AURKA

Understanding Entity Pages

This page aggregates everything SciDEX knows about AURKA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

AURKA is a protein involved in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with Aging, Als, Cancer. Connected to 57 entities in the SciDEX knowledge graph.

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graph TD
    AURKA["<b>AURKA</b>"]
    Survivin["Survivin"]
    AURKA -->|"upregulates"| Survivin
    Drug_Resistance["Drug Resistance"]
    AURKA -->|"associated with"| Drug_Resistance
    Gastric_Cancer{"Gastric Cancer"}
    AURKA -->|"associated with"| Gastric_Cancer
    FBXL7["FBXL7"]
    AURKA -->|"regulates"| FBXL7
    Apoptosis(["Apoptosis"])
    AURKA -->|"inhibits"| Apoptosis
    FOXP1["FOXP1"]
    AURKA -->|"interacts with"| FOXP1
    Cancer{"Cancer"}
    AURKA -->|"activates"| Cancer
    Aging{"Aging"}
    AURKA -->|"activates"| Aging
    Als{"Als"}
    AURKA -->|"inhibits"| Als
    AURKA -->|"regulates"| FOXP1
    Ubiquitin_Proteasome(["Ubiquitin-Proteasome"])
    AURKA -->|"activates"| Ubiquitin_Proteasome
    Proteasome(["Proteasome"])
    AURKA -->|"activates"| Proteasome
    EGF["EGF"]
    EGF -->|"inhibits"| AURKA
    IGF1["IGF1"]
    IGF1 -->|"inhibits"| AURKA
    PI3K["PI3K"]
    PI3K -->|"inhibits"| AURKA
    FOXP1 -->|"regulates"| AURKA
    DNA["DNA"]
    DNA -->|"activates"| AURKA
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"activates"| AURKA
    CANCER["CANCER"]
    CANCER -->|"activates"| AURKA
    style AURKA fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0