Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CD3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| IL30 | associated_with | gene | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.586
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Microglia at the Forefront: New Insights From the Glial Club South Cone Meeting [PMID:41668347] | Giambartolomei GH, Iribarren P, Pasquini | J Neurochem | 2026 | 0 |
| Corrigendum to “CD300f enables microglial damage sensing, efferocytosis, and apo [PMID:41734445] | Negro-Demontel Luciana; Evans Frances; C | Brain, Behavior, and Immunity | 2026 | 0 |
| IgE-dependent anaphylaxis is regulated by sphingolipid binding to activating and [PMID:41790557] | Izawa K, Kaitani A, Enomoto Y, Ando T, Y | Cell Rep | 2026 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning CD3 in their description or question text
Score: 0.380 · als-and-alzheimers · 2026-04-27
Under neurodegenerative stress, astrocytes upregulate CD38, which triggers Erk MAPK signaling to promote tunneling nanot
Score: 0.380 · metabolomics · 2026-04-27
This hypothesis proposes that CD38, the primary NAD+-consuming enzyme, represents a more effective therapeutic target th
Score: 0.380 · metabolomics · 2026-04-26
This hypothesis proposes that targeting CD38, the primary NAD+-consuming enzyme, represents a more direct therapeutic ap
Score: 0.105 · neurodegeneration · 2026-04-18
## Mechanistic Overview CD300f Immunoglobulin Receptor as Neuroinflammatory Brake starts from the claim that modulating
Score: 0.000 · unknown disease · 2026-04-28
Pharmacological activation of CD38 in astrocytes could enhance mitochondrial release and transfer to neurons, providing
Score: 0.000 · unknown disease · 2026-04-28
CD33 is a microglial-specific sialic acid-binding receptor that regulates immune activation. Modulating CD33-mediated si