concept

CCR2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

12Hypotheses

4Analyses

50Outgoing

20Incoming

0Experiments

7Debates

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💡 Concept Info

Name	CCR2
Key Genes/Proteins	AKT, APOE, AQP4, ASC, ASK1, ATF3
Related Diseases	AD
Related Pathways	apoptosis pathway, autophagy pathway, blood-brain barrier
Linked Hypotheses	10 hypotheses

Wiki Pages (1)

Knowledge base pages for this entity

CCR2 and CCR5 Antagonists for Neurodegeneration

therapeutic · 844 words

→

Pathway Diagram

graph TD
    CCR2[CCR2]
    CCR2 -->|regulates| peripheral_immune_cell_recruit[peripheral immune cell recruitment]
    CCR2 -->|expressed in| macrophages[macrophages]
    CCR2 -->|regulates| Blood_Brain_Barrier[Blood-Brain Barrier]
    CCR2 -->|involved_in| Pro_Inflammatory_Monocyte_Traf[Pro-Inflammatory Monocyte Trafficking]
    CCR2 -->|regulates| Immune_Cell_Recruitment[Immune Cell Recruitment]
    CCR2 -->|expressed in| microglia[microglia]
    CCR2 -->|promotes| Monocyte_Infiltration[Monocyte Infiltration]
    CCR2 -->|involved_in| cytokine_amplification[cytokine amplification]
    CCR2 -->|activates| blood_brain_barrier[blood brain barrier]
    CCR2 -->|expressed in| CXCR3[CXCR3]
    CCL2[CCL2] -->|binds| CCR2
    CCL3[CCL3] -->|expressed in| CCR2
    CCR1[CCR1] -->|expressed in| CCR2
    AQP4[AQP4] -->|activates| CCR2

Outgoing (87)

Target	Relation	Type	Str
Blood-Brain Barrier	regulates	brain_region	0.90
macrophages	expressed_in	cell_type	0.90
peripheral immune cell recruitment	regulates	process	0.90
monocyte trafficking to CNS	regulates	process	0.90
AD	therapeutic_target_for	disease	0.90
Immune Cell Recruitment	regulates	process	0.85
Pro-Inflammatory Monocyte Trafficking	involved_in	process	0.85
microglia	expressed_in	cell_type	0.80
cytokine amplification	involved_in	process	0.75
Monocyte Infiltration	promotes	process	0.75
blood brain barrier	activates	cell_type	0.70
CX3CR1	associated_with	gene	0.70
blood-brain barrier	participates_in	pathway	0.70
NF-kB signaling	participates_in	pathway	0.70
CXCR3	expressed_in	gene	0.70
Monocyte recruitment	regulates	mechanism	0.70
perivascular proteolytic phenotype	regulates	phenotype	0.70
oxidative stress response	participates_in	pathway	0.70
LAMP2	activates	gene	0.60
LC3	activates	gene	0.60
MLKL	activates	gene	0.60
NLRP3	activates	gene	0.60
NMDAR	activates	gene	0.60
glioblastoma	interacts_with	disease	0.60
JAK	causes	gene	0.60
JAK-STAT signaling	participates_in	pathway	0.60
CHOP	activates	gene	0.60
IRAK1	activates	gene	0.60
ISG15	activates	gene	0.60
JNK	activates	gene	0.60
CXCL9	expressed_in	gene	0.60
MAPK	inhibits	gene	0.60
MAPK signaling	participates_in	pathway	0.60
endothelial cells	expressed_in	cell_type	0.60
apoptosis pathway	participates_in	pathway	0.60
Wnt signaling	participates_in	pathway	0.60
T cells	expressed_in	cell_type	0.60
TGF	activates	gene	0.60
TGF-beta signaling	participates_in	pathway	0.60
stem cells	expressed_in	cell_type	0.60
traumatic brain injury	associated_with	disease	0.60
ERK	activates	gene	0.60
IFN	activates	gene	0.60
MAPK	activates	gene	0.60
NLR	activates	gene	0.60
RNA	activates	gene	0.60
autophagy pathway	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
IRS1	associated_with	gene	0.60
IL13	associated_with	gene	0.60

Incoming (20)

Source	Relation	Type	Str
CCL2	activates	gene	0.90
CCL2	inhibits	gene	0.90
CCL2	interacts_with	gene	0.90
CCL2	associated_with	protein	0.90
CCL2	regulates	gene	0.80
CCL2	targets	gene	0.80
CCL2	expressed_in	gene	0.60
CCL2	phosphorylates	gene	0.60
CCL2	causes	gene	0.60
ASK1	activates	gene	0.60
AQP4	activates	gene	0.60
AQP4	inhibits	gene	0.60
CCL3	expressed_in	gene	0.60
CCR1	expressed_in	gene	0.60
APOE	associated_with	gene	0.60
CASP1	associated_with	gene	0.60
AKT	activates	gene	0.60
ASC	activates	gene	0.60
ATF3	activates	gene	0.60
ATG5	activates	gene	0.60

