gene 870 words KG: C3AR1 2026-03-22
kind:genesection:genesstate:published
Contents

C3AR1 Gene

🧬 Gene Info
Gene SymbolC3AR1
Full NameComplement C3a Receptor 1
Chromosome5p13.3
Protein TypeReceptor
FunctionC3AR1 encodes a seven-transmembrane G protein-coupled receptor that specifically binds the complement activation fragment C3a.
PathwaysBLOOD_CSF_BARRIER
UniProt IDQ16581
NCBI Gene ID719
Ensembl IDENSG00000171860
GeneCardsC3AR1
Human Protein AtlasC3AR1
Protein NameC3a anaphylatoxin chemotactic receptor
Associated DiseasesALS, Aging, Alzheimer, Cancer, Cardiovascular
Known Drugs/CompoundsSB290157
InteractionsC1QA, GRM2, CXCL12, CCR5, CNR2, CXCL8
KG Connections210 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (10)

SASP-Mediated Complement Cascade Amplification
Score: 0.70
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
CYP46A1 Overexpression Gene Therapy
Score: 0.63
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.52
GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.52

Related Analyses (6)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (7)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (11)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: activates
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: associated_with
C3 — Complement Component 3
gene · KG edge: activates

Knowledge Graph (12 edges)

C3AR1 regulates MOTOR_IMPAIRMENT
C3AR1 regulates BLOOD_CSF_BARRIER
C3AR1 regulates M2_POLARIZATION
C3AR1 regulates MICROGLIAL_RECRUITMENT
C3AR1 expressed_in GBM
C3AR1 biomarker_for RBPJL
C3AR1 regulates UNC13A
C3AR1 biomarker_for ANO9
C3AR1 biomarker_for TBK1
C3AR1 associated_with SIRT1