HDAC3"]
    HDAC1 -->|"associated with"| HDAC3
    NEURODEGENERATION["NEURODEGENERATION"]
    HDAC1 -->|"associated with"| NEURODEGENERATION
    HDAC1 -->|"expressed in"| Ms
    GATA4["GATA4"]
    GATA4 -->|"interacts with"| HDAC1
    SIRT6["SIRT6"]
    SIRT6 -->|"regulates"| HDAC1
    HDAC11["HDAC11"]
    HDAC11 -->|"expressed in"| HDAC1
    HDAC2 -->|"expressed in"| HDAC1
    SIRT7["SIRT7"]
    SIRT7 -->|"regulates"| HDAC1
    SIRT5["SIRT5"]
    SIRT5 -->|"regulates"| HDAC1
    BDNF["BDNF"]
    BDNF -->|"regulates"| HDAC1
    SIRT1["SIRT1"]
    SIRT1 -->|"regulates"| HDAC1
    HDAC3 -->|"expressed in"| HDAC1
    HDAC7["HDAC7"]
    HDAC7 -->|"expressed in"| HDAC1
    SIRT4["SIRT4"]
    SIRT4 -->|"regulates"| HDAC1
    HDAC6["HDAC6"]
    HDAC6 -->|"expressed in"| HDAC1
    style HDAC1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0