Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| peripheral immune cell recruitment | regulates | process | 0.90 |
| macrophages | expressed_in | cell_type | 0.90 |
| Blood-Brain Barrier | regulates | brain_region | 0.90 |
| Pro-Inflammatory Monocyte Trafficking | involved_in | process | 0.85 |
| Immune Cell Recruitment | regulates | process | 0.85 |
| microglia | expressed_in | cell_type | 0.80 |
| Monocyte Infiltration | promotes | process | 0.75 |
| cytokine amplification | involved_in | process | 0.75 |
| blood brain barrier | activates | cell_type | 0.70 |
| CXCR3 | expressed_in | gene | 0.70 |
| CX3CR1 | associated_with | gene | 0.70 |
| blood-brain barrier | participates_in | pathway | 0.70 |
| NF-kB signaling | participates_in | pathway | 0.70 |
| oxidative stress response | participates_in | pathway | 0.70 |
| CCR5 | expressed_in | gene | 0.60 |
| CXCL10 | expressed_in | gene | 0.60 |
| FGF2 | associated_with | gene | 0.60 |
| HIF1A | associated_with | gene | 0.60 |
| ICAM1 | associated_with | gene | 0.60 |
| IL13 | associated_with | gene | 0.60 |
| MRC1 | associated_with | gene | 0.60 |
| NLRP3 | associated_with | gene | 0.60 |
| PPARG | associated_with | gene | 0.60 |
| CCR3 | interacts_with | gene | 0.60 |
| CX3CL1 | interacts_with | gene | 0.60 |
| CX3CR1 | interacts_with | gene | 0.60 |
| CXCL12 | interacts_with | gene | 0.60 |
| CXCL8 | interacts_with | gene | 0.60 |
| CXCR1 | interacts_with | gene | 0.60 |
| CXCR4 | interacts_with | gene | 0.60 |
| CX3CL1 | regulates | gene | 0.60 |
| CX3CR1 | regulates | gene | 0.60 |
| CXCL12 | regulates | gene | 0.60 |
| CXCR4 | regulates | gene | 0.60 |
| CD68 | associated_with | gene | 0.60 |
| P2RY12 | associated_with | gene | 0.60 |
| neuroinflammation | causes | disease | 0.60 |
| CR1 | interacts_with | gene | 0.60 |
| CD8 | expressed_in | gene | 0.60 |
| PD1 | expressed_in | gene | 0.60 |
| STAT1 | phosphorylates | gene | 0.60 |
| stroke | inhibits | disease | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| TLR4 | regulates | gene | 0.60 |
| CD8 | activates | gene | 0.60 |
| SLAMF7 | inhibits | gene | 0.60 |
| CSF1R | activates | gene | 0.60 |
| IL1R1 | activates | gene | 0.60 |
| TNFR1 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CCL2 | binds | protein | 0.90 |
| CCL2 | interacts_with | gene | 0.90 |
| CCL2 | activates | gene | 0.90 |
| CCL2 | inhibits | gene | 0.90 |
| CCL2 | regulates | gene | 0.80 |
| CCL2 | associated_with | gene | 0.80 |
| CCL2 | targets | gene | 0.80 |
| CCL2 | implicated_in | gene | 0.70 |
| CCL3 | expressed_in | gene | 0.60 |
| CCR1 | expressed_in | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| CASP1 | associated_with | gene | 0.60 |
| AQP4 | activates | gene | 0.60 |
| AQP4 | inhibits | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| ASC | activates | gene | 0.60 |
| ATF3 | activates | gene | 0.60 |
| ATG5 | activates | gene | 0.60 |
| CCL2 | expressed_in | gene | 0.60 |
| CCL2 | causes | gene | 0.60 |
| CCL2 | phosphorylates | gene | 0.60 |
| CCL2 | cleaves | gene | 0.60 |
| ASK1 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||