gene

CXCL8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CXCL8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

510Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CXCL8 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with Aging, Als, Atherosclerosis. Connected to 164 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CXCL8
Full Name	cxcl8
Chromosome	4q13.3
Protein Family	CXC chemokine family (ELR+)
Protein Type	Gene
Function	is a protein encoded by the CXCL8 gene.
Primary Expression	the central nervous system, influencing neurotransmitter release and synaptic plasticity[@biber2002]
Subcellular Localization	Secreted, extracellular
Molecular Weight	8 kDa
Amino Acids	99 aa
Exons	4
Pathways	NF-κB
UniProt ID	[P10145](https://www.uniprot.org/uniprot/P10145)
NCBI Gene ID	3576
GeneCards	CXCL8
Human Protein Atlas	CXCL8
Associated Diseases	ALS, Alzheimer, Depression, Fibrosis, Inflammation, Ms
Known Drugs/Compounds	rapamycin
Interactions	ICAM1, IL6, TLR4, MYD88, TNF, P38
KG Connections	510 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CXCL8["CXCL8"]
    CXCL8 -->|"expressed in"| Tumor["Tumor"]
    CXCL8 -->|"target for"| Stroke["Stroke"]
    CXCL8 -->|"target for"| Ms["Ms"]
    CXCL8 -->|"target for"| Cardiovascular["Cardiovascular"]
    CXCL8 -->|"target for"| Atherosclerosis["Atherosclerosis"]
    CXCL8 -->|"activates"| Fibrosis["Fibrosis"]
    CXCL8 -->|"activates"| Inflammation["Inflammation"]
    CXCL8 -->|"regulates"| Senescence["Senescence"]
    IL1B["IL1B"] -->|"regulates"| CXCL8
    TLR2["TLR2"] -->|"regulates"| CXCL8
    CXCL1["CXCL1"] -->|"regulates"| CXCL8
    JUN["JUN"] -->|"regulates"| CXCL8
    MMP9["MMP9"] -->|"regulates"| CXCL8
    TNF["TNF"] -->|"regulates"| CXCL8
    GENES["GENES"] -->|"regulates"| CXCL8
    CCL3["CCL3"] -->|"regulates"| CXCL8

Outgoing (319)

Target	Relation	Type	Str
Inflammation	activates	disease	1.00
Tumor	expressed_in	disease	0.85
Inflammation	regulates	disease	0.75
Cancer	activates	disease	0.75
CCL5	associated_with	gene	0.70
Angiogenesis	activates	pathway	0.70
Mapk	activates	pathway	0.70
CANCER	activates	gene	0.70
Ms	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
Stroke	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Cardiovascular	therapeutic_target	disease	0.65
Atherosclerosis	therapeutic_target	disease	0.65
Fibrosis	activates	disease	0.65
Ms	activates	disease	0.65
Senescence	regulates	disease	0.65
Ms	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Fibrosis	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Als	activates	disease	0.65
Als	contributes_to	disease	0.65
Neuroinflammation	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Tumor	therapeutic_target	disease	0.65
Breast Cancer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Neuroinflammation	regulates	disease	0.65
Aging	biomarker_for	disease	0.65
Neuropathy	biomarker_for	disease	0.65
Alzheimer	associated_with	disease	0.65
Rheumatoid Arthritis	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Multiple Sclerosis	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Depression	therapeutic_target	disease	0.65
ALS	interacts_with	disease	0.65
Carcinoma	activates	disease	0.65
Depression	causes	disease	0.65
Cardiovascular	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Senescence	activates	disease	0.65
Autism	inhibits	disease	0.65
Atherosclerosis	inhibits	disease	0.65
Als	inhibits	disease	0.65
TLR2	regulates	gene	0.60
MMP9	regulates	gene	0.60
IL1B	regulates	gene	0.60

Incoming (191)

Source	Relation	Type	Str
AΒ1-42	alters	compound	0.80
SNCA	alters	gene	0.80
INFLAMMATION	activates	gene	0.80
MACROPHAGES	interacts_with	cell_type	0.70
IL1B	regulates	gene	0.60
TLR2	regulates	gene	0.60
CXCL1	regulates	gene	0.60
JUN	regulates	gene	0.60
MMP9	regulates	gene	0.60
TNF	regulates	gene	0.60
CCL3	regulates	gene	0.60
TNF	expressed_in	gene	0.60
PI3K	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
PI3K	activates	gene	0.60
GATA2	activates	gene	0.60
IL6	associated_with	gene	0.60
ANG	associated_with	gene	0.60
VEGF	expressed_in	gene	0.60
BAX	activates	gene	0.60
STAT1	activates	gene	0.60
FAS	activates	gene	0.60
VEGFA	activates	gene	0.60
JAK1	activates	gene	0.60
NFL	regulates	gene	0.60
GFAP	regulates	gene	0.60
OPTINEURIN	associated_with	gene	0.60
CDKN1A	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
AKT	associated_with	gene	0.60
TNF	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
CXCL1	associated_with	gene	0.60
UBIQUITIN	associated_with	gene	0.60
LC3	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
GAL	associated_with	gene	0.60
PRKN	associated_with	gene	0.60
PARKIN	associated_with	gene	0.60
ICAM1	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
S100A9	contributes_to	gene	0.60
S100A8	contributes_to	gene	0.60
CXCL12	associated_with	gene	0.60
ADCY2	associated_with	gene	0.60
GRM2	associated_with	gene	0.60
NPY	associated_with	gene	0.60
SIRT1	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CXCL8

Understanding Entity Pages

Summary

Wiki Pages (21)

cxcl8

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

neuroinflammation

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

Microglial Senescence Pathway in Neurodegeneration

Cellular Senescence in Neurodegeneration

Oligodendrocyte and Myelin Dysfunction in Corticobasal Syndrome

cGAS-STING Signaling in Parkinson's Disease

Cellular Senescence in Neurodegeneration

msa-oligodendrocyte-pathology

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

Neuroinflammation in Alzheimer's Disease

Arcuate Nucleus POMC Neurons

Astrocyte Senescence Pathway in Neurodegeneration

Inflammaging in Neurodegeneration

CBS Microglial Neuroimmune Axis

Senolytic Therapies for Parkinson's Disease

peripheral-immune-infiltration

IL-1α Protein