concept

C3AR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about C3AR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

4Hypotheses

3Analyses

15Outgoing

7Incoming

10Experiments

3Debates

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💡 Concept Info

Name	C3AR
Key Genes/Proteins	BETA_CATENIN, C3, C3A, GSK3B
Related Diseases	DENDRITIC_MORPHOLOGY

Wiki Pages (1)

Knowledge base pages for this entity

C3AR1 Gene

gene · 870 words

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Pathway Diagram

graph TD
    C3AR["C3AR"]
    C3AR -->|"modulates"| Neuronal_Apoptosis["Neuronal Apoptosis"]
    C3AR -->|"downregulates"| __catenin_Signaling["beta-catenin Signaling"]
    C3AR -->|"inhibits"| DENDRITIC_MORPHOLOGY["DENDRITIC_MORPHOLOGY"]
    C3AR -->|"activates"| MICROGLIA["MICROGLIA"]
    C3AR -->|"regulates"| BETA_CATENIN["BETA_CATENIN"]
    C3AR -->|"activates"| GSK3B["GSK3B"]
    C3["C3"] -->|"binds"| C3AR
    C3A["C3A"] -->|"binds"| C3AR
    Complement_C3["Complement C3"] -->|"interacts"| C3AR
    SB290157["SB290157"] -->|"inhibits"| C3AR

Outgoing (15)

Target	Relation	Type	Str
ASTROCYTES	mediates	cell_type	0.85
NEURON	mediates	cell_type	0.85
MICROGLIA	mediates	cell_type	0.85
ASTROCYTE	interacts_with	cell_type	0.80
neurodegeneration	therapeutic_target_for	disease	0.70
feedback loop	associated_with	phenotype	0.70
Synapse Engulfment	mediates	phenotype	0.70
synapse loss	mediates	phenotype	0.70
microglia	regulates	cell_type	0.70
Ad	targets	disease	0.70
MICROGLIA	activates	cell_type	0.64
DENDRITIC_MORPHOLOGY	inhibits	phenotype	0.64
cognitive impairment	associated_with	disease	0.60
GSK3B	activates	protein	0.56
BETA_CATENIN	regulates	protein	0.56

Incoming (7)

Source	Relation	Type	Str
C3	activates	protein	0.90
C3A	activates	protein	0.90
C3	interacts_with	protein	0.87
Complement C3	interacts_with	protein	0.80
C3A	interacts_with	protein	0.72
C3	activates	protein	0.72
SB290157	inhibits	drug	0.72

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte C3aR Signaling as Bifurcation Point for A1/A2 Fate	0.749	alzheimers-disease-parkinsons	-
C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward	0.651	neuroinflammation	What molecular mechanisms determine whet
Complement Cascade Specificity: Microglial C3aR Antagonism D	0.618	synaptic-biology	Does SPP1-mediated synaptic engulfment r
Complement C3/C3aR Synaptic Protection Therapy	0.000	-	Immune atlas neuroinflammation analysis

Mentioning Analyses (3)

Scientific analyses that reference this entity

Is C1q elevation in AD pathogenic or compensatory for amyloid clearance?

neurodegeneration | 2026-04-12 | 0 hypotheses

Does SPP1-mediated synaptic engulfment represent beneficial clearance or patholo

synaptic biology | 2026-04-07 | 8 hypotheses Top: 0.813

Microglia-astrocyte crosstalk amplification loops in neurodegeneration

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.729

Experiments (10)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Model	Status	Est. Cost
PINK1 mutation carriers frequently report experiencing pain.	genetic_association	Parkinson's disease	0.500	human	extracted	N/A
Evidence regarding pain in DNAJC6 pathogenic variants is limited and i	genetic_association	Parkinson's disease	0.500	human	extracted	N/A
Identification of a vulnerable subtype of dopaminergic neurons co-expr	genetic_association	Parkinson's disease	0.500	mouse	extracted	N/A
Evidence regarding pain in SYNJ1 pathogenic variants is limited and in	genetic_association	Parkinson's disease	0.500	human	extracted	N/A
Anxa1+ DANs show selective earlier loss compared to other dopaminergic	neuropathology	Parkinson's disease	0.500	mouse	extracted	N/A
Released prosaposin (PSAP) was shown to induce interleukin-6 (IL-6) up	cell_biology	Parkinson's disease	0.500	cell_culture	extracted	N/A
Evidence regarding pain in FBXO7 pathogenic variants is limited and in	genetic_association	Parkinson's disease	0.500	human	extracted	N/A
Evidence regarding pain in ATP13A2 pathogenic variants is limited and	genetic_association	Parkinson's disease	0.500	human	extracted	N/A
Inhibition of transmitter release specifically in Anxa1+ neurons was s	animal_model	Parkinson's disease	0.500	mouse	extracted	N/A
Identified a subtype of Sox6+ Anxa1+ dopaminergic neurons that are sel	neuropathology	Parkinson's disease	0.500	mouse	extracted	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

While SPP1 absence prevents synaptic loss, it's unclear whether this represents

closed · Rounds: 4 · Score: 0.69 · 2026-04-21

The debate revealed conflicting evidence about C1q's role - some studies show it

closed · Rounds: 4 · Score: 0.58 · 2026-04-16

Microglia activate astrocytes via IL-1alpha/TNF/C1q, and reactive astrocytes fee

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

Related Research

Hypotheses and analyses mentioning C3AR in their description or question text

No additional research found