gene

CCL5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CCL5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

467Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

CCL5 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, interacts with. Associated with Als, Alzheimer, Asthma. Connected to 247 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCCL5
AliasesRANTES, SIS1, SCYA5
Chromosome17q12
FunctionGαi-mediated inhibition of adenylate cyclase
Molecular Weight8 kDa
Amino Acids91 aa
PathwaysPI3K, MAPK pathway, PI3K pathway
UniProt IDP08246
NCBI Gene ID6352
Ensembl IDENSG00000161570
OMIM187011
GeneCardsCCL5
Human Protein AtlasCCL5
Gene NameC-C Motif Chemokine Ligand 5
Associated DiseasesALS, Aging, Alzheimer, Cancer, Cirrhosis
InteractionsVDAC1, TBK1, CCR5, CCL4, CCL3, AKT
KG Connections467 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: CCL5 — AlphaFold P08246 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CCL5 — C-C Motif Chemokine Ligand 5

gene · 1022 words

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

mechanism · 7227 words

neuroinflammation

mechanism · 5462 words

Microglial Senescence Pathway in Neurodegeneration

mechanism · 3902 words

Cellular Senescence in Neurodegeneration

mechanism · 3734 words

Neuroinflammation in Amyotrophic Lateral Sclerosis

mechanism · 3509 words

Pathway Diagram

graph TD
    CCL5["CCL5"]
    CCL5 -->|"activates"| CCR5["CCR5"]
    CCL5 -->|"activates"| microglia["microglia"]
    CCL5 -->|"activates"| Cancer["Cancer"]
    CCL5 -->|"activates"| Als["Als"]
    CCL5 -->|"activates"| Tumor["Tumor"]
    CCL5 -->|"activates"| Huntington["Huntington"]
    CCL5 -->|"activates"| Tauopathy["Tauopathy"]
    CCL5 -->|"activates"| Neurodegeneration["Neurodegeneration"]
    CCL5 -->|"expressed in"| Ms["Ms"]
    FIP200["FIP200"] -->|"inhibits"| CCL5
    CXCL10["CXCL10"] -->|"activates"| CCL5
    DSDNA["DSDNA"] -->|"activates"| CCL5
    STING["STING"] -->|"activates"| CCL5
    MTDNA["MTDNA"] -->|"activates"| CCL5
    CGAS["CGAS"] -->|"activates"| CCL5
    MITOCHONDRIAL_DNA["MITOCHONDRIAL DNA"] -->|"activates"| CCL5
    GENES["GENES"] -->|"activates"| CCL5
    DNA["DNA"] -->|"activates"| CCL5
    IRF3["IRF3"] -->|"activates"| CCL5

Outgoing (300)

TargetRelationTypeStr
CCR5activatesgene1.00
Axonogenesismediatesprocess0.95
Neuronal Function Restorationmediatesprocess0.92
Synaptogenesisactivatesprocess0.90
AXONOGENESISessential_forprocess0.90

Incoming (167)

SourceRelationTypeStr
Astrocytesproduct_ofcell_type0.90
Senolytic Drugsdownregulatesdrug0.88
FIP200inhibitsprotein0.80
AΒ1-42alterscompound0.80
SNCAaltersgene0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found