Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDC25B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CDC25B is a gene implicated in neurodegeneration research. Key relationships include: biomarker for, associated with, regulates. Associated with Als, Cancer, Ms. Connected to 19 entities in the SciDEX knowledge graph.
| Gene Symbol | CDC25B |
| Chromosome | 20p13 |
| Protein Type | Phosphatase |
| Function | is a dual-specificity protein phosphatase that plays a critical role in regulating cell cycle progression by removing inhibitory phosphates from cyclin-dependent kinases (CDKs)[@cdc2021]. |
| Primary Expression | various cancers: |
| Subcellular Localization | **: Nuclear import/export controls |
| Molecular Weight | 72 kDa |
| Amino Acids | 647 aa |
| GeneCards | CDC25B |
| Human Protein Atlas | CDC25B |
| CDK | Cyclin Partner |
| CDK1 | Cyclin A |
| CDK2 | Cyclin A |
| Associated Diseases | neurodegeneration |
| Known Drugs/Compounds | farrerol, menadione |
| Interactions | Cdc2, PKCδ |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CDC25B["<b>CDC25B</b>"]
Cdc2["Cdc2"]
CDC25B -->|"activates"| Cdc2
Als{"Als"}
CDC25B -->|"biomarker for"| Als
Ms{"Ms"}
CDC25B -->|"biomarker for"| Ms
Cancer{"Cancer"}
CDC25B -->|"biomarker for"| Cancer
Tumor{"Tumor"}
CDC25B -->|"biomarker for"| Tumor
CD8["CD8"]
CDC25B -->|"biomarker for"| CD8
CANCER["CANCER"]
CDC25B -->|"biomarker for"| CANCER
GBM["GBM"]
CDC25B -->|"biomarker for"| GBM
CDK4["CDK4"]
CDC25B -->|"associated with"| CDK4
UHRF1["UHRF1"]
CDC25B -->|"associated with"| UHRF1
neurodegeneration["neurodegeneration"]
CDC25B -->|"implicated in"| neurodegeneration
indigo_naturalis["indigo naturalis"]
indigo_naturalis -->|"downregulates"| CDC25B
PKC_["PKCdelta"]
PKC_ -->|"phosphorylates"| CDC25B
farrerol["farrerol"]
farrerol -->|"binds"| CDC25B
PI3K_mTOR_inhibitors["PI3K-mTOR inhibitors"]
PI3K_mTOR_inhibitors -->|"regulates"| CDC25B
menadione["menadione"]
menadione -->|"inhibits"| CDC25B
CD4["CD4"]
CD4 -->|"biomarker for"| CDC25B
MMP7["MMP7"]
MMP7 -->|"associated with"| CDC25B
MMP1["MMP1"]
MMP1 -->|"associated with"| CDC25B
style CDC25B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | provides_data_for | dataset | 1.00 |
| Cdc2 | activates | protein | 0.80 |
| Als | biomarker_for | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| Cancer | biomarker_for | disease | 0.65 |
| Tumor | biomarker_for | disease | 0.65 |
| CD8 | biomarker_for | gene | 0.60 |
| GBM | biomarker_for | gene | 0.60 |
| CDK4 | associated_with | gene | 0.60 |
| UHRF1 | associated_with | gene | 0.60 |
| CANCER | biomarker_for | gene | 0.60 |
| benchmark_ot_ad_answer_key:CDC25B | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-83b31ef18d49 | data_in | dataset | 1.00 |
| indigo naturalis | downregulates | drug | 0.90 |
| PKCδ | phosphorylates | protein | 0.80 |
| farrerol | binds | drug | 0.80 |
| PI3K-mTOR inhibitors | regulates | drug | 0.80 |
| menadione | inhibits | drug | 0.70 |
| CD4 | biomarker_for | gene | 0.60 |
| MMP7 | associated_with | gene | 0.60 |
| MMP1 | associated_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:CDC25B | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||