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gene 3,023 words KG: MAP1LC3A
Contents

MAP1LC3A Gene

🧬 Gene Info
Gene SymbolMAP1LC3A
Chromosome20q11.22
Functionis a key structural component of the autophagosome, the double-membraned vesicle that engulfs cellular components for degradation and recycling [1].
Molecular Weight14.5 kDa
Amino Acids121 aa
Exons7
PathwaysAkt, Wnt
GeneCardsMAP1LC3A
Human Protein AtlasMAP1LC3A
Associated DiseasesAging, Cancer, Carcinoma, Cardiovascular, Hepatocellular Carcinoma, Ischemia
Known Drugs/Compoundsrapamycin
InteractionsAKT1, AKT1S1, AMBRA1, AMPK, APC, ATF6
SciDEX HypothesesAutophagosome Marker Hijacking Strategy
KG Connections493 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (13)

SASP-Mediated Complement Cascade Amplification
Score: 0.82APOE-Dependent Autophagy Restoration
Score: 0.89CYP46A1 Overexpression Gene Therapy
Score: 0.77Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Cross-Seeding Prevention Strategy
Score: 0.69Lysosomal Positioning Dynamics Modulation
Score: 0.69Complement C1QA Spatial Gradient in Cortical Layers
Score: 0.68Glycine-Rich Domain Competitive Inhibition
Score: 0.64Cryptic Exon Silencing Restoration
Score: 0.53RNA-Binding Competition Therapy for TDP-43 Cross-Seeding
Score: 0.47

Related Analyses (5)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedEpigenetic reprogramming in aging neurons
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (8)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40Macroautophagy Dysfunction in PD - Experiment Design
clinical · proposed · Score: 0.40

See Also (15)

ATP P2X3 Receptor Neurons
cell · KG edge: interacts_withAMPK (AMP-Activated Protein Kinase)
entity · KG edge: interacts_withApoptosis in Neurodegeneration
entity · KG edge: associated_withAutophagy Enhancement Drug Screening for Neurodegenerat
experiment · KG edge: associated_withAKT1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

OPTN interacts_with MAP1LC3A
CASP3 interacts_with MAP1LC3A
AKT1 interacts_with MAP1LC3A
CALCOCO2 interacts_with MAP1LC3A
CGAS interacts_with MAP1LC3A
CFTR interacts_with MAP1LC3A
SQSTM1 interacts_with MAP1LC3A
RPS6KB1 interacts_with MAP1LC3A
GRB2 interacts_with MAP1LC3A
RHEB interacts_with MAP1LC3A

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