protein 734 words KG: CD33 2026-03-21
kind:proteinsection:proteinsstate:published
Contents

CD33 (Siglec-3)

🔬 Protein Info
Gene SymbolCD33
AliasesSiglec-3
Chromosome19q13.41
FunctionSialic acid binding: Recognizes α2,6-linked sialic acids on glycoproteins
Molecular Weight67 kDa
Amino Acids354 aa
Exons7
PathwaysApoptosis, Autophagy, Blood-Brain Barrier, Dysbiosis, Epigenetic
UniProt ID[P20138](https://www.uniprot.org/uniprot/P20138)
GeneCardsCD33
Human Protein AtlasCD33
Associated DiseasesALS, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, Aging
Known Drugs/CompoundsStem Cell Therapy
InteractionsOVERVIEW, PSEN1, BCL2, APP, DAP12, APOE
KG Connections708 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.51
APOE Isoform Conversion Therapy
Score: 0.44
Blocking AGE-RAGE Signaling in Enteric Glia to Prevent Neuro
Score: 0.42
SASP-Mediated Complement Cascade Amplification
Score: 0.70
TREM2-Dependent Microglial Senescence Transition
Score: 0.69

Related Analyses (11)

Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived

Related Experiments (2)

Why Does Amyloid Removal Only Slow Decline 27%? — Mechanisti
clinical · proposed · Score: 0.40
DLB Cognitive Fluctuation Mechanism Experiment
clinical · proposed · Score: 0.40

See Also (9)

Aging vs Neurodegeneration: Mechanistic Comparison Matr
mechanism · KG edge: associated_with
Packard Center for ALS Research
institution · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates
adam17
gene · KG edge: associated_with
ADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: co_discussed

Knowledge Graph (12 edges)

CD33 mediates TREM2
CD33 mediates TYROBP
CD33 associated_with CR1
CD33 associated_with CTSB
CD33 associated_with CTSH
CD33 associated_with EED
CD33 associated_with GRN
CD33 associated_with INPP5D
CD33 associated_with LILRB2
CD33 associated_with PICALM