cell_type

macrophages

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about macrophages: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1875Connections

0Hypotheses

1Analyses

25Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	macrophages
Definition	<table class="infobox infobox-cell">
Key Markers	AMYLOID-BETA 42 FIBRILS, ANXA1, LOX, ABCA7, TREM2, LGALS9, DCLK1, HMGB1
Key Pathways	IL-4-STAT6 pathway, NF-kB signaling, ferroptosis, PI3K-AKT-mTOR signaling, pyroptosis
Associated Diseases	Cardiovascular Disease, Acute Ischemic Stroke, Atherosclerosis, Periodontitis, neurodegeneration, aging
Linked Hypotheses	121 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    macrophages["macrophages"] -->|"expressed in"| LC3_associated_phagocytosis["LC3-associated phagocytosis"]
    style LC3_associated_phagocytosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    macrophages["macrophages"] -->|"activates"| phagocytosis["phagocytosis"]
    style phagocytosis fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    macrophages["macrophages"] -->|"regulates"| neuroinflammatory_responses["neuroinflammatory responses"]
    style neuroinflammatory_responses fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    macrophages["macrophages"] -->|"activates"| glioblastoma["glioblastoma"]
    style glioblastoma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    macrophages["macrophages"] -->|"regulates"| stroke["stroke"]
    style stroke fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    macrophages["macrophages"] -->|"associated"| ER_stress["ER stress"]
    style ER_stress fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    macrophages["macrophages"] -->|"protects against"| neuroinflammation["neuroinflammation"]
    style neuroinflammation fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"expressed in"| macrophages["macrophages"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    DCLK1["DCLK1"] -->|"expressed in"| macrophages["macrophages"]
    style DCLK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IL_4_STAT6_pathway["IL-4-STAT6 pathway"] -->|"protects against"| macrophages["macrophages"]
    style IL_4_STAT6_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    neuroinflammation_1["neuroinflammation"] -->|"affects"| macrophages["macrophages"]
    style neuroinflammation_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    unfolded_protein_response["unfolded protein response"] -->|"active in"| macrophages["macrophages"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    style macrophages fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (550)

Target	Relation	Type	Str
LC3-associated phagocytosis	expressed_in	process	0.90
phagocytosis	activates	process	0.90
neuroinflammation	modulates	process	0.90
systemic inflammation	mediates	process	0.88
lesion formation	drives	process	0.85
pro-inflammatory signaling	activates	pathway	0.85
neuroinflammatory responses	regulates	process	0.70
glioblastoma	activates	disease	0.70
phagocytosis	regulates	process	0.60
stroke	regulates	disease	0.60
ER stress	associated_with	process	0.60
neuroinflammation	protects_against	disease	0.60
ferroptosis	regulates	process	0.60
phagocytosis	interacts_with	process	0.60
Alzheimer's disease	implicated_in	disease	0.60
phagocytosis	inhibits	process	0.60
pyroptosis	inhibits	process	0.60
multiple sclerosis	associated_with	disease	0.60
ferroptosis	activates	process	0.60
stroke	activates	disease	0.60
neuroinflammation	implicated_in	disease	0.60
amyloid aggregation	protects_against	process	0.60
unfolded protein response	active_in	pathway	0.55
blood-brain barrier	active_in	pathway	0.55
insulin signaling	active_in	pathway	0.55

Incoming (1325)

Source	Relation	Type	Str
TREM2	expressed_in	gene	0.95
DCLK1	expressed_in	gene	0.90
IL-4-STAT6 pathway	protects_against	pathway	0.90
neuroinflammation	affects	disease	0.90
unfolded protein response	active_in	pathway	0.90
NF-kB signaling	active_in	pathway	0.90
ferroptosis	active_in	pathway	0.90
stroke	affects	disease	0.90
PI3K-AKT-mTOR signaling	active_in	pathway	0.90
neurodegeneration	affects	disease	0.90
Alzheimer's disease	affects	disease	0.90
glioblastoma	affects	disease	0.90
pyroptosis	active_in	pathway	0.90
NLRP3	activates	gene	0.90
aging	affects	disease	0.90
TNF	expressed_in	gene	0.90
spinal muscular atrophy	affects	disease	0.90
CCR2	expressed_in	gene	0.90
FK866	suppresses	drug	0.85
diabetes	affects	disease	0.80
RNA	inhibits	gene	0.80
STING	activates	gene	0.80
RNA	activates	gene	0.80
STING	regulates	gene	0.80
lipid metabolism	active_in	pathway	0.80
TNF	activates	gene	0.80
TNF	inhibits	gene	0.80
AKT	regulates	gene	0.80
GBM	inhibits	gene	0.80
AKT	activates	gene	0.80
PI3K	regulates	gene	0.80
RNA	associated_with	gene	0.80
NLRP3	causes	gene	0.80
TGF-beta signaling	active_in	pathway	0.80
LDL	expressed_in	gene	0.80
CD14	expressed_in	gene	0.80
CD68	expressed_in	gene	0.80
CCL2	expressed_in	gene	0.80
AKT	expressed_in	gene	0.80
C1Q	expressed_in	gene	0.80
LRRK2	expressed_in	gene	0.80
CD33	expressed_in	gene	0.80
cGAS-STING	active_in	pathway	0.80
CR1	expressed_in	gene	0.80
CD19	expressed_in	gene	0.80
THBS1	expressed_in	gene	0.80
APRIL	limits_accumulation	protein	0.80
Senescent Red Blood Cells	associated_with	cell	0.80
EPSIN1	expressed_in	gene	0.75
EPSIN2	expressed_in	gene	0.75

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

macrophages

Understanding Entity Pages

Wiki Pages (20)

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