gene

CX3CL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CX3CL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

452Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Page for CX3CL1 — Fractalkine (C-X3-C Motif Chemokine Ligand 1)

View on Wiki →

🧬 Gene Info

Gene Symbol	CX3CL1
Full Name	Fractalkine (C-X3-C Motif Chemokine Ligand 1)
Aliases	C-X3-C Motif Chemokine Ligand 1
Chromosome	16q13
Primary Expression	Neurons (cortex, hippocampus), Endothelial cells, Dendritic cells
Amino Acids	373 aa
Pathways	Neuroinflammatory
UniProt ID	P78423
NCBI Gene ID	6376
Ensembl ID	ENSG00000006210
OMIM	601880
GeneCards	CX3CL1
Human Protein Atlas	CX3CL1
Associated Diseases	ALS, Alzheimer, Alzheimer'S Disease, Amyotrophic Lateral Sclerosis
Interactions	VIM, BDNF, FGF23, FNDC5, CX3CR1, SIRT1
KG Connections	449 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CX3CL1 — AlphaFold P78423 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CX3CL1["CX3CL1"]
    CX3CL1 -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
    CX3CL1 -->|"regulates"| Inflammation["Inflammation"]
    CX3CL1 -->|"regulates"| Neuroinflammation["Neuroinflammation"]
    CX3CL1 -->|"target for"| Aging["Aging"]
    CX3CL1 -->|"interacts"| Ms["Ms"]
    CX3CL1 -.biomarker for.-> Senescence["Senescence"]
    CX3CL1 -.biomarker for.-> Als["Als"]
    CX3CL1 -.biomarker for.-> Longevity["Longevity"]
    CX3CR1["CX3CR1"] -->|"target for"| CX3CL1
    FGF21["FGF21"] -->|"activates"| CX3CL1
    APP["APP"] -.biomarker for.-> CX3CL1
    FNDC5["FNDC5"] -->|"activates"| CX3CL1
    S100B["S100B"] -.biomarker for.-> CX3CL1
    PLAU["PLAU"] -->|"activates"| CX3CL1
    CXCL10["CXCL10"] -->|"activates"| CX3CL1
    C1Q["C1Q"] -.biomarker for.-> CX3CL1
    OVERVIEW["OVERVIEW"] -->|"expressed in"| CX3CL1
    FGF23["FGF23"] -->|"activates"| CX3CL1

Outgoing (308)

Target	Relation	Type	Str
Fractalkine	associated_with	protein	0.95
Frailty	biomarker_for	phenotype	0.95
Neurons	interacts_with	cell_type	0.95
Neuroinflammation	modulates	process	0.95
Neuron-Glial Signaling	mediates	pathway	0.90
Neurons	expressed_in	cell_type	0.90
CX3CR1/AMPK/PPARG Pathway	activates	pathway	0.90
Neuron-Glial Signaling	involved_in	pathway	0.90
Microglial activation	modulates	process	0.90
Microglia	interacts_with	cell_type	0.90
NEURON	expressed_in	cell_type	0.90
Blood-Brain Barrier	regulates	brain_region	0.90
Hematoma Resolution	associated_with	process	0.85
Germinal Matrix Hemorrhage	protects_against	disease	0.85
Neurodegeneration	targets	disease	0.85
Neurodegenerative Diseases	therapeutic_target	disease	0.85
GNB5	regulates	protein	0.80
neurodegenerative disease	implicated_in	disease	0.80
CX3CR1	engages	protein	0.80
microglia	expressed_in	cell_type	0.80
neurodegenerative diseases	targets	disease	0.80
Inflammation	activates	disease	0.75
neurons	expressed_in	cell_type	0.70
CX3CR1	stabilizes	gene	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Epilepsy	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Ischemia	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Traumatic Brain Injury	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Inflammation	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Als	biomarker_for	disease	0.65
Aging	biomarker_for	disease	0.65
Longevity	biomarker_for	disease	0.65
Fibrosis	biomarker_for	disease	0.65
Fibrosis	activates	disease	0.65
Als	activates	disease	0.65
Ms	activates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	activates	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	activates	disease	0.65

Incoming (144)

Source	Relation	Type	Str
Repetitive Transcranial Magnetic Stimulation	upregulates	drug	0.92
GABAergic Neuron	produces	cell_type	0.90
h-494861d2	targets_gene	hypothesis	0.90
miR-125b-5p	downregulates	biomarker	0.85
miR-16-5p	downregulates	biomarker	0.85
CCL2	regulates	gene	0.70
h-494861d2	targets	hypothesis	0.70
ASTROCYTE	reduces	cell_type	0.65
CX3CR1	therapeutic_target	gene	0.60
FGF21	activates	gene	0.60
APP	biomarker_for	gene	0.60
FNDC5	activates	gene	0.60
S100B	biomarker_for	gene	0.60
PLAU	activates	gene	0.60
CXCL10	activates	gene	0.60
C1Q	biomarker_for	gene	0.60
CXCR1	associated_with	gene	0.60
OVERVIEW	expressed_in	gene	0.60
FGF23	activates	gene	0.60
GPNMB	biomarker_for	gene	0.60
BDNF	activates	gene	0.60
RAGE	activates	gene	0.60
LGALS3	activates	gene	0.60
BLM	activates	gene	0.60
CCL20	regulates	gene	0.60
STAT3	regulates	gene	0.60
CTSB	activates	gene	0.60
CTSL	activates	gene	0.60
CTSS	activates	gene	0.60
JAK2	activates	gene	0.60
STAT3	activates	gene	0.60
APP	activates	gene	0.60
CXCR5	activates	gene	0.60
GFAP	activates	gene	0.60
YY1	inhibits	gene	0.60
CX3CR1	associated_with	gene	0.60
CX3CR1	activates	gene	0.60
CTSS	regulates	gene	0.60
CX3CR1	interacts_with	gene	0.60
VIMENTIN	activates	gene	0.60
VIM	activates	gene	0.60
HMGB1	biomarker_for	gene	0.60
PROGRANULIN	activates	gene	0.60
CX3CR1	expressed_in	gene	0.60
TGM2	biomarker_for	gene	0.60
CXCL10	expressed_in	gene	0.60
TAU	inhibits	gene	0.60
STAT1	activates	gene	0.60
TMEM119	activates	gene	0.60
IBA1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Neuroinflammation and microglial priming in early Alzheimer's Disease

neurodegeneration | 2026-04-04 | 14 hypotheses Top: 0.508

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CX3CL1

Understanding Entity Pages

Summary

Wiki Pages (21)

Fractalkine (CX3CL1) - Neuroinflammation Biomarker

Novel Therapy Index

neuroinflammation

Microglial Cells — Cell Type Hierarchy

Neuroinflammation Across AD, PD, ALS, FTD, and HD

Neuroinflammation in Amyotrophic Lateral Sclerosis

JAK-STAT Signaling Pathway in Neurodegeneration

microglial-synaptic-pruning-dysregulation

Neuroinflammation in Alzheimer's Disease

Neuroinflammation Pathway

Neuroinflammation in Alzheimer and Parkinson Disease

Neuroinflammation and Microglia Pathway

Synaptic Loss and Dysfunction Pathway

CBS Microglial Neuroimmune Axis

neuroinflammation-ad-pd-als

Microglia and neuroinflammation in Alzheimer's Disease

peripheral-immune-infiltration

Microglia-Neuron Metabolic Cross-Talk in Neurodegeneration

Efferocytosis in Neurodegeneration

Brainstem Laterodorsal Tegmental Nucleus