protein 590 words KG: ABCD3 2026-03-22
kind:proteinsection:proteinsstate:published
Contents

ABCD3 Protein

🔬 Protein Info
Gene SymbolABCD3
Chromosome1p22.1
Protein FamilyABC transporter subfamily D
Protein TypeTransporter
FunctionABCD3 functions as a peroxisomal membrane transporter
Primary Expressionmultiple tissues, with highest levels in liver, kidney, and brain
Subcellular LocalizationPeroxisomal membrane
Molecular Weight79.7 kDa
PathwaysTgf-Beta, Wnt
UniProt ID[O75323](https://www.uniprot.org/uniprot/O75323)
GeneCardsABCD3
Human Protein AtlasABCD3
Associated DiseasesAD, ALI, ALS, Alzheimer, Cancer
InteractionsFIP200, RTN3, SESN2, LMNA, MAP1LC3B, OPTN
KG Connections474 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (10)

Phase-Separated Organelle Targeting
Score: 0.52
Stress Granule Phase Separation Modulators
Score: 0.49
RNA Granule Nucleation Site Modulation
Score: 0.48
Mitochondrial Transfer Pathway Enhancement
Score: 0.44
Miro1-Mediated Mitochondrial Trafficking Enhancement Therapy
Score: 0.43

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (9)

Actin Cytoskeleton Dynamics in Neurodegeneration
mechanism · KG edge: co_discussed
Packard Center for ALS Research
institution · KG edge: activates
Accelerating Medicines Partnership for Alzheimer's Dise
institution · KG edge: implicated_in
Alzheimer Indonesia
institution · KG edge: activates
ABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

ABCD3 activates AMBRA1
ABCD3 activates ATM
ABCD3 activates BCL2
ABCD3 activates BCL2L11
ABCD3 activates BCL2L13
ABCD3 activates BECN1
ABCD3 activates BNIP3
ABCD3 activates BNIP3L
ABCD3 activates CALCOCO2
ABCD3 activates CANX