gene 1,022 words KG: CCL5
Contents

CCL5 — C-C Motif Chemokine Ligand 5

🧬 Gene Info
Gene SymbolCCL5
AliasesRANTES, SIS1, SCYA5
Chromosome17q12
FunctionGαi-mediated inhibition of adenylate cyclase
Molecular Weight8 kDa
Amino Acids91 aa
PathwaysPI3K, MAPK pathway, PI3K pathway
UniProt IDP08246
NCBI Gene ID6352
Ensembl IDENSG00000161570
OMIM187011
GeneCardsCCL5
Human Protein AtlasCCL5
Gene NameC-C Motif Chemokine Ligand 5
Associated DiseasesALS, Aging, Alzheimer, Cancer, Cirrhosis
InteractionsVDAC1, TBK1, CCR5, CCL4, CCL3, AKT
KG Connections467 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (6)

APOE-Dependent Autophagy Restoration
Score: 0.61
Senescence-Activated NAD+ Depletion Rescue
Score: 0.60
SASP-Driven Aquaporin-4 Dysregulation
Score: 0.59
Selective HDAC3 Inhibition with Cognitive Enhancement
Score: 0.56
Glymphatic System-Enhanced Antibody Clearance Reversal
Score: 0.54

Related Analyses (5)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (13)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: associated_with
Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
ATM Gene
gene · KG edge: regulates

Knowledge Graph (12 edges)

CCL5 activates VDAC1
CCL5 activates TBK1
CCL5 activates CCR5
CCL5 activates CCL4
CCL5 activates CCL3
CCL5 activates AKT
CCL5 activates PI3K
CCL5 inhibits CCR5
CCL5 expressed_in TNF
CCL5 expressed_in NOD2