gene

CXCR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

99Connections

0Hypotheses

0Analyses

50Outgoing

31Incoming

Summary

C-X-C Motif Chemokine Receptor 1, a GPCR for IL-8 involved in neuroinflammation and neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	CXCR1
Full Name	C-X-C Motif Chemokine Receptor 1
Aliases	IL8RA, IL-8R1, CD128, CD181
Chromosome	2q35
Protein Type	Receptor
Function	is a G protein-coupled receptor (GPCR) that specifically binds interleukin-8 (IL-8/CXCL8) and granulocyte colony-stimulating factor (G-CSF)[@liu2019].
Molecular Weight	~40 kDa
Amino Acids	350 aa
Pathways	PI3K, MAPK
UniProt ID	P41597
NCBI Gene ID	2915
Ensembl ID	ENSG00000163464
OMIM	146929
GeneCards	CXCR1
Human Protein Atlas	CXCR1
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis, Epilepsy
Interactions	CXCR4, CCR2, CCR3, CX3CL1, CX3CR1, CXCL12
KG Connections	99 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CXCR1 — AlphaFold P41597 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CXCR1["CXCR1"]
    CXCR1 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    CXCR1 -->|"target for"| Inflammation["Inflammation"]
    CXCR1 -->|"target for"| Neuroinflammation["Neuroinflammation"]
    CXCR1 -->|"target for"| Aging["Aging"]
    CXCR1 -->|"target for"| Ms["Ms"]
    CXCR1 -->|"target for"| OVERVIEW["OVERVIEW"]
    CX3CR1["CX3CR1"] -->|"target for"| CXCR1
    OVERVIEW -->|"target for"| CXCR1
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"] -->|"target for"| CXCR1
    NEURODEGENERATION["NEURODEGENERATION"] -->|"target for"| CXCR1
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"target for"| CXCR1
    NEURON["NEURON"] -->|"regulates"| CXCR1
    AGING["AGING"] -->|"regulates"| CXCR1

Outgoing (68)

Target	Relation	Type	Str
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Epilepsy	associated_with	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Ischemia	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Neuroinflammation	regulates	disease	0.65
Aging	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
OVERVIEW	therapeutic_target	gene	0.60
CX3CL1	associated_with	gene	0.60
CX3CR1	therapeutic_target	gene	0.60
CX3CR1	regulates	gene	0.60
OVERVIEW	regulates	gene	0.60
epilepsy	associated_with	disease	0.60
CXCR4	interacts_with	gene	0.60
MMP9	associated_with	gene	0.60
TLR2	associated_with	gene	0.60
TYROBP	associated_with	gene	0.60
MMP9	targets	gene	0.60
PARKINSON	associated_with	gene	0.60
BRAIN INJURY	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
EPILEPSY	associated_with	gene	0.60
HUNTINGTON'S DISEASE	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
AGING	regulates	gene	0.60
Neuroinflammatory	regulates	pathway	0.60
ALZHEIMER	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
NEURON	regulates	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
Parkinson's disease	associated_with	disease	0.60
Alzheimer's disease	associated_with	disease	0.60
Huntington's disease	associated_with	disease	0.60
traumatic brain injury	associated_with	disease	0.60
multiple sclerosis	associated_with	disease	0.60
ALS	associated_with	disease	0.60

Incoming (31)

Source	Relation	Type	Str
CX3CR1	therapeutic_target	gene	0.60
CX3CL1	associated_with	gene	0.60
OVERVIEW	therapeutic_target	gene	0.60
OVERVIEW	regulates	gene	0.60
CX3CR1	regulates	gene	0.60
CCR2	interacts_with	gene	0.60
CCR3	interacts_with	gene	0.60
CX3CL1	interacts_with	gene	0.60
CX3CR1	interacts_with	gene	0.60
CXCL12	interacts_with	gene	0.60
CXCL8	interacts_with	gene	0.60
CCR1	associated_with	gene	0.60
PARKINSON'S DISEASE	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.60
NEURODEGENERATION	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
HUNTINGTON'S DISEASE	associated_with	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	gene	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60
BRAIN INJURY	associated_with	gene	0.60
NEURON	regulates	gene	0.60
NEURODEGENERATIVE DISEASES	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
EPILEPSY	associated_with	gene	0.60
AGING	regulates	gene	0.60
HUNTINGTON	associated_with	gene	0.60
PARKINSON	associated_with	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
AND	associated_with	gene	0.60
CCL2	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CXCR1

Understanding Entity Pages

Summary

Wiki Pages (12)

CXCR1 Gene

XCL1 — X-C Motif Chemokine Ligand 1

Chemokine Signaling Pathway in Neurodegeneration

CXCL1

cxcl8

Cellular Senescence Disease Comparison

CXCL2 Protein

Neuroinflammation in Corticobasal Degeneration

CXCL8 Protein

CXCL2 — C-X-C Motif Chemokine Ligand 2