protein

BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF)

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF): its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

0Hypotheses

0Analyses

3Outgoing

0Incoming

0Experiments

0Debates

Summary

Page for Brain-Derived Neurotrophic Factor (BDNF)

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🔬 Protein Info

Gene Symbol	BRAIN
Full Name	DERIVED NEUROTROPHIC FACTOR (BDNF)
Target Class	Ligand
Mechanism of Action	Protein replacement therapy or small molecule mimetic
Druggability	Low (0.29)
Clinical Stage	Phase II
GeneCards	BRAIN
Human Protein Atlas	BRAIN
Associated Diseases	Addiction, ADHD, aging, allergic airway inflammation, Als
Known Drugs/Compounds	acupuncture, aducanumab, ANTIDEPRESSANTS, BAICALEIN, Bifidobacterium bifidum CCFM1163, Bnt162B2
Interactions	A2A receptor, A2A Receptor, ABCA7, ABETA, ACC, ACE
SciDEX Target	View Target Profile (4 clinical trials)
SciDEX Hypotheses	Hippocampal CA3-CA1 synaptic rescue via DHHC2-medi Hippocampal CA3-CA1 circuit rescue via neurogenesi BDNF-mediated hippocampal synaptic rescue as a mod (+3 more)
KG Connections	4748 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) — AlphaFold P23560 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

flowchart TD
    N0["Brain-Derived Neurotrophic Factor (BDNF)"]
    N1["GLP1R"]
    N0 -->|"references"| N1
    N2["CHR2"]
    N0 -->|"references"| N2
    N3["BDNF"]
    N0 -->|"references"| N3

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 gene
    class N2 gene
    class N3 gene

Outgoing (3)

Target	Relation	Type	Str
GLP1R	references	gene	0.40
CHR2	references	gene	0.40
BDNF	references	gene	0.40

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) in their description or question text

No additional research found