Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about C3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Cognitive Impairment | correlates_with | phenotype | 0.90 |
| C3AR | activates | protein | 0.90 |
| Neuronal Development | inhibits | process | 0.90 |
| C3AR1 | activates | protein | 0.87 |
| Dendritic Arborization | inhibits | process | 0.85 |
| INHIBITORY_SYNAPSE | disrupts | gene | 0.80 |
| C3AR | interacts_with | protein | 0.72 |
| MICROGLIAL_RECRUITMENT | activates | phenotype | 0.70 |
| MICROGLIAL_RECRUITMENT | causes | phenotype | 0.70 |
| COGNITIVE_IMPAIRMENT | associated_with | phenotype | 0.64 |
| M2_POLARIZATION | activates | phenotype | 0.64 |
| MICROGLIA | activates | cell_type | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate | 0.749 | alzheimers-disease-parkinsons | - |
| C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward | 0.651 | neuroinflammation | What molecular mechanisms determine whet |
| Complement Cascade Specificity: Microglial C3aR Antagonism D | 0.618 | synaptic-biology | Does SPP1-mediated synaptic engulfment r |
| Complement C3/C3aR Synaptic Protection Therapy | 0.000 | - | Immune atlas neuroinflammation analysis |
Scientific analyses that reference this entity
synaptic biology | 2026-04-07 | 17 hypotheses Top: 0.833
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| PINK1 mutation carriers frequently report experiencing pain. | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
| Evidence regarding pain in DNAJC6 pathogenic variants is limited and i | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
| Identification of a vulnerable subtype of dopaminergic neurons co-expr | genetic_association | Parkinson's disease | 0.500 | 0.00 | mouse | extracted | N/A |
| Evidence regarding pain in SYNJ1 pathogenic variants is limited and in | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
| Anxa1+ DANs show selective earlier loss compared to other dopaminergic | neuropathology | Parkinson's disease | 0.500 | 0.00 | mouse | extracted | N/A |
| Released prosaposin (PSAP) was shown to induce interleukin-6 (IL-6) up | cell_biology | Parkinson's disease | 0.500 | 0.00 | cell_culture | extracted | N/A |
| Evidence regarding pain in FBXO7 pathogenic variants is limited and in | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
| Evidence regarding pain in ATP13A2 pathogenic variants is limited and | genetic_association | Parkinson's disease | 0.500 | 0.00 | human | extracted | N/A |
| Inhibition of transmitter release specifically in Anxa1+ neurons was s | animal_model | Parkinson's disease | 0.500 | 0.00 | mouse | extracted | N/A |
| Identified a subtype of Sox6+ Anxa1+ dopaminergic neurons that are sel | neuropathology | Parkinson's disease | 0.500 | 0.00 | mouse | extracted | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning C3A in their description or question text
No additional research found