Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about il30: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | IL30 |
| Full Name | Interleukin 30 (IL-27 p28 subunit) |
| Chromosome | 1p13.1 |
| Function | encodes a secreted glycoprotein that plays critical roles in immune regulation, particularly in the context of neuroinflammation, autoimmunity, and potentially neurodegenerative diseases. |
| Primary Expression | Immune cells, CNS microglia, astrocytes |
| Molecular Weight | 27 kDa |
| Amino Acids | 241 aa |
| Exons | 5 |
| UniProt ID | Q8TD97 |
| NCBI Gene ID | 359710 |
| GeneCards | IL30 |
| Human Protein Atlas | IL30 |
| Associated Diseases | Prostate Cancer, neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
IL30["IL30"]
IL30 -->|"inhibits"| Liver_Injury["Liver Injury"]
IL30 -->|"expressed in"| Hepatocytes["Hepatocytes"]
IL30 -->|"inhibits"| IGF1["IGF1"]
IL30 -->|"inhibits"| CXCL5["CXCL5"]
IL30 -->|"upregulates"| SOCS3["SOCS3"]
IL30 -->|"inhibits"| Cancer["Cancer"]
IL30 -->|"implicated in"| neurodegeneration["neurodegeneration"]
EGF["EGF"] -->|"expressed in"| IL30
HGF["HGF"] -->|"expressed in"| IL30
CCL2["CCL2"] -->|"expressed in"| IL30
VEGFA["VEGFA"] -->|"expressed in"| IL30
CDH1["CDH1"] -->|"expressed in"| IL30
ANG["ANG"] -->|"expressed in"| IL30
PLG["PLG"] -->|"expressed in"| IL30
PTEN["PTEN"] -->|"expressed in"| IL30| Target | Relation | Type | Str |
|---|---|---|---|
| Liver Injury | inhibits | disease | 0.90 |
| Hepatocytes | expressed_in | cell_type | 0.90 |
| IGF1 | inhibits | gene | 0.80 |
| CXCL5 | inhibits | gene | 0.80 |
| SOCS3 | upregulates | gene | 0.80 |
| Prostate Cancer | associated_with | disease | 0.80 |
| Cancer | inhibits | disease | 0.65 |
| benchmark_ot_ad_answer_key:IL30 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CD3 | associated_with | receptor | 0.80 |
| IL12 | associated_with | gene | 0.80 |
| IFN-Γ | associated_with | gene | 0.80 |
| EGF | expressed_in | gene | 0.60 |
| VEGFA | expressed_in | gene | 0.60 |
| ANG | expressed_in | gene | 0.60 |
| PLG | expressed_in | gene | 0.60 |
| PTEN | expressed_in | gene | 0.60 |
| EFNB2 | expressed_in | gene | 0.60 |
| NFKB1 | inhibits | gene | 0.60 |
| HGF | expressed_in | gene | 0.60 |
| CCL2 | expressed_in | gene | 0.60 |
| CDH1 | expressed_in | gene | 0.60 |
| benchmark_ot_ad_answer_key:IL30 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||