Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
C-C Chemokine Receptor Type 3, a GPCR involved in eosinophil recruitment and neuroinflammation
| Gene Symbol | CCR3 |
| Full Name | C-C Chemokine Receptor Type 3 |
| Aliases | CD193, Eosinophil CCR3, Eotaxin receptor |
| Chromosome | 3p21.31 |
| Protein Type | Receptor |
| Function | is a G protein-coupled receptor (GPCR) that serves as the primary receptor for eotaxin family chemokines (CCL11, CCL24, CCL26) and other CC chemokines including RANTES (CCL5) and MCP-3 (CCL7)[@dami... |
| Primary Expression | the central nervous system (CNS) on astrocytes and microglia, where it contributes to neuroinflammatory processes in neurodegenerative diseases[@furuy |
| Molecular Weight | ~40 kDa |
| Amino Acids | 355 aa |
| Pathways | PI3K Pathway, MAPK Pathway |
| UniProt ID | P51671 |
| NCBI Gene ID | 1232 |
| Ensembl ID | ENSG00000183625 |
| OMIM | 601837 |
| GeneCards | CCR3 |
| Human Protein Atlas | CCR3 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | CCL5, CX3CL1, CX3CR1, CXCL12, CXCL8, CXCR1 |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["CCR3"]
N1["oligodendroglial deficits"]
N0 -->|"activates"| N1
N2["Asthma"]
N0 -->|"interacts with"| N2
N3["Inflammation"]
N0 -->|"interacts with"| N3
N4["CCL5"]
N0 -->|"interacts with"| N4
N5["CCR8"]
N5 -->|"interacts with"| N0
N6["CYTOKINES"]
N6 -->|"interacts with"| N0
N7["INFLAMMATION"]
N7 -->|"interacts with"| N0
N8["CCL2"]
N8 -->|"interacts with"| N0
N9["neurodegeneration"]
N0 -->|"implicated in"| N9
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N2 disease
class N3 disease
class N4 gene
class N5 gene
class N6 gene
class N7 gene
class N8 gene| Target | Relation | Type | Str |
|---|---|---|---|
| oligodendroglial deficits | activates | process | 0.70 |
| Asthma | interacts_with | disease | 0.65 |
| Inflammation | interacts_with | disease | 0.65 |
| CCL5 | interacts_with | gene | 0.60 |
| CX3CL1 | interacts_with | gene | 0.60 |
| CX3CR1 | interacts_with | gene | 0.60 |
| CXCL12 | interacts_with | gene | 0.60 |
| CXCL8 | interacts_with | gene | 0.60 |
| CXCR1 | interacts_with | gene | 0.60 |
| CXCR4 | interacts_with | gene | 0.60 |
| macrophages | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CCR8 | interacts_with | gene | 0.60 |
| CCR2 | interacts_with | gene | 0.60 |
| CYTOKINES | interacts_with | gene | 0.60 |
| INFLAMMATION | interacts_with | gene | 0.60 |
| CCL2 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||