concept

INTERLEUKIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERLEUKIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

663Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INTERLEUKIN

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interleukin-6 (IL-6)

entity · 957 words

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Pathway Diagram

graph TD
    INTERLEUKIN["INTERLEUKIN"]
    style INTERLEUKIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INTERLEUKIN -->|"regulates"| Fibrosis["Fibrosis"]
    INTERLEUKIN -->|"target for"| Als["Als"]
    INTERLEUKIN -->|"interacts"| Cancer["Cancer"]
    INTERLEUKIN -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    INTERLEUKIN -->|"target for"| Neuroinflammation["Neuroinflammation"]
    REL([REL]) -->|"regulates"| INTERLEUKIN
    IL_10([IL-10]) -->|"activates"| INTERLEUKIN
    CERS2([CERS2]) -->|"regulates"| INTERLEUKIN
    IGF1R([IGF1R]) -->|"regulates"| INTERLEUKIN
    DAG1([DAG1]) -->|"regulates"| INTERLEUKIN
    RNA([RNA]) -->|"regulates"| INTERLEUKIN
    ROS([ROS]) -->|"regulates"| INTERLEUKIN
    HSPG2([HSPG2]) -->|"regulates"| INTERLEUKIN
    RIPK1([RIPK1]) -->|"interacts"| INTERLEUKIN
    PPARG([PPARG]) -->|"interacts"| INTERLEUKIN

Outgoing (189)

Target	Relation	Type	Str
Spinal Cord Injury	activates	disease	0.60
Parkinson	expressed_in	disease	0.60
Depression	therapeutic_target	disease	0.60
Epilepsy	therapeutic_target	disease	0.60
Huntington	activates	disease	0.60
Pyroptosis	causes	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Diabetes	activates	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Atherosclerosis	associated_with	disease	0.60
Hypertension	associated_with	disease	0.60
Encephalitis	therapeutic_target	disease	0.60
Neurodegeneration	activates	disease	0.60
Neuroinflammation	expressed_in	disease	0.60
Cancer	regulates	disease	0.60
Alzheimer	activates	disease	0.60
Obesity	therapeutic_target	disease	0.60
Parkinson	activates	disease	0.60
Neuroinflammation	activates	disease	0.60
Aging	activates	disease	0.60
Multiple Sclerosis	associated_with	disease	0.60
Parkinson	associated_with	disease	0.60
Senescence	associated_with	disease	0.60
Aging	protects_against	disease	0.60
Senescence	protects_against	disease	0.60
Anxiety	associated_with	disease	0.60
Depression	associated_with	disease	0.60
Neuroinflammation	associated_with	disease	0.60
Neurodegeneration	inhibits	disease	0.60
Parkinson	regulates	disease	0.60
Multiple Sclerosis	interacts_with	disease	0.60
Als	inhibits	disease	0.60
Traumatic Brain Injury	inhibits	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Anxiety	activates	disease	0.60
Frontotemporal Dementia	activates	disease	0.60
Dementia	activates	disease	0.60
Amyotrophic Lateral Sclerosis	activates	disease	0.60
Lymphoma	activates	disease	0.60
Cancer	inhibits	disease	0.60
Neurodegeneration	associated_with	disease	0.60
Migraine	associated_with	disease	0.60
Ferroptosis	associated_with	disease	0.60
Diabetes	inhibits	disease	0.60
Atherosclerosis	inhibits	disease	0.60
Stroke	regulates	disease	0.60
Alzheimer	associated_with	disease	0.60
Aging	inhibits	disease	0.60
Pyroptosis	activates	disease	0.60
Als	associated_with	disease	0.60

Incoming (474)

Source	Relation	Type	Str
REL	regulates	gene	0.60
IL-10	activates	gene	0.60
CERS2	regulates	gene	0.60
IGF1R	regulates	gene	0.60
DAG1	regulates	gene	0.60
RNA	regulates	gene	0.60
ROS	regulates	gene	0.60
HSPG2	regulates	gene	0.60
STAR	expressed_in	gene	0.60
TCR	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
IL-18	expressed_in	gene	0.60
VIM	activates	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
PROGRANULIN	activates	gene	0.60
VIMENTIN	activates	gene	0.60
TGM2	activates	gene	0.60
PGRN	activates	gene	0.60
FGF21	activates	gene	0.60
CX3CL1	activates	gene	0.60
AMYLOID	activates	gene	0.60
HMGB1	activates	gene	0.60
PLAU	activates	gene	0.60
GHRL	activates	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
IGF-1	activates	gene	0.60
CXCL1	regulates	gene	0.60
IL-17	associated_with	gene	0.60
MMP9	regulates	gene	0.60
TNF	regulates	gene	0.60
JUN	regulates	gene	0.60
CXCL8	regulates	gene	0.60
TLR2	regulates	gene	0.60
P38	contributes_to	gene	0.60
DEMENTIA	causes	gene	0.60
TAU	causes	gene	0.60
ASTROCYTE	contributes_to	gene	0.60
AMYLOID	causes	gene	0.60
ASTROCYTES	contributes_to	gene	0.60
IL-1	causes	gene	0.60
PHAGOCYTOSIS	causes	gene	0.60
GLUT1	activates	gene	0.60
GBM	activates	gene	0.60
PERK	activates	gene	0.60
GLIOBLASTOMA	activates	gene	0.60
P2X7	activates	gene	0.60
ASTROCYTE	activates	gene	0.60
DEPRESSION	activates	gene	0.60
LDL	activates	gene	0.60
IDO1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERLEUKIN in their description or question text

No additional research found