protein

CD274

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CD274: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

33Connections

0Hypotheses

0Analyses

17Outgoing

16Incoming

No summary available yet. View on Wiki →

🔬 Protein Info

Gene Symbol	CD274
Pathways	Autophagy-Lysosomal Pathway, autophagy pathway
GeneCards	CD274
Human Protein Atlas	CD274
Associated Diseases	CMTM6, BAICALEIN
Known Drugs/Compounds	Baicalein, Atezolizumab, Durvalumab, Avelumab, BAICALEIN
Interactions	LC3, MAP1LC3B
KG Connections	33 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

PD-1/PD-L1 Immune Checkpoint Signaling in Neurodegeneration

mechanism · 3120 words

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Pathway Diagram

graph TD
    CD274["CD274"] -->|"interacts"| LC3["LC3"]
    style LC3 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CD274["CD274"] -->|"binds"| PDCD1["PDCD1"]
    style PDCD1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CD274["CD274"] -.->|"inhibits"| T_Cell_Activity["T Cell Activity"]
    style T_Cell_Activity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    CD274["CD274"] -->|"interacts"| MAP1LC3B["MAP1LC3B"]
    style MAP1LC3B fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CD274["CD274"] -->|"involved in"| Autophagic_Lysosomal_Degradati["Autophagic-Lysosomal Degradation"]
    style Autophagic_Lysosomal_Degradati fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    CD274["CD274"] -->|"involved in"| Immune_Checkpoint["Immune Checkpoint"]
    style Immune_Checkpoint fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    CD274["CD274"] -.->|"inhibits"| T_cell_mediated_immunity["T-cell-mediated immunity"]
    style T_cell_mediated_immunity fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Baicalein["Baicalein"] -->|"targets"| CD274["CD274"]
    style Baicalein fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    autophagy_lysosomal_pathway["autophagy-lysosomal pathway"] -->|"promotes"| CD274["CD274"]
    style autophagy_lysosomal_pathway fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Atezolizumab["Atezolizumab"] -->|"targets"| CD274["CD274"]
    style Atezolizumab fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Durvalumab["Durvalumab"] -->|"targets"| CD274["CD274"]
    style Durvalumab fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Avelumab["Avelumab"] -->|"targets"| CD274["CD274"]
    style Avelumab fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    style CD274 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (17)

Target	Relation	Type	Str
LC3	interacts_with	protein	0.95
PDCD1	binds	gene	0.95
T Cell Activity	inhibits	process	0.95
MAP1LC3B	interacts_with	protein	0.90
Autophagic-Lysosomal Degradation	involved_in	process	0.90
T-cell-mediated immunity	inhibits	process	0.87
tumor development	promotes	phenotype	0.85
Autophagy-Lysosomal Pathway	involved_in	pathway	0.85
T-Cell-Mediated Antitumor Immunity	suppresses	process	0.85
Cancer	treats	disease	0.85
Antitumor Immunity	modulates	process	0.85
Cancer Cell Proliferation	involved_in	process	0.85
Systemic Immune Suppression	mediates	process	0.85
T cell exhaustion	promotes	phenotype	0.85
Cancer Progression	promotes	process	0.80
autophagy pathway	participates_in	pathway	0.60
CMTM6	associated_with	gene	0.60

Incoming (16)

Source	Relation	Type	Str
Baicalein	targets	compound	0.95
Baicalein	degrades	compound	0.95
autophagy-lysosomal pathway	promotes	pathway	0.92
Atezolizumab	targets	drug	0.90
Durvalumab	targets	drug	0.90
Avelumab	targets	drug	0.90
IFNG	upregulates	gene	0.90
LC3	upstream_of	protein	0.88
baicalein	binds_to	drug	0.85
Autophagy-Lysosomal Pathway	degrades	pathway	0.85
MAP1LC3B	binds	protein	0.85
SPOP	degrades	protein	0.85
BAICALEIN	activates	drug	0.65
AUTOPHAGY	regulates	phenotype	0.65
ATXN3	co_expressed_with	gene	0.60
BAICALEIN	associated_with	drug	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found