Targeting Hypotheses (12)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Peripheral Monocyte/Macrophage Infiltration Mimicking Microg	0.743	neuroinflammation	What causes IBA1 low/negative microglia
CCL2-CCR2 Driven Macrophage Infiltration Selectively Strips	0.682	als	CCL2-CCR2 Axis at NMJ: Mechanism of Sele
CCL2-CCR2 myeloid signaling as a selective driver of fast-fa	0.626	neurodegeneration	CCL2-CCR2 Axis at NMJ: Mechanism of Sele
Cell-state stratification is required to resolve CCL2-CCR2 A	0.612	neurodegeneration	CCL2-CCR2 Axis at NMJ: Mechanism of Sele
Perturbation-first validation should precede therapeutic cla	0.608	neurodegeneration	CCL2-CCR2 Axis at NMJ: Mechanism of Sele

Microglial Replacement and Ontogeny Shift	0.590	developmental-neurobiology	Do perinatal immune challenges create pe
CCR2+ Monocyte Depletion as Restoration of CNS Immune Privil	0.501	immunomics	Systemic immune profiling in neurodegene
CCR2+ Monocyte Reprogramming via IL-10 Enhancement for CNS I	0.380	immunomics	Systemic immune profiling in neurodegene
CRP-Mediated CCR2+ Monocyte Recruitment Drives Microglial IL	0.380	immunomics	Systemic immune profiling in neurodegene
CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metab	0.380	developmental-neurobiology	Do perinatal immune challenges create pe
hs-CRP-Driven CCR2+ Monocyte Recruitment Disrupts CNS Immune	0.357	immunomics	Systemic immune profiling in neurodegene
CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metab	0.351	developmental-neurobiology	Do perinatal immune challenges create pe

Mentioning Analyses (4)

Scientific analyses that reference this entity

CCL2-CCR2 Axis at NMJ: Mechanism of Selective Motor Neuron Vulnerability in ALS

neurodegeneration | 2026-04-27 | 4 hypotheses Top: 0.682

What are the specific molecular mechanisms by which peripheral monocytes cross t

neurodegeneration | 2026-04-13 | 1 hypotheses Top: 0.620

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

neurodegeneration | 2026-04-12 | 0 hypotheses

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 1 hypotheses Top: 0.380

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (3)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
mTOR Signaling Pathway Regulates the Release of Proinflammatory Molecule CCL5 Im [PMID:35422816]	Unknown	Front Immunol	2022
Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model o [PMID:33127853]	Unknown	J Neurosci	2020
Focal brain inflammation and autism. [PMID:23570274]	Unknown	J Neuroinflammation	2013

Debates (7)

Multi-agent debates referencing this entity

How does the CCL2-CCR2 chemokine axis at the neuromuscular junction drive select

closed · Rounds: 4 · Score: 0.67 · 2026-04-28

The debate outlined peripheral immune involvement but failed to address the prec

closed · Rounds: 4 · Score: 0.78 · 2026-04-14

The debate outlined peripheral immune involvement but failed to address the prec

closed · Rounds: 4 · Score: 0.67 · 2026-04-14

How do peripheral immune system alterations influence CNS pathology and neurodeg

closed · Rounds: 4 · Score: 0.76 · 2026-04-12

How do peripheral immune system alterations influence CNS pathology and neurodeg

closed · Rounds: 4 · Score: 0.78 · 2026-04-12

Do bacterial curli amyloids cross the blood-brain barrier to directly seed α-syn

closed · Rounds: 4 · Score: 0.84 · 2026-04-12

How do peripheral immune system alterations influence CNS pathology and neurodeg

closed · Rounds: 4 · Score: 0.50 · 2026-04-11

Related Research

Hypotheses and analyses mentioning CCR2 in their description or question text

Microglial Replacement and Ontogeny Shift

Score: 0.590 · developmental-neurobiology · 2026-04-21

**Molecular Mechanism and Rationale** The molecular foundation of microglial replacement and ontogeny shift centers on

CCR2+ Monocyte Depletion as Restoration of CNS Immune Privilege

Score: 0.501 · immunomics · 2026-04-25

CCR2+ Monocyte Depletion as Restoration of CNS Immune Privilege

CCR2+ Monocyte Reprogramming via IL-10 Enhancement for CNS Immune Privilege Rest

Score: 0.380 · immunomics · 2026-04-26

Rather than depleting CCR2+ monocytes, this hypothesis proposes reprogramming their phenotype through targeted IL-10 pat

CRP-Mediated CCR2+ Monocyte Recruitment Drives Microglial IL-1β Amplification an

Score: 0.380 · immunomics · 2026-04-27

This hypothesis proposes that circulating hs-CRP directly recruits CCR2+ monocytes to the CNS through upregulation of CC

CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metabolic Reprogramming i

Score: 0.380 · developmental-neurobiology · 2026-04-27

This hypothesis proposes that perinatal immune activation triggers CCR2-dependent recruitment of bone marrow-derived mon

hs-CRP-Driven CCR2+ Monocyte Recruitment Disrupts CNS Immune Privilege via IL-1β

Score: 0.357 · immunomics · 2026-04-26

Circulating hs-CRP directly triggers CCR2+ monocyte recruitment to the CNS by enhancing CCL2 expression in brain endothe

CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metabolic Reprogramming i

Score: 0.351 · developmental-neurobiology · 2026-04-26

This hypothesis proposes that perinatal immune activation triggers a two-phase pathogenic cascade where CCR2-mediated re