CASS2

Understanding Entity Pages

This page aggregates everything SciDEX knows about CASS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CASS2 (CRADD) is a death domain-containing adaptor protein that mediates caspase-2 activation and PIDDosome formation. It plays critical roles in apoptosis, necroptosis, and is implicated in Alzheimer's disease, Parkinson's disease, and ALS pathogenesis.

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graph TD
    CASS2["CASS2"]
    Alzheimer{"Alzheimer"}
    CASS2 -->|"associated_with"| Alzheimer
    Cancer{"Cancer"}
    CASS2 -->|"associated_with"| Cancer
    Autoimmune{"Autoimmune"}
    CASS2 -->|"associated_with"| Autoimmune
    Cell_Cycle(["Cell Cycle"])
    CASS2 -->|"associated_with"| Cell_Cycle
    AURKA["AURKA"]
    AURKA -->|"associated_with"| CASS2
    SRC["SRC"]
    SRC -->|"associated_with"| CASS2
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"associated_with"| CASS2
    CASS4["CASS4"]
    CASS4 -->|"associated_with"| CASS2
    AND["AND"]
    AND -->|"associated_with"| CASS2
    FYN["FYN"]
    FYN -->|"associated_with"| CASS2
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"associated_with"| CASS2
    CANCER["CANCER"]
    CANCER -->|"associated_with"| CASS2
    CASS2 -->|"interacts_with"| CASS4
    neurodegeneration["neurodegeneration"]
    CASS2 -->|"implicated_in"| neurodegeneration