protein

BECLIN-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BECLIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

17Connections

0Hypotheses

1Analyses

9Outgoing

8Incoming

0Experiments

1Debates

Summary

Page for Beclin-1

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🔬 Protein Info

Gene Symbol	BECLIN
Chromosome	17q21
Molecular Weight	52 kDa
Amino Acids	450 aa
Exons	12
Pathways	PI3K
GeneCards	BECLIN
Human Protein Atlas	BECLIN
Interactions	ATG5, SIRT-1, VPS34
KG Connections	7 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Beclin-1

protein · 1419 words

→

Pathway Diagram

graph TD
    BECLIN_1["BECLIN-1"]
    BECLIN_1 -->|"activates"| autophagy["autophagy"]
    BECLIN_1 -->|"activates"| Autophagy["Autophagy"]
    BECLIN_1 -->|"activates"| VPS34["VPS34"]
    BECLIN_1 -->|"activates"| ST3GAL2["ST3GAL2"]
    BECLIN_1 -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
    BECLIN_1 -->|"references"| ULK1["ULK1"]
    ginseng_root_extract["ginseng root extract"] -->|"contributes to"| BECLIN_1
    AMPK["AMPK"] -->|"upstream_of"| BECLIN_1
    autophagy -->|"regulates"| BECLIN_1
    Autophagy -->|"interacts"| BECLIN_1
    mTOR["mTOR"] -->|"activates"| BECLIN_1
    ATG5["ATG5"] -->|"activates"| BECLIN_1

Outgoing (9)

Target	Relation	Type	Str
autophagy	activates	process	0.70
Autophagy	interacts_with	pathway	0.70
Autophagy	inhibits	pathway	0.70
Autophagy	activates	pathway	0.70
APOPTOSIS	causes	gene	0.70
VPS34	activates	protein	0.50
ST3GAL2	activates	concept	0.50
RAPAMYCIN	activates	concept	0.50
ULK1	references	gene	0.40

Incoming (8)

Source	Relation	Type	Str
ginseng root extract	contributes_to	drug	0.90
AMPK	upstream_of	gene	0.85
SIRT-1	activates	gene	0.80
autophagy	regulates	process	0.70
Autophagy	interacts_with	process	0.70
mTOR	activates	entity	0.50
ATG5	activates	gene	0.50
Autophagy	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What determines organelle-specific autophagy selectivity in neurodegenerative di

neurodegeneration | 2026-04-08 | 2 hypotheses Top: 0.580

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The review covers various organelle-specific autophagy types but doesn't address

closed · Rounds: 4 · Score: 0.66 · 2026-04-21

Related Research

Hypotheses and analyses mentioning BECLIN-1 in their description or question text

No additional research found