gene

CCR3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

16Connections
0Hypotheses
0Analyses
11Outgoing
5Incoming

Summary

C-C Chemokine Receptor Type 3, a GPCR involved in eosinophil recruitment and neuroinflammation

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🧬 Gene Info
Gene SymbolCCR3
Full NameC-C Chemokine Receptor Type 3
AliasesCD193, Eosinophil CCR3, Eotaxin receptor
Chromosome3p21.31
Protein TypeReceptor
Functionis a G protein-coupled receptor (GPCR) that serves as the primary receptor for eotaxin family chemokines (CCL11, CCL24, CCL26) and other CC chemokines including RANTES (CCL5) and MCP-3 (CCL7)[@dami...
Primary Expressionthe central nervous system (CNS) on astrocytes and microglia, where it contributes to neuroinflammatory processes in neurodegenerative diseases[@furuy
Molecular Weight~40 kDa
Amino Acids355 aa
PathwaysPI3K Pathway, MAPK Pathway
UniProt IDP51671
NCBI Gene ID1232
Ensembl IDENSG00000183625
OMIM601837
GeneCardsCCR3
Human Protein AtlasCCR3
Associated DiseasesAlzheimer's disease, Parkinson's disease
InteractionsCCL5, CX3CL1, CX3CR1, CXCL12, CXCL8, CXCR1
KG Connections16 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CCR3 — AlphaFold P51671 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

CCR3 Gene

gene · 987 words

CCL5 Protein

protein · 1174 words

CCL5 — C-C Motif Chemokine Ligand 5

gene · 1022 words

CCL2 Protein

redirect · 650 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    N0["CCR3"]
    N1["oligodendroglial deficits"]
    N0 -->|"activates"| N1
    N2["Asthma"]
    N0 -->|"interacts with"| N2
    N3["Inflammation"]
    N0 -->|"interacts with"| N3
    N4["CCL5"]
    N0 -->|"interacts with"| N4
    N5["CCR8"]
    N5 -->|"interacts with"| N0
    N6["CYTOKINES"]
    N6 -->|"interacts with"| N0
    N7["INFLAMMATION"]
    N7 -->|"interacts with"| N0
    N8["CCL2"]
    N8 -->|"interacts with"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N2 disease
    class N3 disease
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 gene
    class N8 gene

Outgoing (11)

TargetRelationTypeStr
oligodendroglial deficitsactivatesprocess0.70
Asthmainteracts_withdisease0.65
Inflammationinteracts_withdisease0.65
CCL5interacts_withgene0.60
CX3CL1interacts_withgene0.60

Incoming (5)

SourceRelationTypeStr
CCR8interacts_withgene0.60
CCR2interacts_withgene0.60
CYTOKINESinteracts_withgene0.60
INFLAMMATIONinteracts_withgene0.60
CCL2interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found