gene

CXCR4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCR4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

302Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

CXCR4 (C-X-C chemokine receptor type 4) is a GPCR for CXCL12 (SDF-1) that plays essential roles in brain development, neural stem cell migration, hematopoiesis, immune cell trafficking, and cancer metastasis. Mutations cause WHIM syndrome

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🧬 Gene Info

Gene Symbol	CXCR4
Aliases	C-X-C chemokine receptor type 4
Chromosome	2q22.1
Protein Type	Receptor
Function	CXCR4 has diverse physiological roles
Molecular Weight	39.8 kDa
Amino Acids	352 aa
Pathways	NF-κB, PI3K, MAPK pathway, MAPK
GeneCards	CXCR4
Human Protein Atlas	CXCR4
Seven transmembrane helices (TM1-7)	Form the ligand-binding pocket
N-terminal domain	Contains sulfated tyrosine residues critical for CXCL12 binding
C-terminal tail	Contains phosphorylation sites for β-arrestin recruitment and desensitization
Extracellular loops (ECL1-3)	Contribute to ligand specificity
Intracellular loops (ICL1-3)	Mediate G protein coupling (primarily Gi/o)
Associated Diseases	Als, Alzheimer, Autoimmune, Breast Cancer, Cancer, dementia
Interactions	AGING, ALZHEIMER'S DISEASE, APOE, APOPTOSIS, APP, AUTOPHAGY
KG Connections	302 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CXCR4["CXCR4"]
    CXCR4 -->|"activates"| Diabetes["Diabetes"]
    CXCR4 -->|"activates"| Als["Als"]
    CXCR4 -->|"activates"| Hypertension["Hypertension"]
    CXCR4 -->|"activates"| Atherosclerosis["Atherosclerosis"]
    CXCR4 -->|"activates"| Aging["Aging"]
    CXCR4 -->|"activates"| Ms["Ms"]
    CXCR4 -->|"regulates"| Inflammation["Inflammation"]
    CXCR4 -->|"regulates"| Tauopathy["Tauopathy"]
    CXCR4 -->|"target for"| Alzheimer["Alzheimer"]
    CXCR4 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    DDX5["DDX5"] -->|"regulates"| CXCR4
    NLRP3["NLRP3"] -->|"regulates"| CXCR4
    AGING["AGING"] -->|"inhibits"| CXCR4
    INFLAMMATION["INFLAMMATION"] -->|"activates"| CXCR4
    CXCL2["CXCL2"] -->|"activates"| CXCR4
    BMAL1["BMAL1"] -->|"activates"| CXCR4
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"target for"| CXCR4
    NF__B["NF-KappaB"] -->|"regulates"| CXCR4
    TAU_PATHOLOGY["TAU PATHOLOGY"] -->|"target for"| CXCR4
    TAU["TAU"] -->|"regulates"| CXCR4

Outgoing (173)

Target	Relation	Type	Str
Als	activates	disease	0.85
Inflammation	associated_with	disease	0.85
immunosuppressive cell infiltration	promotes	process	0.85
Cancer	associated_with	disease	0.75
Cancer	expressed_in	disease	0.75
Als	associated_with	disease	0.75
GENES	associated_with	gene	0.70
INFLAMMATION	associated_with	gene	0.70
Inflammation	regulates	disease	0.65
Prostate Cancer	implicated_in	disease	0.65
Breast Cancer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Chronic Kidney Disease	activates	disease	0.65
Tauopathy	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
Traumatic Brain Injury	treats	disease	0.65
Ms	activates	disease	0.65
Aging	activates	disease	0.65
Neurodegeneration	treats	disease	0.65
Ms	therapeutic_target	disease	0.65
Heart Failure	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Neuroinflammation	regulates	disease	0.65
Aging	inhibits	disease	0.65
Lymphoma	biomarker_for	disease	0.65
Cancer	encodes	disease	0.65
Tumor	associated_with	disease	0.65
Leukemia	associated_with	disease	0.65
Als	biomarker_for	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Inflammation	expressed_in	disease	0.65
Ms	associated_with	disease	0.65
Lymphoma	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Diabetes	activates	disease	0.65
Inflammation	activates	disease	0.65
Hypertension	activates	disease	0.65
Atherosclerosis	activates	disease	0.65
Obesity	expressed_in	disease	0.65
Tumor	inhibits	disease	0.65
Osteoporosis	activates	disease	0.65
Autoimmune	associated_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Dementia	expressed_in	disease	0.65
ALS	expressed_in	disease	0.65
ALS	activates	disease	0.65
Traumatic Brain Injury	activates	disease	0.65
CCL5	activates	gene	0.60

Incoming (129)

Source	Relation	Type	Str
Cxcl12	binds	protein	0.95
CCL2	regulates	gene	0.70
radiation	upregulates	process	0.70
BMAL1	activates	gene	0.60
TAU	regulates	gene	0.60
STING	regulates	gene	0.60
TREM2	inhibits	gene	0.60
APOE	inhibits	gene	0.60
TREM2	associated_with	gene	0.60
CD44	regulates	gene	0.60
BCL2	associated_with	gene	0.60
LGALS3	associated_with	gene	0.60
AKT	associated_with	gene	0.60
GNAL	expressed_in	gene	0.60
VAMP7	activates	gene	0.60
MMP9	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
AKT1	expressed_in	gene	0.60
MCC	expressed_in	gene	0.60
CD44	activates	gene	0.60
CASP1	expressed_in	gene	0.60
MYD88	expressed_in	gene	0.60
TPM3	expressed_in	gene	0.60
TNF	expressed_in	gene	0.60
RIPK1	expressed_in	gene	0.60
TNFRSF1A	expressed_in	gene	0.60
REELIN	activates	gene	0.60
MTOR	activates	gene	0.60
CCR5	activates	gene	0.60
ANGPT1	associated_with	gene	0.60
PSD95	activates	gene	0.60
CD44	expressed_in	gene	0.60
CCL2	interacts_with	gene	0.60
APP	interacts_with	gene	0.60
BCL2L1	interacts_with	gene	0.60
CDKN1B	interacts_with	gene	0.60
CTNNB1	interacts_with	gene	0.60
CD44	interacts_with	gene	0.60
APP	targets	gene	0.60
BCL2L1	targets	gene	0.60
CD44	targets	gene	0.60
CDKN1B	targets	gene	0.60
CTNNB1	targets	gene	0.60
CCR2	interacts_with	gene	0.60
CCR3	interacts_with	gene	0.60
CX3CL1	interacts_with	gene	0.60
CX3CR1	interacts_with	gene	0.60
CXCL8	interacts_with	gene	0.60
CXCR1	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does pericyte senescence mechanistically promote glioma cell growth and inva

neurodegeneration | 2026-04-14 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract reports that pericyte senescence contributes to glioma growth and i

closed · Rounds: 4 · Score: 0.95 · 2026-04-16

Related Research

Hypotheses and analyses mentioning CXCR4 in their description or question text

No additional research found