concept

INTERLEUKIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERLEUKIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

663Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	INTERLEUKIN

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Interleukin-6 (IL-6)

entity · 957 words

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Pathway Diagram

graph TD
    INTERLEUKIN["INTERLEUKIN"]
    style INTERLEUKIN fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    INTERLEUKIN -->|"regulates"| Fibrosis["Fibrosis"]
    INTERLEUKIN -->|"target for"| Als["Als"]
    INTERLEUKIN -->|"interacts"| Cancer["Cancer"]
    INTERLEUKIN -->|"target for"| Multiple_Sclerosis["Multiple Sclerosis"]
    INTERLEUKIN -->|"target for"| Neuroinflammation["Neuroinflammation"]
    REL([REL]) -->|"regulates"| INTERLEUKIN
    IL_10([IL-10]) -->|"activates"| INTERLEUKIN
    CERS2([CERS2]) -->|"regulates"| INTERLEUKIN
    IGF1R([IGF1R]) -->|"regulates"| INTERLEUKIN
    DAG1([DAG1]) -->|"regulates"| INTERLEUKIN
    RNA([RNA]) -->|"regulates"| INTERLEUKIN
    ROS([ROS]) -->|"regulates"| INTERLEUKIN
    HSPG2([HSPG2]) -->|"regulates"| INTERLEUKIN
    RIPK1([RIPK1]) -->|"interacts"| INTERLEUKIN
    PPARG([PPARG]) -->|"interacts"| INTERLEUKIN

Outgoing (189)

Target	Relation	Type	Str
Encephalitis	activates	disease	0.60
Cancer	interacts_with	disease	0.60
Als	interacts_with	disease	0.60
Dementia	expressed_in	disease	0.60
Neurodegeneration	expressed_in	disease	0.60
Stroke	expressed_in	disease	0.60
Multiple Sclerosis	interacts_with	disease	0.60
Traumatic Brain Injury	inhibits	disease	0.60
Neuroinflammation	inhibits	disease	0.60
Fibrosis	interacts_with	disease	0.60
Encephalitis	inhibits	disease	0.60
Meningitis	inhibits	disease	0.60
Neuropathy	expressed_in	disease	0.60
Depression	associated_with	disease	0.60
Aging	therapeutic_target	disease	0.60
Ferroptosis	activates	disease	0.60
Spinal Cord Injury	activates	disease	0.60
Dementia	causes	disease	0.60
Depression	therapeutic_target	disease	0.60
Epilepsy	therapeutic_target	disease	0.60
Huntington	activates	disease	0.60
Neurodegeneration	causes	disease	0.60
Als	causes	disease	0.60
Neuroinflammation	causes	disease	0.60
Leukemia	inhibits	disease	0.60
Epilepsy	activates	disease	0.60
Cancer	activates	disease	0.60
Glioblastoma	activates	disease	0.60
Diabetes	associated_with	disease	0.60
Fibrosis	associated_with	disease	0.60
Obesity	associated_with	disease	0.60
Senescence	activates	disease	0.60
Depression	activates	disease	0.60
Atherosclerosis	activates	disease	0.60
Aging	associated_with	disease	0.60
Hypertension	associated_with	disease	0.60
Als	associated_with	disease	0.60
Atherosclerosis	associated_with	disease	0.60
Senescence	associated_with	disease	0.60
Aging	protects_against	disease	0.60
Senescence	protects_against	disease	0.60
Alzheimer	therapeutic_target	disease	0.60
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.60
Encephalitis	therapeutic_target	disease	0.60
Neuroinflammation	biomarker_for	disease	0.60
Alzheimer	expressed_in	disease	0.60
Atherosclerosis	expressed_in	disease	0.60
Pyroptosis	biomarker_for	disease	0.60
Necroptosis	biomarker_for	disease	0.60
Ferroptosis	biomarker_for	disease	0.60

Incoming (474)

Source	Relation	Type	Str
EGR2	activates	gene	0.60
SIRT6	inhibits	gene	0.60
NAD	inhibits	gene	0.60
CD38	activates	gene	0.60
NAMPT	inhibits	gene	0.60
STAR	expressed_in	gene	0.60
TCR	expressed_in	gene	0.60
CD8	expressed_in	gene	0.60
IL-18	expressed_in	gene	0.60
HEDGEHOG	activates	gene	0.60
HIPPO	activates	gene	0.60
EGFR	activates	gene	0.60
CYTOKINES	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
ITGA2B	activates	gene	0.60
IL-6	activates	gene	0.60
MYELIN	expressed_in	gene	0.60
VEGF	expressed_in	gene	0.60
AKT	activates	gene	0.60
P38	activates	gene	0.60
PRDX1	activates	gene	0.60
ERK1/2	activates	gene	0.60
CYTOKINES	regulates	gene	0.60
IL-6	transports	gene	0.60
MMP1	activates	gene	0.60
GPX4	activates	gene	0.60
P53	activates	gene	0.60
FERROPTOSIS	activates	gene	0.60
SLC7A11	activates	gene	0.60
SOX9	activates	gene	0.60
ROS	activates	gene	0.60
MMP3	activates	gene	0.60
PIEZO1	regulates	gene	0.60
PIEZO	regulates	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
PI3K	activates	gene	0.60
TNF	inhibits	gene	0.60
ROS	inhibits	gene	0.60
DRP1	inhibits	gene	0.60
OPA1	inhibits	gene	0.60
CATALASE	degrades	gene	0.60
INOS	activates	gene	0.60
IL-10	degrades	gene	0.60
CAT	degrades	gene	0.60
BDNF	degrades	gene	0.60
APOPTOSIS	degrades	gene	0.60
TNF	degrades	gene	0.60
ROS	degrades	gene	0.60
PARP1	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERLEUKIN in their description or question text

No additional research found