CXCR4

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCR4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CXCR4 (C-X-C chemokine receptor type 4) is a GPCR for CXCL12 (SDF-1) that plays essential roles in brain development, neural stem cell migration, hematopoiesis, immune cell trafficking, and cancer metastasis. Mutations cause WHIM syndrome

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graph TD
    CXCR4["CXCR4"]
    CXCR4 -->|"activates"| Diabetes["Diabetes"]
    CXCR4 -->|"activates"| Als["Als"]
    CXCR4 -->|"activates"| Hypertension["Hypertension"]
    CXCR4 -->|"activates"| Atherosclerosis["Atherosclerosis"]
    CXCR4 -->|"activates"| Aging["Aging"]
    CXCR4 -->|"activates"| Ms["Ms"]
    CXCR4 -->|"regulates"| Inflammation["Inflammation"]
    CXCR4 -->|"regulates"| Tauopathy["Tauopathy"]
    CXCR4 -->|"target for"| Alzheimer["Alzheimer"]
    CXCR4 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    DDX5["DDX5"] -->|"regulates"| CXCR4
    NLRP3["NLRP3"] -->|"regulates"| CXCR4
    AGING["AGING"] -->|"inhibits"| CXCR4
    INFLAMMATION["INFLAMMATION"] -->|"activates"| CXCR4
    CXCL2["CXCL2"] -->|"activates"| CXCR4
    BMAL1["BMAL1"] -->|"activates"| CXCR4
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| CXCR4
    NF__B["NF-KappaB"] -->|"regulates"| CXCR4
    TAU_PATHOLOGY["TAU PATHOLOGY"] -->|"target for"| CXCR4
    TAU["TAU"] -->|"regulates"| CXCR4