Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AUTOPHAGY-LYSOSOMAL PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AUTOPHAGY-LYSOSOMAL PATHWAY |
Knowledge base pages for this entity
graph TD
AUTOPHAGY_LYSOSOMAL_PATHWAY["AUTOPHAGY-LYSOSOMAL PATHWAY"]
AUTOPHAGY_LYSOSOMAL_PATHWAY -->|"promotes"| CD274["CD274"]
AUTOPHAGY_LYSOSOMAL_PATHWAY -->|"involved_in"| Neuronal_Health["Neuronal Health"]
AUTOPHAGY_LYSOSOMAL_PATHWAY -->|"mediates"| CD274_Degradation["CD274 Degradation"]
AUTOPHAGY_LYSOSOMAL_PATHWAY -->|"involved_in"| Parkinson_S_Disease["Parkinson'S Disease"]
AUTOPHAGY_LYSOSOMAL_PATHWAY -->|"downstream_of"| NLRP3_inflammasome["NLRP3 inflammasome"]
AUTOPHAGY_LYSOSOMAL_PATHWAY -->|"involved_in"| Parkinson_s_Disease["Parkinson's Disease"]
AUTOPHAGY_LYSOSOMAL_PATHWAY -.protects against.-> protein_aggregation["protein aggregation"]
SNCA["SNCA"] -->|"interacts"| AUTOPHAGY_LYSOSOMAL_PATHWAY
TFEB["TFEB"] -->|"mediates"| AUTOPHAGY_LYSOSOMAL_PATHWAY
GBA["GBA"] -->|"regulates"| AUTOPHAGY_LYSOSOMAL_PATHWAY
CD274 -->|"involved_in"| AUTOPHAGY_LYSOSOMAL_PATHWAY
SQSTM1["SQSTM1"] -->|"regulates"| AUTOPHAGY_LYSOSOMAL_PATHWAY| Target | Relation | Type | Str |
|---|---|---|---|
| SNCA | interacts_with | protein | 0.92 |
| CD274 | promotes | protein | 0.92 |
| Neuronal Health | involved_in | phenotype | 0.90 |
| CD274 Degradation | mediates | process | 0.90 |
| Parkinson'S Disease | involved_in | disease | 0.90 |
| Parkinson's Disease | contributes_to | disease | 0.90 |
| NLRP3 inflammasome | downstream_of | protein | 0.88 |
| Parkinson's Disease | associated_with | disease | 0.88 |
| Parkinson's Disease | involved_in | disease | 0.85 |
| CD274 | degrades | protein | 0.85 |
| protein aggregation | protects_against | process | 0.70 |
| Misfolded protein aggregation | regulates | process | 0.70 |
| protein aggregation | protects_against | process | 0.70 |
| α-synuclein aggregation | regulates | process | 0.70 |
| protein aggregates | inhibits | process | 0.70 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| Parkinson's disease | associated_with | disease | 0.70 |
| Huntington's disease | associated_with | disease | 0.70 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| Parkinson's disease | associated_with | disease | 0.70 |
| Huntington's disease | associated_with | disease | 0.70 |
| alpha-synuclein | activates | protein | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ISG15 | regulates | gene | 0.95 |
| SNCA | interacts_with | protein | 0.90 |
| TFEB | mediates | gene | 0.90 |
| LRRK2 | regulates | gene | 0.90 |
| GBA1 | involved_in | gene | 0.90 |
| Alpha-Synuclein Aggregation | involved_in | process | 0.90 |
| SNCA | regulates | protein | 0.90 |
| AMPK | activates | protein | 0.90 |
| TFEB | regulates | gene | 0.89 |
| GBA | regulates | gene | 0.88 |
| CD274 | involved_in | protein | 0.85 |
| LAMP2 | involved_in | protein | 0.80 |
| TFEB | activates | protein | 0.70 |
| SQSTM1 | regulates | protein | 0.70 |
| TFEB | regulates | protein | 0.70 |
| BECN1 | regulates | gene | 0.70 |
| AMPK/mTORC1 | activates | pathway | 0.70 |
| TAL1 | regulates | protein | 0.70 |
| AMPK/mTORC1 pathway | activates | pathway | 0.70 |
| ATM | regulates | gene | 0.70 |
| USP14 | regulates | protein | 0.70 |
| PSEN1 | involved_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||