Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCL5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CCL5 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with Als, Alzheimer, Asthma. Connected to 247 entities in the SciDEX knowledge graph.
| Gene Symbol | CCL5 |
| Aliases | RANTES, SIS1, SCYA5 |
| Chromosome | 17q12 |
| Function | Gαi-mediated inhibition of adenylate cyclase |
| Molecular Weight | 8 kDa |
| Amino Acids | 91 aa |
| Pathways | PI3K, MAPK pathway, PI3K pathway |
| UniProt ID | P08246 |
| NCBI Gene ID | 6352 |
| Ensembl ID | ENSG00000161570 |
| OMIM | 187011 |
| GeneCards | CCL5 |
| Human Protein Atlas | CCL5 |
| Gene Name | C-C Motif Chemokine Ligand 5 |
| Associated Diseases | ALS, Aging, Alzheimer, Cancer, Cirrhosis |
| Interactions | VDAC1, TBK1, CCR5, CCL4, CCL3, AKT |
| KG Connections | 467 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
CCL5["CCL5"]
CCL5 -->|"activates"| CCR5["CCR5"]
CCL5 -->|"activates"| microglia["microglia"]
CCL5 -->|"activates"| Cancer["Cancer"]
CCL5 -->|"activates"| Als["Als"]
CCL5 -->|"activates"| Tumor["Tumor"]
CCL5 -->|"activates"| Huntington["Huntington"]
CCL5 -->|"activates"| Tauopathy["Tauopathy"]
CCL5 -->|"activates"| Neurodegeneration["Neurodegeneration"]
CCL5 -->|"expressed in"| Ms["Ms"]
FIP200["FIP200"] -->|"inhibits"| CCL5
CXCL10["CXCL10"] -->|"activates"| CCL5
DSDNA["DSDNA"] -->|"activates"| CCL5
STING["STING"] -->|"activates"| CCL5
MTDNA["MTDNA"] -->|"activates"| CCL5
CGAS["CGAS"] -->|"activates"| CCL5
MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| CCL5
GENES["GENES"] -->|"activates"| CCL5
DNA["DNA"] -->|"activates"| CCL5
IRF3["IRF3"] -->|"activates"| CCL5| Target | Relation | Type | Str |
|---|---|---|---|
| CCR5 | activates | gene | 1.00 |
| Axonogenesis | mediates | process | 0.95 |
| Neuronal Function Restoration | mediates | process | 0.92 |
| Synaptogenesis | activates | process | 0.90 |
| AXONOGENESIS | essential_for | process | 0.90 |
| neuronal restoration | essential_for | process | 0.90 |
| Mtor | activates | pathway | 0.90 |
| SYNAPTOPHYSIN | upregulates | protein | 0.88 |
| PSD95 | upregulates | protein | 0.88 |
| CCR5 Degradation | inhibits | process | 0.85 |
| Neurodegeneration | activates | disease | 0.85 |
| Inflammation | activates | disease | 0.85 |
| Traumatic Brain Injury | protects_against | disease | 0.85 |
| CD8 | activates | gene | 0.80 |
| STING | activates | gene | 0.80 |
| microglia | activates | cell_type | 0.80 |
| Aging | biomarker_for | process | 0.80 |
| MICROGLIA | activates | gene | 0.80 |
| Cancer | activates | disease | 0.75 |
| Als | activates | disease | 0.75 |
| Huntington | activates | disease | 0.75 |
| Tauopathy | activates | disease | 0.75 |
| Neuroinflammation | activates | disease | 0.75 |
| AKT | activates | gene | 0.70 |
| MTOR | activates | gene | 0.70 |
| MTORC1 | activates | gene | 0.70 |
| AUTOPHAGY | activates | gene | 0.70 |
| Autophagy | activates | pathway | 0.70 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.70 |
| TAUOPATHY | activates | gene | 0.70 |
| neurons | expressed_in | cell_type | 0.70 |
| IFN | activates | gene | 0.70 |
| Tumor | activates | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| Neuroinflammation | regulates | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Autism | regulates | disease | 0.65 |
| Inflammation | inhibits | disease | 0.65 |
| Fibrosis | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Neuropathy | associated_with | disease | 0.65 |
| Neurodegeneration | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Traumatic Brain Injury | treats | disease | 0.65 |
| Neurodegeneration | treats | disease | 0.65 |
| Autoimmune | activates | disease | 0.65 |
| Asthma | interacts_with | disease | 0.65 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Astrocytes | product_of | cell_type | 0.90 |
| Senolytic Drugs | downregulates | drug | 0.88 |
| FIP200 | inhibits | protein | 0.80 |
| AΒ1-42 | alters | compound | 0.80 |
| SNCA | alters | gene | 0.80 |
| NEURODEGENERATION | activates | gene | 0.80 |
| PI3K | activates | gene | 0.70 |
| CXCL8 | associated_with | gene | 0.70 |
| HDAC3 | inhibits | gene | 0.70 |
| DNA | activates | gene | 0.70 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.70 |
| HUNTINGTON | activates | gene | 0.70 |
| NEUROINFLAMMATION | activates | gene | 0.70 |
| CCL2 | regulates | gene | 0.70 |
| MTOR | inhibits | gene | 0.65 |
| TBK1 | causes | gene | 0.65 |
| CXCL10 | activates | gene | 0.60 |
| STING | activates | gene | 0.60 |
| CGAS | activates | gene | 0.60 |
| IRF3 | activates | gene | 0.60 |
| CCL4 | activates | gene | 0.60 |
| CCL3 | activates | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| CCR5 | inhibits | gene | 0.60 |
| CD4 | interacts_with | gene | 0.60 |
| MAPK3 | interacts_with | gene | 0.60 |
| ZAP70 | interacts_with | gene | 0.60 |
| TP53 | interacts_with | gene | 0.60 |
| CD19 | interacts_with | gene | 0.60 |
| EEF2 | interacts_with | gene | 0.60 |
| CXCL8 | activates | gene | 0.60 |
| CCL4 | associated_with | gene | 0.60 |
| IL7 | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| IL18 | associated_with | gene | 0.60 |
| IL7R | associated_with | gene | 0.60 |
| BCL2 | associated_with | gene | 0.60 |
| PSMB9 | associated_with | gene | 0.60 |
| GNB4 | regulates | gene | 0.60 |
| IL1B | associated_with | gene | 0.60 |
| FIP200 | activates | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| SYNAPTOPHYSIN | inhibits | gene | 0.60 |
| GATA2 | activates | gene | 0.60 |
| IL6 | associated_with | gene | 0.60 |
| ANG | associated_with | gene | 0.60 |
| CXCL1 | associated_with | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| CCR8 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||